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No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome.
Arch Gynecol Obstet. 2015 May; 291(5):1075-80.AG

Abstract

PURPOSE

To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS).

METHODS

Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups.

RESULTS

The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 ± 2.29 vs. 10.22 ± 2.25 pmol/L, P = 0.026). The mean CIMT was higher in PCOS group than control group (0.52 ± 0.058 vs. 0.45 ± 0.059 mm, P < 0.01). The mean brachial artery FMD was lower in PCOS group (0.068 ± 0.022 vs. 0.055 ± 0.029, P = 0.017).

CONCLUSIONS

We found high osteoprotogerin concentrations, increased CIMT and decreased FMD, in women with PCOS. However, there was no correlation between osteoprotegerin and cardiovascular risk markers.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Abali R
Department of Gynecology and Obstetrics, Faculty of Medicine, Namik Kemal University, 100. YilMah. Barbaros Cad, No: 132, Tekirdag, Turkey, remziabali@yahoo.com.
Tasdemir N
No affiliation info available
Alpsoy S
No affiliation info available
Tasdemir UG
No affiliation info available
Guzel S
No affiliation info available
Yuksel MA
No affiliation info available
Temel Yuksel I
No affiliation info available
Yilmaz M
No affiliation info available

MeSH

AdultBody Mass IndexBrachial ArteryCardiovascular DiseasesCarotid Intima-Media ThicknessCase-Control StudiesCross-Sectional StudiesEndothelium, VascularFemaleHumansLipidsObesityOsteoprotegerinPolycystic Ovary SyndromeRisk FactorsVasodilation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25280574

Citation

Abali, Remzi, et al. "No Relationship Between Osteoprotegerin Concentrations and Endothelial Dysfunction in Non-obese Women With and Without Polycystic Ovary Syndrome." Archives of Gynecology and Obstetrics, vol. 291, no. 5, 2015, pp. 1075-80.
Abali R, Tasdemir N, Alpsoy S, et al. No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome. Arch Gynecol Obstet. 2015;291(5):1075-80.
Abali, R., Tasdemir, N., Alpsoy, S., Tasdemir, U. G., Guzel, S., Yuksel, M. A., Temel Yuksel, I., & Yilmaz, M. (2015). No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 291(5), 1075-80. https://doi.org/10.1007/s00404-014-3499-7
Abali R, et al. No Relationship Between Osteoprotegerin Concentrations and Endothelial Dysfunction in Non-obese Women With and Without Polycystic Ovary Syndrome. Arch Gynecol Obstet. 2015;291(5):1075-80. PubMed PMID: 25280574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome. AU - Abali,Remzi, AU - Tasdemir,Nicel, AU - Alpsoy,Seref, AU - Tasdemir,Ufuk Göker, AU - Guzel,Savas, AU - Yuksel,Mehmet Aytac, AU - Temel Yuksel,Ilkbal, AU - Yilmaz,Murat, Y1 - 2014/10/04/ PY - 2013/05/04/received PY - 2014/09/25/accepted PY - 2014/10/5/entrez PY - 2014/10/5/pubmed PY - 2015/8/4/medline SP - 1075 EP - 80 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 291 IS - 5 N2 - PURPOSE: To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS). METHODS: Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups. RESULTS: The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 ± 2.29 vs. 10.22 ± 2.25 pmol/L, P = 0.026). The mean CIMT was higher in PCOS group than control group (0.52 ± 0.058 vs. 0.45 ± 0.059 mm, P < 0.01). The mean brachial artery FMD was lower in PCOS group (0.068 ± 0.022 vs. 0.055 ± 0.029, P = 0.017). CONCLUSIONS: We found high osteoprotogerin concentrations, increased CIMT and decreased FMD, in women with PCOS. However, there was no correlation between osteoprotegerin and cardiovascular risk markers. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/25280574/No_relationship_between_osteoprotegerin_concentrations_and_endothelial_dysfunction_in_non_obese_women_with_and_without_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -