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Discriminative and locomotor effects of five synthetic cathinones in rats and mice.
Psychopharmacology (Berl). 2015 Apr; 232(7):1197-205.P

Abstract

RATIONALE

Synthetic cathinones continue to be sold as "legal" alternatives to methamphetamine or cocaine. As these marginally legal compounds become controlled, suppliers move to other, unregulated compounds.

OBJECTIVES

The purpose of these experiments was to determine whether several temporarily controlled cathinone compounds, which are currently abused on the street, stimulate motor activity and have discriminative stimulus effects similar to cocaine and/or methamphetamine.

METHODS

Methcathinone, pentedrone, pentylone, 3-fluoromethcathinone (3-FMC), and 4-methylethcathinone (4-MEC) were tested for locomotor stimulant effects in mice and subsequently for substitution in rats trained to discriminate cocaine (10 mg/kg, i.p.) or methamphetamine (1 mg/kg, i.p.) from saline.

RESULTS

Methcathinone, pentedrone, and pentylone produced locomotor stimulant effects which lasted up to 6 h. In addition, pentylone produced convulsions and lethality at 100 mg/kg. 4-MEC produced locomotor stimulant effects which lasted up to 2 h. Methcathinone, pentedrone, pentylone, 3-FMC, and 4-MEC each produced discriminative stimulus effects similar to those of cocaine and methamphetamine.

CONCLUSIONS

All of the tested compounds produce discriminative stimulus effects similar to either those of cocaine, methamphetamine, or both, which suggests that these compounds are likely to have similar abuse liability to cocaine and/or methamphetamine. Pentylone may be more dangerous on the street, as it produced adverse effects at doses that produced maximal stimulant-like effects.

Authors+Show Affiliations

Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA, michael.gatch@unthsc.edu.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25281225

Citation

Gatch, Michael B., et al. "Discriminative and Locomotor Effects of Five Synthetic Cathinones in Rats and Mice." Psychopharmacology, vol. 232, no. 7, 2015, pp. 1197-205.
Gatch MB, Rutledge MA, Forster MJ. Discriminative and locomotor effects of five synthetic cathinones in rats and mice. Psychopharmacology (Berl). 2015;232(7):1197-205.
Gatch, M. B., Rutledge, M. A., & Forster, M. J. (2015). Discriminative and locomotor effects of five synthetic cathinones in rats and mice. Psychopharmacology, 232(7), 1197-205. https://doi.org/10.1007/s00213-014-3755-3
Gatch MB, Rutledge MA, Forster MJ. Discriminative and Locomotor Effects of Five Synthetic Cathinones in Rats and Mice. Psychopharmacology (Berl). 2015;232(7):1197-205. PubMed PMID: 25281225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative and locomotor effects of five synthetic cathinones in rats and mice. AU - Gatch,Michael B, AU - Rutledge,Margaret A, AU - Forster,Michael J, Y1 - 2014/10/05/ PY - 2014/08/01/received PY - 2014/09/20/accepted PY - 2014/10/5/entrez PY - 2014/10/5/pubmed PY - 2016/3/2/medline SP - 1197 EP - 205 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 232 IS - 7 N2 - RATIONALE: Synthetic cathinones continue to be sold as "legal" alternatives to methamphetamine or cocaine. As these marginally legal compounds become controlled, suppliers move to other, unregulated compounds. OBJECTIVES: The purpose of these experiments was to determine whether several temporarily controlled cathinone compounds, which are currently abused on the street, stimulate motor activity and have discriminative stimulus effects similar to cocaine and/or methamphetamine. METHODS: Methcathinone, pentedrone, pentylone, 3-fluoromethcathinone (3-FMC), and 4-methylethcathinone (4-MEC) were tested for locomotor stimulant effects in mice and subsequently for substitution in rats trained to discriminate cocaine (10 mg/kg, i.p.) or methamphetamine (1 mg/kg, i.p.) from saline. RESULTS: Methcathinone, pentedrone, and pentylone produced locomotor stimulant effects which lasted up to 6 h. In addition, pentylone produced convulsions and lethality at 100 mg/kg. 4-MEC produced locomotor stimulant effects which lasted up to 2 h. Methcathinone, pentedrone, pentylone, 3-FMC, and 4-MEC each produced discriminative stimulus effects similar to those of cocaine and methamphetamine. CONCLUSIONS: All of the tested compounds produce discriminative stimulus effects similar to either those of cocaine, methamphetamine, or both, which suggests that these compounds are likely to have similar abuse liability to cocaine and/or methamphetamine. Pentylone may be more dangerous on the street, as it produced adverse effects at doses that produced maximal stimulant-like effects. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/25281225/Discriminative_and_locomotor_effects_of_five_synthetic_cathinones_in_rats_and_mice_ L2 - https://dx.doi.org/10.1007/s00213-014-3755-3 DB - PRIME DP - Unbound Medicine ER -