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Role of Helicobacter pylori infection on nutrition and metabolism.
World J Gastroenterol 2014; 20(36):12809-17WJ

Abstract

Helicobacter pylori (H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome.

Authors+Show Affiliations

Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25278679

Citation

Franceschi, Francesco, et al. "Role of Helicobacter Pylori Infection On Nutrition and Metabolism." World Journal of Gastroenterology, vol. 20, no. 36, 2014, pp. 12809-17.
Franceschi F, Annalisa T, Teresa DR, et al. Role of Helicobacter pylori infection on nutrition and metabolism. World J Gastroenterol. 2014;20(36):12809-17.
Franceschi, F., Annalisa, T., Teresa, D. R., Giovanna, D., Ianiro, G., Franco, S., ... Antonio, G. (2014). Role of Helicobacter pylori infection on nutrition and metabolism. World Journal of Gastroenterology, 20(36), pp. 12809-17. doi:10.3748/wjg.v20.i36.12809.
Franceschi F, et al. Role of Helicobacter Pylori Infection On Nutrition and Metabolism. World J Gastroenterol. 2014 Sep 28;20(36):12809-17. PubMed PMID: 25278679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Helicobacter pylori infection on nutrition and metabolism. AU - Franceschi,Francesco, AU - Annalisa,Tortora, AU - Teresa,Di Rienzo, AU - Giovanna,D'Angelo, AU - Ianiro,Gianluca, AU - Franco,Scaldaferri, AU - Viviana,Gerardi, AU - Valentina,Tesori, AU - Riccardo,Lopetuso Loris, AU - Antonio,Gasbarrini, PY - 2014/01/16/received PY - 2014/03/12/revised PY - 2014/05/23/accepted PY - 2014/10/4/entrez PY - 2014/10/4/pubmed PY - 2015/6/4/medline KW - Gastrointestinal hormones KW - Helicobacter pylori KW - Malabsorption KW - Metabolic syndrome SP - 12809 EP - 17 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 36 N2 - Helicobacter pylori (H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/25278679/full_citation L2 - http://www.wjgnet.com/1007-9327/full/v20/i36/12809.htm DB - PRIME DP - Unbound Medicine ER -