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The phosphatase mechanism of bifunctional kinase/phosphatase AceK.
Chem Commun (Camb). 2014 Nov 25; 50(91):14117-20.CC

Abstract

We have revealed that bifunctional AceK kinase/phosphatase utilizes a stepwise addition-elimination mechanism in its dephosphorylation reaction. This work explains how AceK enables opposite kinase and phosphatase activities with Asp477 and a single Mg(2+) ion.

Authors+Show Affiliations

College of Chemistry, Beijing Normal University, Beijing, 100875, China. jimin_z@bnu.edu.cn hongwei.tan@bnu.edu.cn.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25272278

Citation

Wang, Shu, et al. "The Phosphatase Mechanism of Bifunctional Kinase/phosphatase AceK." Chemical Communications (Cambridge, England), vol. 50, no. 91, 2014, pp. 14117-20.
Wang S, Shen Q, Chen G, et al. The phosphatase mechanism of bifunctional kinase/phosphatase AceK. Chem Commun (Camb). 2014;50(91):14117-20.
Wang, S., Shen, Q., Chen, G., Zheng, J., Tan, H., & Jia, Z. (2014). The phosphatase mechanism of bifunctional kinase/phosphatase AceK. Chemical Communications (Cambridge, England), 50(91), 14117-20. https://doi.org/10.1039/c4cc05375c
Wang S, et al. The Phosphatase Mechanism of Bifunctional Kinase/phosphatase AceK. Chem Commun (Camb). 2014 Nov 25;50(91):14117-20. PubMed PMID: 25272278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The phosphatase mechanism of bifunctional kinase/phosphatase AceK. AU - Wang,Shu, AU - Shen,Qingya, AU - Chen,Guangju, AU - Zheng,Jimin, AU - Tan,Hongwei, AU - Jia,Zongchao, PY - 2014/10/2/entrez PY - 2014/10/2/pubmed PY - 2015/6/24/medline SP - 14117 EP - 20 JF - Chemical communications (Cambridge, England) JO - Chem Commun (Camb) VL - 50 IS - 91 N2 - We have revealed that bifunctional AceK kinase/phosphatase utilizes a stepwise addition-elimination mechanism in its dephosphorylation reaction. This work explains how AceK enables opposite kinase and phosphatase activities with Asp477 and a single Mg(2+) ion. SN - 1364-548X UR - https://www.unboundmedicine.com/medline/citation/25272278/The_phosphatase_mechanism_of_bifunctional_kinase/phosphatase_AceK_ L2 - https://doi.org/10.1039/c4cc05375c DB - PRIME DP - Unbound Medicine ER -