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Lack of association between serum gamma-glutamyltransferase and carotid atherosclerosis: the Namwon Study.
Atherosclerosis 2014; 237(1):268-72A

Abstract

OBJECTIVES

There is little evidence for an association between gamma-glutamyltransferase (GGT) and carotid atherosclerosis, an independent predictor of cardiovascular disease. We examined the association between serum GGT and carotid atherosclerotic parameters, including carotid intima-media thickness (IMT) and plaques, in a large general population.

METHODS

The study population consisted of community-dwelling adults who participated in the baseline survey of the Namwon Study. A total of 9120 subjects aged 45-74 years were included in the analyses. High-resolution B-mode ultrasound was used to measure carotid IMT and to evaluate the presence of carotid plaques. A mean carotid IMT of ≥1.0 mm was classified as 'high carotid IMT'.

RESULTS

Serum GGT levels were classified into quartiles. In a fully adjusted model, we found no linear trend between GGT quartile and mean carotid IMT (P for trend = 0.167). Compared with the first quartile (the reference category), the odds ratios (ORs) and 95% confidence intervals (CIs) for high carotid IMT were 0.89 (0.68-1.16), 1.10 (0.84-1.43), and 0.97 (0.71-1.33) for the second, third, and fourth quartiles (P for trend = 0.754), respectively. The ORs (95% CIs) for carotid plaques were 0.89 (0.77-1.02), 0.95 (0.82-1.10), and 0.94 (0.79-1.11) for the second, third, and fourth quartiles, respectively, in the fully adjusted model (P for trend = 0.644).

CONCLUSIONS

No significant association of GGT concentration with carotid IMT or plaques was found in this large cross-sectional study. Further longitudinal studies are needed to confirm our findings.

Authors+Show Affiliations

Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Jeonbuk, South Korea; Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Jeonbuk, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.Department of Preventive Medicine, Chungnam National University College of Medicine, Daejeon, South Korea.Department of Neurology, Chonbuk National University Medical School-Chonbuk National University Hospital, Jeonju, Jeonbuk, South Korea.Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Jeonbuk, South Korea.Department of Preventive Medicine, Chosun University Medical School, Gwangju, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, South Korea. Electronic address: mhshinx@paran.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25282687

Citation

Lee, Young-Hoon, et al. "Lack of Association Between Serum Gamma-glutamyltransferase and Carotid Atherosclerosis: the Namwon Study." Atherosclerosis, vol. 237, no. 1, 2014, pp. 268-72.
Lee YH, Kweon SS, Choi JS, et al. Lack of association between serum gamma-glutamyltransferase and carotid atherosclerosis: the Namwon Study. Atherosclerosis. 2014;237(1):268-72.
Lee, Y. H., Kweon, S. S., Choi, J. S., Nam, H. S., Jeong, S. K., Park, K. S., ... Shin, M. H. (2014). Lack of association between serum gamma-glutamyltransferase and carotid atherosclerosis: the Namwon Study. Atherosclerosis, 237(1), pp. 268-72. doi:10.1016/j.atherosclerosis.2014.09.019.
Lee YH, et al. Lack of Association Between Serum Gamma-glutamyltransferase and Carotid Atherosclerosis: the Namwon Study. Atherosclerosis. 2014;237(1):268-72. PubMed PMID: 25282687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association between serum gamma-glutamyltransferase and carotid atherosclerosis: the Namwon Study. AU - Lee,Young-Hoon, AU - Kweon,Sun-Seog, AU - Choi,Jin-Su, AU - Nam,Hae-Sung, AU - Jeong,Seul-Ki, AU - Park,Kyeong-Soo, AU - Choi,Seong-Woo, AU - Ahn,Hye-Ran, AU - Shin,Min-Ho, Y1 - 2014/09/30/ PY - 2014/02/28/received PY - 2014/07/14/revised PY - 2014/09/09/accepted PY - 2014/10/6/entrez PY - 2014/10/6/pubmed PY - 2015/8/19/medline KW - Atherosclerosis KW - Carotid intima-media thickness KW - Gamma-glutamyltransferase KW - Plaque SP - 268 EP - 72 JF - Atherosclerosis JO - Atherosclerosis VL - 237 IS - 1 N2 - OBJECTIVES: There is little evidence for an association between gamma-glutamyltransferase (GGT) and carotid atherosclerosis, an independent predictor of cardiovascular disease. We examined the association between serum GGT and carotid atherosclerotic parameters, including carotid intima-media thickness (IMT) and plaques, in a large general population. METHODS: The study population consisted of community-dwelling adults who participated in the baseline survey of the Namwon Study. A total of 9120 subjects aged 45-74 years were included in the analyses. High-resolution B-mode ultrasound was used to measure carotid IMT and to evaluate the presence of carotid plaques. A mean carotid IMT of ≥1.0 mm was classified as 'high carotid IMT'. RESULTS: Serum GGT levels were classified into quartiles. In a fully adjusted model, we found no linear trend between GGT quartile and mean carotid IMT (P for trend = 0.167). Compared with the first quartile (the reference category), the odds ratios (ORs) and 95% confidence intervals (CIs) for high carotid IMT were 0.89 (0.68-1.16), 1.10 (0.84-1.43), and 0.97 (0.71-1.33) for the second, third, and fourth quartiles (P for trend = 0.754), respectively. The ORs (95% CIs) for carotid plaques were 0.89 (0.77-1.02), 0.95 (0.82-1.10), and 0.94 (0.79-1.11) for the second, third, and fourth quartiles, respectively, in the fully adjusted model (P for trend = 0.644). CONCLUSIONS: No significant association of GGT concentration with carotid IMT or plaques was found in this large cross-sectional study. Further longitudinal studies are needed to confirm our findings. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/25282687/Lack_of_association_between_serum_gamma_glutamyltransferase_and_carotid_atherosclerosis:_the_Namwon_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(14)01421-X DB - PRIME DP - Unbound Medicine ER -