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Dietary fatty acids intake and mortality in patients with heart failure.
Nutrition 2014 Nov-Dec; 30(11-12):1366-71N

Abstract

OBJECTIVE

Dietary strategies in heart failure (HF) are focused on sodium and fluid restriction to minimize the risk for acute volume overload episodes. However, the importance of dietary factors beyond sodium intake in the prognosis of the disease is uncertain. The purpose of this study was to evaluate the association of macro- and micronutrients intake on 1-y mortality in patients with HF.

METHODS

A secondary analysis of 203 patients with chronic HF enrolled in a randomized trial of sodium reduction was completed. Patients with a complete 3-d food record at baseline were included in this analysis (N = 118); both control and intervention arms were combined. Three-d mean dietary intake was estimated. Cox multivariable regression analysis was used to evaluate the association between dietary factors and 1-y mortality.

RESULTS

Among the 118 included patients, 54% were men, median (25th-75th percentiles) age 66 y (52-75 y), median ejection fraction 45% (30%-60%), and ischemic etiology present in 49% of patients. The association with 1-y mortality was significant for both polyunsaturated fatty acids (PUFA; adjusted hazard ratio [HR], 0.67; 95% confidence interval [CI]. 0.51-0.86 for intake as percentage of daily energy) and saturated fatty acids (SFA; adjusted HR, 1.15; 95% CI, 1.03-1.30 for intake as percentage of daily energy). Median of intake as percentage of daily energy was 5.3% for PUFAs and 8.2% for SFAs.

CONCLUSIONS

Intake of PUFAs and SFAs was independently associated with 1-y all-cause mortality in patients with chronic HF. Limiting dietary SFA and increasing PUFA intake may be advisable in this population.

Authors+Show Affiliations

University of Alberta, Edmonton, Canada.Instituto Nacional de Ciencias Medicas y Nutricion "SZ" Mexico City, Mexico.Instituto Nacional de Ciencias Medicas y Nutricion "SZ" Mexico City, Mexico.Canadian VIGOUR Centre at the University of Alberta, Edmonton, Canada.Canadian VIGOUR Centre at the University of Alberta, Edmonton, Canada.University of Alberta, Edmonton, Canada; Canadian VIGOUR Centre at the University of Alberta, Edmonton, Canada. Electronic address: jae2@ualberta.ca.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25280414

Citation

Colin-Ramirez, Eloisa, et al. "Dietary Fatty Acids Intake and Mortality in Patients With Heart Failure." Nutrition (Burbank, Los Angeles County, Calif.), vol. 30, no. 11-12, 2014, pp. 1366-71.
Colin-Ramirez E, Castillo-Martinez L, Orea-Tejeda A, et al. Dietary fatty acids intake and mortality in patients with heart failure. Nutrition. 2014;30(11-12):1366-71.
Colin-Ramirez, E., Castillo-Martinez, L., Orea-Tejeda, A., Zheng, Y., Westerhout, C. M., & Ezekowitz, J. A. (2014). Dietary fatty acids intake and mortality in patients with heart failure. Nutrition (Burbank, Los Angeles County, Calif.), 30(11-12), pp. 1366-71. doi:10.1016/j.nut.2014.04.006.
Colin-Ramirez E, et al. Dietary Fatty Acids Intake and Mortality in Patients With Heart Failure. Nutrition. 2014;30(11-12):1366-71. PubMed PMID: 25280414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fatty acids intake and mortality in patients with heart failure. AU - Colin-Ramirez,Eloisa, AU - Castillo-Martinez,Lilia, AU - Orea-Tejeda,Arturo, AU - Zheng,Yinggan, AU - Westerhout,Cynthia M, AU - Ezekowitz,Justin A, Y1 - 2014/04/19/ PY - 2014/01/11/received PY - 2014/04/01/revised PY - 2014/04/02/accepted PY - 2014/10/5/entrez PY - 2014/10/5/pubmed PY - 2015/6/2/medline KW - Dietary intake KW - diet KW - dietary fats KW - nutrition SP - 1366 EP - 71 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 30 IS - 11-12 N2 - OBJECTIVE: Dietary strategies in heart failure (HF) are focused on sodium and fluid restriction to minimize the risk for acute volume overload episodes. However, the importance of dietary factors beyond sodium intake in the prognosis of the disease is uncertain. The purpose of this study was to evaluate the association of macro- and micronutrients intake on 1-y mortality in patients with HF. METHODS: A secondary analysis of 203 patients with chronic HF enrolled in a randomized trial of sodium reduction was completed. Patients with a complete 3-d food record at baseline were included in this analysis (N = 118); both control and intervention arms were combined. Three-d mean dietary intake was estimated. Cox multivariable regression analysis was used to evaluate the association between dietary factors and 1-y mortality. RESULTS: Among the 118 included patients, 54% were men, median (25th-75th percentiles) age 66 y (52-75 y), median ejection fraction 45% (30%-60%), and ischemic etiology present in 49% of patients. The association with 1-y mortality was significant for both polyunsaturated fatty acids (PUFA; adjusted hazard ratio [HR], 0.67; 95% confidence interval [CI]. 0.51-0.86 for intake as percentage of daily energy) and saturated fatty acids (SFA; adjusted HR, 1.15; 95% CI, 1.03-1.30 for intake as percentage of daily energy). Median of intake as percentage of daily energy was 5.3% for PUFAs and 8.2% for SFAs. CONCLUSIONS: Intake of PUFAs and SFAs was independently associated with 1-y all-cause mortality in patients with chronic HF. Limiting dietary SFA and increasing PUFA intake may be advisable in this population. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25280414/Dietary_fatty_acids_intake_and_mortality_in_patients_with_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00197-X DB - PRIME DP - Unbound Medicine ER -