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Quantification of acesulfame potassium in processed foods by quantitative 1H NMR.
Talanta. 2015 Jan; 131:712-8.T

Abstract

Acesulfame potassium (AceK), a high-intensity and non-caloric artificial sweetener, is used in various processed foods as a food additive. In this study, we established and validated a method for determining the AceK content in various processed foods by solvent extraction and quantitative (1)H NMR, using a certified reference material as the internal standard. In the recovery test, the proposed method gave satisfactory recoveries (88.4-99.6%) and repeatabilities (0.6-5.6%) for various processed foods. The limit of quantification was confirmed as 0.13 g kg(-1), which was sufficiently low for the purposes of monitoring AceK levels. In the analysis of commercially processed foods containing AceK, all AceK contents determined by the proposed method were in good agreement with those obtained by a conventional method based on dialysis and HPLC. Moreover, this method can achieve rapid quantification and yields analytical data with traceability to the International System of Units (SI) without the need for an authentic analyte standard. Therefore, the proposed method is a useful and practical tool for the determination of AceK in processed foods.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ohtsuki T
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. Electronic address: ohtsuki@nihs.go.jp.
Sato K
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Abe Y
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Sugimoto N
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Akiyama H
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.

MeSH

Chromatography, High Pressure LiquidFast FoodsFood ContaminationProton Magnetic Resonance SpectroscopySweetening AgentsThiazines

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25281163

Citation

Ohtsuki, Takashi, et al. "Quantification of Acesulfame Potassium in Processed Foods By Quantitative 1H NMR." Talanta, vol. 131, 2015, pp. 712-8.
Ohtsuki T, Sato K, Abe Y, et al. Quantification of acesulfame potassium in processed foods by quantitative 1H NMR. Talanta. 2015;131:712-8.
Ohtsuki, T., Sato, K., Abe, Y., Sugimoto, N., & Akiyama, H. (2015). Quantification of acesulfame potassium in processed foods by quantitative 1H NMR. Talanta, 131, 712-8. https://doi.org/10.1016/j.talanta.2014.08.002
Ohtsuki T, et al. Quantification of Acesulfame Potassium in Processed Foods By Quantitative 1H NMR. Talanta. 2015;131:712-8. PubMed PMID: 25281163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of acesulfame potassium in processed foods by quantitative 1H NMR. AU - Ohtsuki,Takashi, AU - Sato,Kyoko, AU - Abe,Yutaka, AU - Sugimoto,Naoki, AU - Akiyama,Hiroshi, Y1 - 2014/08/11/ PY - 2014/07/01/received PY - 2014/08/01/revised PY - 2014/08/02/accepted PY - 2014/10/5/entrez PY - 2014/10/5/pubmed PY - 2015/7/1/medline KW - Absolute quantification KW - Acesulfame potassium KW - Processed food KW - Quantitative NMR SP - 712 EP - 8 JF - Talanta JO - Talanta VL - 131 N2 - Acesulfame potassium (AceK), a high-intensity and non-caloric artificial sweetener, is used in various processed foods as a food additive. In this study, we established and validated a method for determining the AceK content in various processed foods by solvent extraction and quantitative (1)H NMR, using a certified reference material as the internal standard. In the recovery test, the proposed method gave satisfactory recoveries (88.4-99.6%) and repeatabilities (0.6-5.6%) for various processed foods. The limit of quantification was confirmed as 0.13 g kg(-1), which was sufficiently low for the purposes of monitoring AceK levels. In the analysis of commercially processed foods containing AceK, all AceK contents determined by the proposed method were in good agreement with those obtained by a conventional method based on dialysis and HPLC. Moreover, this method can achieve rapid quantification and yields analytical data with traceability to the International System of Units (SI) without the need for an authentic analyte standard. Therefore, the proposed method is a useful and practical tool for the determination of AceK in processed foods. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/25281163/Quantification_of_acesulfame_potassium_in_processed_foods_by_quantitative_1H_NMR_ DB - PRIME DP - Unbound Medicine ER -