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Dental plaque, gingival inflammation and tooth -discolouration with different commercial -formulations of 0.2% chlorhexidine rinse: a double-blind randomised controlled clinical trial.
Oral Health Prev Dent 2015; 13(2):101-11OH

Abstract

PURPOSE

To investigate the efficacy of various formulations of chlorhexidine 0.2% (CHX) in terms of plaque and gingival bleeding control compared to each other and to saline rinse (CTRL) over a 35-day rinsing period.

MATERIALS AND METHODS

Seventy subjects were randomly allocated to one of 4 groups rinsing twice daily for 35 days. The different groups used CHX 0.2% rinse with alcohol (CHX1) and without alcohol (CHX2), with an antidiscolouration system (CHX3) or saline rinse (CTRL). Clinical examinations to evaluate full-mouth plaque scores (FMPS) and periodontal parameters were performed at baseline, 7, 21 and 35 days. Tooth discolouration (TD) was measured at each time point using digital photographs and spectrophotometric analysis.

RESULTS

At 35 days, CTRL showed the highest levels of plaque. The mean changes in FMPS from baseline were 69.8% ± 6.8 for CHX1, 57.5% ± 9.8 for CHX2, 43.7% ± 9.8 for CHX3 and 25.8% ± 7.7 for CTRL. Statistically significant differences were demonstrated between CHX1 and CHX3 (p = 0.02), CHX2 vs CHX3 (p ≤ 0.05) and CHX1/CHX2 vs CHX3 (p < 0.05). In contrast, CHX3 appeared more effective in reducing inflammatory indexes. TD increased over time in 60% to 70% of participants, although lighter staining was found in the CHX3 group. Greater FMPS reduction was observed in participants with staining vs without staining (26.0% ± 12.3, p = 0.04).

CONCLUSION

Conventional CHX appeared more effective in terms of plaque reduction. Interestingly, the newest formulation showed a higher control of gingival inflammation. Staining was associated with lower plaque levels.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25279395

Citation

Graziani, Filippo, et al. "Dental Plaque, Gingival Inflammation and Tooth -discolouration With Different Commercial -formulations of 0.2% Chlorhexidine Rinse: a Double-blind Randomised Controlled Clinical Trial." Oral Health & Preventive Dentistry, vol. 13, no. 2, 2015, pp. 101-11.
Graziani F, Gabriele M, D'Aiuto F, et al. Dental plaque, gingival inflammation and tooth -discolouration with different commercial -formulations of 0.2% chlorhexidine rinse: a double-blind randomised controlled clinical trial. Oral Health Prev Dent. 2015;13(2):101-11.
Graziani, F., Gabriele, M., D'Aiuto, F., Suvan, J., Tonelli, M., & Cei, S. (2015). Dental plaque, gingival inflammation and tooth -discolouration with different commercial -formulations of 0.2% chlorhexidine rinse: a double-blind randomised controlled clinical trial. Oral Health & Preventive Dentistry, 13(2), pp. 101-11. doi:10.3290/j.ohpd.a32827.
Graziani F, et al. Dental Plaque, Gingival Inflammation and Tooth -discolouration With Different Commercial -formulations of 0.2% Chlorhexidine Rinse: a Double-blind Randomised Controlled Clinical Trial. Oral Health Prev Dent. 2015;13(2):101-11. PubMed PMID: 25279395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dental plaque, gingival inflammation and tooth -discolouration with different commercial -formulations of 0.2% chlorhexidine rinse: a double-blind randomised controlled clinical trial. AU - Graziani,Filippo, AU - Gabriele,Mario, AU - D'Aiuto,Francesco, AU - Suvan,Jeanie, AU - Tonelli,Matteo, AU - Cei,Silvia, PY - 2014/10/4/entrez PY - 2014/10/4/pubmed PY - 2015/7/15/medline SP - 101 EP - 11 JF - Oral health & preventive dentistry JO - Oral Health Prev Dent VL - 13 IS - 2 N2 - PURPOSE: To investigate the efficacy of various formulations of chlorhexidine 0.2% (CHX) in terms of plaque and gingival bleeding control compared to each other and to saline rinse (CTRL) over a 35-day rinsing period. MATERIALS AND METHODS: Seventy subjects were randomly allocated to one of 4 groups rinsing twice daily for 35 days. The different groups used CHX 0.2% rinse with alcohol (CHX1) and without alcohol (CHX2), with an antidiscolouration system (CHX3) or saline rinse (CTRL). Clinical examinations to evaluate full-mouth plaque scores (FMPS) and periodontal parameters were performed at baseline, 7, 21 and 35 days. Tooth discolouration (TD) was measured at each time point using digital photographs and spectrophotometric analysis. RESULTS: At 35 days, CTRL showed the highest levels of plaque. The mean changes in FMPS from baseline were 69.8% ± 6.8 for CHX1, 57.5% ± 9.8 for CHX2, 43.7% ± 9.8 for CHX3 and 25.8% ± 7.7 for CTRL. Statistically significant differences were demonstrated between CHX1 and CHX3 (p = 0.02), CHX2 vs CHX3 (p ≤ 0.05) and CHX1/CHX2 vs CHX3 (p < 0.05). In contrast, CHX3 appeared more effective in reducing inflammatory indexes. TD increased over time in 60% to 70% of participants, although lighter staining was found in the CHX3 group. Greater FMPS reduction was observed in participants with staining vs without staining (26.0% ± 12.3, p = 0.04). CONCLUSION: Conventional CHX appeared more effective in terms of plaque reduction. Interestingly, the newest formulation showed a higher control of gingival inflammation. Staining was associated with lower plaque levels. SN - 1602-1622 UR - https://www.unboundmedicine.com/medline/citation/25279395/Dental_plaque_gingival_inflammation_and_tooth__discolouration_with_different_commercial__formulations_of_0_2_chlorhexidine_rinse:_a_double_blind_randomised_controlled_clinical_trial_ L2 - http://ohpd.quintessenz.de/index.php?doc=abstract&amp;abstractID=32827/ DB - PRIME DP - Unbound Medicine ER -