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Correlates of hepcidin and NTBI according to HFE status in patients referred to a liver centre.
Acta Haematol. 2015; 133(2):155-61.AH

Abstract

BACKGROUND/AIMS

Innately low hepcidin levels lead to iron overload in HFE-associated hereditary haemochromatosis.

METHODS

This study compared hepcidin and non-transferrin bound iron (NTBI) levels in untreated iron-loaded and non-iron-loaded C282Y homozygotes to levels in C282Y/H63D compound heterozygotes and individuals with other HFE genotypes associated with less risk of iron overload.

RESULTS

As the genotypic risk for iron overload increased, transferrin saturation and serum NTBI levels increased while serum hepcidin levels decreased. Overweight and obese male C282Y homozygotes had significantly higher hepcidin levels than male C282Y homozygotes with a normal BMI. Pearson product-moment analysis showed that serum hepcidin levels significantly correlated with HFE status, serum ferritin, age, NTBI, transferrin saturation, gender and BMI. Subsequent multiple regression analysis showed that HFE status and serum ferritin were significant independent correlates of serum hepcidin levels.

CONCLUSIONS

In summary, this study has shown that while serum ferritin and HFE status are the most important determinants of hepcidin levels, factors such age, gender, BMI, transferrin saturation and NTBI all interact closely in the matrix of homeostatic iron balance.

Authors+Show Affiliations

Liver Centre, Mater Misericordiae University Hospital, Dublin, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

25277871

Citation

Ryan, Eleanor, et al. "Correlates of Hepcidin and NTBI According to HFE Status in Patients Referred to a Liver Centre." Acta Haematologica, vol. 133, no. 2, 2015, pp. 155-61.
Ryan E, Ryan JD, Russell J, et al. Correlates of hepcidin and NTBI according to HFE status in patients referred to a liver centre. Acta Haematol. 2015;133(2):155-61.
Ryan, E., Ryan, J. D., Russell, J., Coughlan, B., Tjalsma, H., Swinkels, D. W., Stewart, S., & Crowe, J. P. (2015). Correlates of hepcidin and NTBI according to HFE status in patients referred to a liver centre. Acta Haematologica, 133(2), 155-61. https://doi.org/10.1159/000363490
Ryan E, et al. Correlates of Hepcidin and NTBI According to HFE Status in Patients Referred to a Liver Centre. Acta Haematol. 2015;133(2):155-61. PubMed PMID: 25277871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlates of hepcidin and NTBI according to HFE status in patients referred to a liver centre. AU - Ryan,Eleanor, AU - Ryan,John D, AU - Russell,Jennifer, AU - Coughlan,Barbara, AU - Tjalsma,Harold, AU - Swinkels,Dorine W, AU - Stewart,Stephen, AU - Crowe,John P, Y1 - 2014/09/26/ PY - 2014/03/04/received PY - 2014/05/08/accepted PY - 2014/10/4/entrez PY - 2014/10/4/pubmed PY - 2015/4/11/medline SP - 155 EP - 61 JF - Acta haematologica JO - Acta Haematol VL - 133 IS - 2 N2 - BACKGROUND/AIMS: Innately low hepcidin levels lead to iron overload in HFE-associated hereditary haemochromatosis. METHODS: This study compared hepcidin and non-transferrin bound iron (NTBI) levels in untreated iron-loaded and non-iron-loaded C282Y homozygotes to levels in C282Y/H63D compound heterozygotes and individuals with other HFE genotypes associated with less risk of iron overload. RESULTS: As the genotypic risk for iron overload increased, transferrin saturation and serum NTBI levels increased while serum hepcidin levels decreased. Overweight and obese male C282Y homozygotes had significantly higher hepcidin levels than male C282Y homozygotes with a normal BMI. Pearson product-moment analysis showed that serum hepcidin levels significantly correlated with HFE status, serum ferritin, age, NTBI, transferrin saturation, gender and BMI. Subsequent multiple regression analysis showed that HFE status and serum ferritin were significant independent correlates of serum hepcidin levels. CONCLUSIONS: In summary, this study has shown that while serum ferritin and HFE status are the most important determinants of hepcidin levels, factors such age, gender, BMI, transferrin saturation and NTBI all interact closely in the matrix of homeostatic iron balance. SN - 1421-9662 UR - https://www.unboundmedicine.com/medline/citation/25277871/Correlates_of_hepcidin_and_NTBI_according_to_HFE_status_in_patients_referred_to_a_liver_centre_ L2 - https://www.karger.com?DOI=10.1159/000363490 DB - PRIME DP - Unbound Medicine ER -