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Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer's disease animal model.

Abstract

Accumulating research supports the neuroprotective effects of pomegranate (Punica granatum) juice and extracts against Alzheimer's disease (AD) but there is limited data available in animal models. Here we investigated the effects of a standardized pomegranate extract (PE) on AD pathology in an aged transgenic AD animal model (R1.40).The mice (age 24-30 months) received either PE (at 100 and 200 mg/kg) or a control solution daily for three weeks, and were evaluated in the Morris water maze and the Y-maze for improvements in spatial long-term and working memory functions. Cortical amyloid-β precursor protein (APP) and amyloid-β (Aβ) levels, along with other relevant biomarkers for AD, were measured in brain tissues. PE did not improve cognitive performance of the mice, but altered levels and ratio of the Aβ42 and Aβ40 peptides which would favor a diminution in AD pathogenesis. Further analysis revealed that this reversal could be the product of the modification of γ-secretase enzyme activity, the enzyme involved in the generation of these Aβ isoforms. Our findings support a specific anti-amyloidogenic mechanism of a pomegranate extract in this aged AD animal model.

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  • Authors+Show Affiliations

    , , , , ,

    7 Greenhouse Road, Kingston, RI, United States. nzawia@uri.edu.

    Source

    Current Alzheimer research 11:9 2014 pg 834-43

    MeSH

    Aging
    Alzheimer Disease
    Amyloid Precursor Protein Secretases
    Amyloid beta-Peptides
    Amyloid beta-Protein Precursor
    Animals
    Biomarkers
    Brain
    Disease Models, Animal
    Female
    Maze Learning
    Memory, Long-Term
    Memory, Short-Term
    Mice, Transgenic
    Neuroprotective Agents
    Peptide Fragments
    Phytotherapy
    Plant Extracts
    Punicaceae
    Spatial Memory

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    25274111

    Citation

    Ahmed, Aseef H., et al. "Pomegranate Extract Modulates Processing of Amyloid-β Precursor Protein in an Aged Alzheimer's Disease Animal Model." Current Alzheimer Research, vol. 11, no. 9, 2014, pp. 834-43.
    Ahmed AH, Subaiea GM, Eid A, et al. Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer's disease animal model. Curr Alzheimer Res. 2014;11(9):834-43.
    Ahmed, A. H., Subaiea, G. M., Eid, A., Li, L., Seeram, N. P., & Zawia, N. H. (2014). Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer's disease animal model. Current Alzheimer Research, 11(9), pp. 834-43.
    Ahmed AH, et al. Pomegranate Extract Modulates Processing of Amyloid-β Precursor Protein in an Aged Alzheimer's Disease Animal Model. Curr Alzheimer Res. 2014;11(9):834-43. PubMed PMID: 25274111.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer's disease animal model. AU - Ahmed,Aseef H, AU - Subaiea,Gehad M, AU - Eid,Aseel, AU - Li,Liya, AU - Seeram,Navindra P, AU - Zawia,Nasser H, PY - 2014/06/26/received PY - 2014/09/10/revised PY - 2014/09/15/accepted PY - 2014/10/3/entrez PY - 2014/10/3/pubmed PY - 2015/7/24/medline SP - 834 EP - 43 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 11 IS - 9 N2 - Accumulating research supports the neuroprotective effects of pomegranate (Punica granatum) juice and extracts against Alzheimer's disease (AD) but there is limited data available in animal models. Here we investigated the effects of a standardized pomegranate extract (PE) on AD pathology in an aged transgenic AD animal model (R1.40).The mice (age 24-30 months) received either PE (at 100 and 200 mg/kg) or a control solution daily for three weeks, and were evaluated in the Morris water maze and the Y-maze for improvements in spatial long-term and working memory functions. Cortical amyloid-β precursor protein (APP) and amyloid-β (Aβ) levels, along with other relevant biomarkers for AD, were measured in brain tissues. PE did not improve cognitive performance of the mice, but altered levels and ratio of the Aβ42 and Aβ40 peptides which would favor a diminution in AD pathogenesis. Further analysis revealed that this reversal could be the product of the modification of γ-secretase enzyme activity, the enzyme involved in the generation of these Aβ isoforms. Our findings support a specific anti-amyloidogenic mechanism of a pomegranate extract in this aged AD animal model. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/25274111/Pomegranate_extract_modulates_processing_of_amyloid_β_precursor_protein_in_an_aged_Alzheimer's_disease_animal_model_ L2 - http://www.eurekaselect.com/125061/article DB - PRIME DP - Unbound Medicine ER -