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Role of Helicobacter pylori infection on nutrition and metabolism.

Abstract

Helicobacter pylori (H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome.

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  • Authors+Show Affiliations

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    ,

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    Francesco Franceschi, Department of Emergency, Internal Medicine Institute, Catholic University of Sacred Heart, 00168 Rome, Italy.

    Source

    World journal of gastroenterology 20:36 2014 Sep 28 pg 12809-17

    MeSH

    Animals
    Child
    Child Nutrition Disorders
    Child Nutritional Physiological Phenomena
    Energy Metabolism
    Gastric Absorption
    Gastric Mucosa
    Gastrointestinal Hormones
    Growth Disorders
    Helicobacter Infections
    Helicobacter pylori
    Host-Pathogen Interactions
    Humans
    Malnutrition
    Metabolic Syndrome
    Nutritional Status
    Stomach

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    25278679

    Citation

    Franceschi, Francesco, et al. "Role of Helicobacter Pylori Infection On Nutrition and Metabolism." World Journal of Gastroenterology, vol. 20, no. 36, 2014, pp. 12809-17.
    Franceschi F, Annalisa T, Teresa DR, et al. Role of Helicobacter pylori infection on nutrition and metabolism. World J Gastroenterol. 2014;20(36):12809-17.
    Franceschi, F., Annalisa, T., Teresa, D. R., Giovanna, D., Ianiro, G., Franco, S., ... Antonio, G. (2014). Role of Helicobacter pylori infection on nutrition and metabolism. World Journal of Gastroenterology, 20(36), pp. 12809-17. doi:10.3748/wjg.v20.i36.12809.
    Franceschi F, et al. Role of Helicobacter Pylori Infection On Nutrition and Metabolism. World J Gastroenterol. 2014 Sep 28;20(36):12809-17. PubMed PMID: 25278679.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of Helicobacter pylori infection on nutrition and metabolism. AU - Franceschi,Francesco, AU - Annalisa,Tortora, AU - Teresa,Di Rienzo, AU - Giovanna,D'Angelo, AU - Ianiro,Gianluca, AU - Franco,Scaldaferri, AU - Viviana,Gerardi, AU - Valentina,Tesori, AU - Riccardo,Lopetuso Loris, AU - Antonio,Gasbarrini, PY - 2014/01/16/received PY - 2014/03/12/revised PY - 2014/05/23/accepted PY - 2014/10/4/entrez PY - 2014/10/4/pubmed PY - 2015/6/4/medline KW - Gastrointestinal hormones KW - Helicobacter pylori KW - Malabsorption KW - Metabolic syndrome SP - 12809 EP - 17 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 36 N2 - Helicobacter pylori (H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/25278679/full_citation L2 - http://www.wjgnet.com/1007-9327/full/v20/i36/12809.htm DB - PRIME DP - Unbound Medicine ER -