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Dietary fiber, kidney function, inflammation, and mortality risk.
Clin J Am Soc Nephrol. 2014 Dec 05; 9(12):2104-10.CJ

Abstract

BACKGROUND AND OBJECTIVES

In the United States population, high dietary fiber intake has been associated with a lower risk of inflammation and mortality in individuals with kidney dysfunction. This study aimed to expand such findings to a Northern European population.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

Dietary fiber intake was calculated from 7-day dietary records in 1110 participants aged 70-71 years from the Uppsala Longitudinal Study of Adult Men (examinations performed during 1991-1995). Dietary fiber was adjusted for total energy intake by the residual method. Renal function was estimated from the concentration of serum cystatin C, and deaths were registered prospectively during a median follow-up of 10.0 years.

RESULTS

Dietary fiber independently and directly associated with eGFR (adjusted difference, 2.6 ml/min per 1.73 m(2) per 10 g/d higher; 95% confidence interval [95% CI], 0.3 to 4.9). The odds of C-reactive protein >3 mg/L were lower (linear trend, P=0.002) with higher fiber quartiles. During follow-up, 300 participants died (incidence rate of 2.87 per 100 person-years at risk). Multiplicative interactions were observed between dietary fiber intake and kidney dysfunction in the prediction of mortality. Higher dietary fiber was associated with lower mortality in unadjusted analysis. These associations were stronger in participants with kidney dysfunction (eGFR<60 ml/min per 1.73 m(2)) (hazard ratio [HR], 0.58; 95% CI, 0.35 to 0.98) than in those without (HR, 1.30; 95% CI, 0.76 to 2.22; P value for interaction, P=0.04), and were mainly explained by a lower incidence of cancer-related deaths (0.25; 95% CI, 0.10 to 0.65) in individuals with kidney dysfunction versus individuals with an eGFR≥60 ml/min per 1.73 m(2) (1.61; 95% CI, 0.69 to 3.74; P value for interaction, P=0.01).

CONCLUSIONS

High dietary fiber was associated with better kidney function and lower inflammation in community-dwelling elderly men from Sweden. High dietary fiber was also associated with lower (cancer) mortality risk, especially in individuals with kidney dysfunction.

Authors+Show Affiliations

Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, and Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China;Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, and Division of Nephrology, Peking University Shenzhen Hospital, Peking University, Shenzhen, China;Sections of Clinical Nutrition and Metabolism and.Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, and.Sections of Clinical Nutrition and Metabolism and.Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden; and School of Health and Social Studies, Dalarna University, Falun, Sweden.Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, and.Sections of Clinical Nutrition and Metabolism and.Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; juan.jesus.carrero@ki.se.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25280496

Citation

Xu, Hong, et al. "Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk." Clinical Journal of the American Society of Nephrology : CJASN, vol. 9, no. 12, 2014, pp. 2104-10.
Xu H, Huang X, Risérus U, et al. Dietary fiber, kidney function, inflammation, and mortality risk. Clin J Am Soc Nephrol. 2014;9(12):2104-10.
Xu, H., Huang, X., Risérus, U., Krishnamurthy, V. M., Cederholm, T., Arnlöv, J., Lindholm, B., Sjögren, P., & Carrero, J. J. (2014). Dietary fiber, kidney function, inflammation, and mortality risk. Clinical Journal of the American Society of Nephrology : CJASN, 9(12), 2104-10. https://doi.org/10.2215/CJN.02260314
Xu H, et al. Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk. Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2104-10. PubMed PMID: 25280496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber, kidney function, inflammation, and mortality risk. AU - Xu,Hong, AU - Huang,Xiaoyan, AU - Risérus,Ulf, AU - Krishnamurthy,Vidya M, AU - Cederholm,Tommy, AU - Arnlöv,Johan, AU - Lindholm,Bengt, AU - Sjögren,Per, AU - Carrero,Juan Jesús, Y1 - 2014/10/03/ PY - 2014/10/5/entrez PY - 2014/10/5/pubmed PY - 2015/8/22/medline KW - CKD KW - GFR KW - chronic inflammation KW - mortality risk KW - nutrition SP - 2104 EP - 10 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 9 IS - 12 N2 - BACKGROUND AND OBJECTIVES: In the United States population, high dietary fiber intake has been associated with a lower risk of inflammation and mortality in individuals with kidney dysfunction. This study aimed to expand such findings to a Northern European population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Dietary fiber intake was calculated from 7-day dietary records in 1110 participants aged 70-71 years from the Uppsala Longitudinal Study of Adult Men (examinations performed during 1991-1995). Dietary fiber was adjusted for total energy intake by the residual method. Renal function was estimated from the concentration of serum cystatin C, and deaths were registered prospectively during a median follow-up of 10.0 years. RESULTS: Dietary fiber independently and directly associated with eGFR (adjusted difference, 2.6 ml/min per 1.73 m(2) per 10 g/d higher; 95% confidence interval [95% CI], 0.3 to 4.9). The odds of C-reactive protein >3 mg/L were lower (linear trend, P=0.002) with higher fiber quartiles. During follow-up, 300 participants died (incidence rate of 2.87 per 100 person-years at risk). Multiplicative interactions were observed between dietary fiber intake and kidney dysfunction in the prediction of mortality. Higher dietary fiber was associated with lower mortality in unadjusted analysis. These associations were stronger in participants with kidney dysfunction (eGFR<60 ml/min per 1.73 m(2)) (hazard ratio [HR], 0.58; 95% CI, 0.35 to 0.98) than in those without (HR, 1.30; 95% CI, 0.76 to 2.22; P value for interaction, P=0.04), and were mainly explained by a lower incidence of cancer-related deaths (0.25; 95% CI, 0.10 to 0.65) in individuals with kidney dysfunction versus individuals with an eGFR≥60 ml/min per 1.73 m(2) (1.61; 95% CI, 0.69 to 3.74; P value for interaction, P=0.01). CONCLUSIONS: High dietary fiber was associated with better kidney function and lower inflammation in community-dwelling elderly men from Sweden. High dietary fiber was also associated with lower (cancer) mortality risk, especially in individuals with kidney dysfunction. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/25280496/Dietary_fiber_kidney_function_inflammation_and_mortality_risk_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=25280496 DB - PRIME DP - Unbound Medicine ER -