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A prospective two-center study on the associations between microalbuminuria, coronary atherosclerosis and long-term clinical outcome in asymptomatic patients with type 2 diabetes mellitus: evaluation by coronary CT angiography.
Int J Cardiovasc Imaging. 2015 Jan; 31(1):193-203.IJ

Abstract

This study assessed the associations between microalbuminuria in asymptomatic patients with type 2 diabetes and the presence, extent, and severity of coronary atherosclerosis, as measured by coronary computed tomography angiography (CCTA), and the long-term clinical outcomes. In total, the study enrolled 284 consecutive eligible asymptomatic patients with type 2 diabetes and without known coronary artery disease (CAD), who then underwent CCTA and 24 h urine albumin measurements. Microalbuminuria was defined as 30-300 mg/day urinary albumin excretion. Obstructive CAD, as measured by CCTA, was defined as maximum intra-luminal stenosis ≥50 %. Patients with and without microalbuminuria were compared in terms of obstructive CAD prevalence, and the extent and severity of coronary atherosclerosis. They were evaluated using the following data: coronary artery calcium score (CACS), atheroma burden obstructive score (ABOS), segment involvement score (SIS) and segment stenosis score (SSS). All-cause mortality within a follow-up period of 5 years was also compared. Compared to patients without microalbuminuria, patients with microalbuminuria were more likely to have obstructive CAD (p = 0.004). Microalbuminuria was associated with higher ABOS (p = 0.010), SIS (p = 0.029), and SSS (p = 0.011), except for CACS (p = 0.058). Multivariable analyses adjusted for conventional cardiovascular risk factors revealed that microalbuminuria was an independent predictor of obstructive CAD [odds ratio 2.255, confidence intervals (CI) 1.121-4.538, p = 0.023] and all-cause mortality (hazard ratio 3.469, CI 1.319-9.121, p = 0.012). In asymptomatic patients with type 2 diabetes, microalbuminuria was associated with increased risk of CAD and poorer clinical outcomes.

Authors+Show Affiliations

Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, The Catholic University of Korea, Banpodong 505, Seochogu, Seoul, 137-701, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Observational Study

Language

eng

PubMed ID

25281423

Citation

Kim, Jin-Jin, et al. "A Prospective Two-center Study On the Associations Between Microalbuminuria, Coronary Atherosclerosis and Long-term Clinical Outcome in Asymptomatic Patients With Type 2 Diabetes Mellitus: Evaluation By Coronary CT Angiography." The International Journal of Cardiovascular Imaging, vol. 31, no. 1, 2015, pp. 193-203.
Kim JJ, Hwang BH, Choi IJ, et al. A prospective two-center study on the associations between microalbuminuria, coronary atherosclerosis and long-term clinical outcome in asymptomatic patients with type 2 diabetes mellitus: evaluation by coronary CT angiography. Int J Cardiovasc Imaging. 2015;31(1):193-203.
Kim, J. J., Hwang, B. H., Choi, I. J., Choo, E. H., Lim, S., Koh, Y. S., Lee, J. M., Kim, P. J., Seung, K. B., Lee, S. H., Cho, J. H., Jung, J. I., & Chang, K. (2015). A prospective two-center study on the associations between microalbuminuria, coronary atherosclerosis and long-term clinical outcome in asymptomatic patients with type 2 diabetes mellitus: evaluation by coronary CT angiography. The International Journal of Cardiovascular Imaging, 31(1), 193-203. https://doi.org/10.1007/s10554-014-0541-6
Kim JJ, et al. A Prospective Two-center Study On the Associations Between Microalbuminuria, Coronary Atherosclerosis and Long-term Clinical Outcome in Asymptomatic Patients With Type 2 Diabetes Mellitus: Evaluation By Coronary CT Angiography. Int J Cardiovasc Imaging. 2015;31(1):193-203. PubMed PMID: 25281423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective two-center study on the associations between microalbuminuria, coronary atherosclerosis and long-term clinical outcome in asymptomatic patients with type 2 diabetes mellitus: evaluation by coronary CT angiography. AU - Kim,Jin-Jin, AU - Hwang,Byung-Hee, AU - Choi,Ik Jun, AU - Choo,Eun-Ho, AU - Lim,Sungmin, AU - Koh,Yoon-Seok, AU - Lee,Jong Min, AU - Kim,Pum-Joon, AU - Seung,Ki-Bae, AU - Lee,Seung-Hwan, AU - Cho,Jae-Hyung, AU - Jung,Jung Im, AU - Chang,Kiyuk, Y1 - 2014/10/04/ PY - 2014/06/08/received PY - 2014/09/23/accepted PY - 2014/10/5/entrez PY - 2014/10/5/pubmed PY - 2015/9/22/medline SP - 193 EP - 203 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 31 IS - 1 N2 - This study assessed the associations between microalbuminuria in asymptomatic patients with type 2 diabetes and the presence, extent, and severity of coronary atherosclerosis, as measured by coronary computed tomography angiography (CCTA), and the long-term clinical outcomes. In total, the study enrolled 284 consecutive eligible asymptomatic patients with type 2 diabetes and without known coronary artery disease (CAD), who then underwent CCTA and 24 h urine albumin measurements. Microalbuminuria was defined as 30-300 mg/day urinary albumin excretion. Obstructive CAD, as measured by CCTA, was defined as maximum intra-luminal stenosis ≥50 %. Patients with and without microalbuminuria were compared in terms of obstructive CAD prevalence, and the extent and severity of coronary atherosclerosis. They were evaluated using the following data: coronary artery calcium score (CACS), atheroma burden obstructive score (ABOS), segment involvement score (SIS) and segment stenosis score (SSS). All-cause mortality within a follow-up period of 5 years was also compared. Compared to patients without microalbuminuria, patients with microalbuminuria were more likely to have obstructive CAD (p = 0.004). Microalbuminuria was associated with higher ABOS (p = 0.010), SIS (p = 0.029), and SSS (p = 0.011), except for CACS (p = 0.058). Multivariable analyses adjusted for conventional cardiovascular risk factors revealed that microalbuminuria was an independent predictor of obstructive CAD [odds ratio 2.255, confidence intervals (CI) 1.121-4.538, p = 0.023] and all-cause mortality (hazard ratio 3.469, CI 1.319-9.121, p = 0.012). In asymptomatic patients with type 2 diabetes, microalbuminuria was associated with increased risk of CAD and poorer clinical outcomes. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/25281423/A_prospective_two_center_study_on_the_associations_between_microalbuminuria_coronary_atherosclerosis_and_long_term_clinical_outcome_in_asymptomatic_patients_with_type_2_diabetes_mellitus:_evaluation_by_coronary_CT_angiography_ L2 - https://doi.org/10.1007/s10554-014-0541-6 DB - PRIME DP - Unbound Medicine ER -