Tags

Type your tag names separated by a space and hit enter

The N-methyl-D-aspartate receptor, a precursor to N-methyl-D-aspartate receptor encephalitis, is found in the squamous tissue of ovarian teratomas.
Int J Gynecol Pathol. 2014 Nov; 33(6):598-606.IJ

Abstract

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common antibody-mediated limbic encephalitis and is associated with underlying ovarian teratoma. Previous studies suggest that expression of NMDAR on teratoma neural tissue initiates an autoimmune response to NMDAR in the brain. As some teratomas of patients with anti-NMDAR encephalitis lack neuronal tissue, we questioned if there could be an alternate mechanism of the disease. We performed immunohistochemical analyses for NMDAR and correlated its expression with histology on 10 control teratomas and 5 teratomas associated with anti-NMDAR encephalitis. Both control and case teratomas expressed NMDAR-bearing neural tissue. All 15 teratomas contained large amounts of NMDAR bearing squamous epithelium; in 2 cases this was the only tissue expressing NMDAR. NMDAR-bearing neural tissue is not the sole source of encephalitis in all patients. Furthermore, we speculate that NMDAR expression by squamous epithelium may contribute to the disease development in some patients.

Authors+Show Affiliations

Vincent Department of Obstetrics and Gynecology (R.M.C., M.P.L., W.B.G., B.R.R.), Vincent Center for Reproductive Biology Vincent Department of Obstetrics & Gynecology, Gynecologic Oncology Division, Massachusetts General Hospital (R.M.C., W.B.G., B.R.R.) Department of Pathology and Department of Obstetrics, Gynecology and Reproductive Biology (L.R.Z.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Obstetrics, Gynecology and Reproductive Biology (R.M.C., M.P.L., R.K., W.B.G., B.R.R.), Harvard Medical School, Boston, Massachusetts.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25272299

Citation

Clark, Rachel M., et al. "The N-methyl-D-aspartate Receptor, a Precursor to N-methyl-D-aspartate Receptor Encephalitis, Is Found in the Squamous Tissue of Ovarian Teratomas." International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, vol. 33, no. 6, 2014, pp. 598-606.
Clark RM, Lynch MP, Kolp R, et al. The N-methyl-D-aspartate receptor, a precursor to N-methyl-D-aspartate receptor encephalitis, is found in the squamous tissue of ovarian teratomas. Int J Gynecol Pathol. 2014;33(6):598-606.
Clark, R. M., Lynch, M. P., Kolp, R., Zukerberg, L. R., Growdon, W. B., & Rueda, B. R. (2014). The N-methyl-D-aspartate receptor, a precursor to N-methyl-D-aspartate receptor encephalitis, is found in the squamous tissue of ovarian teratomas. International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, 33(6), 598-606. https://doi.org/10.1097/PGP.0000000000000104
Clark RM, et al. The N-methyl-D-aspartate Receptor, a Precursor to N-methyl-D-aspartate Receptor Encephalitis, Is Found in the Squamous Tissue of Ovarian Teratomas. Int J Gynecol Pathol. 2014;33(6):598-606. PubMed PMID: 25272299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The N-methyl-D-aspartate receptor, a precursor to N-methyl-D-aspartate receptor encephalitis, is found in the squamous tissue of ovarian teratomas. AU - Clark,Rachel M, AU - Lynch,Maureen P, AU - Kolp,Rebecca, AU - Zukerberg,Lawrence R, AU - Growdon,Whitfield B, AU - Rueda,Bo R, PY - 2014/10/2/entrez PY - 2014/10/2/pubmed PY - 2015/6/9/medline SP - 598 EP - 606 JF - International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists JO - Int J Gynecol Pathol VL - 33 IS - 6 N2 - Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common antibody-mediated limbic encephalitis and is associated with underlying ovarian teratoma. Previous studies suggest that expression of NMDAR on teratoma neural tissue initiates an autoimmune response to NMDAR in the brain. As some teratomas of patients with anti-NMDAR encephalitis lack neuronal tissue, we questioned if there could be an alternate mechanism of the disease. We performed immunohistochemical analyses for NMDAR and correlated its expression with histology on 10 control teratomas and 5 teratomas associated with anti-NMDAR encephalitis. Both control and case teratomas expressed NMDAR-bearing neural tissue. All 15 teratomas contained large amounts of NMDAR bearing squamous epithelium; in 2 cases this was the only tissue expressing NMDAR. NMDAR-bearing neural tissue is not the sole source of encephalitis in all patients. Furthermore, we speculate that NMDAR expression by squamous epithelium may contribute to the disease development in some patients. SN - 1538-7151 UR - https://www.unboundmedicine.com/medline/citation/25272299/The_N_methyl_D_aspartate_receptor_a_precursor_to_N_methyl_D_aspartate_receptor_encephalitis_is_found_in_the_squamous_tissue_of_ovarian_teratomas_ L2 - https://doi.org/10.1097/PGP.0000000000000104 DB - PRIME DP - Unbound Medicine ER -