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Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial.
Acta Paediatr. 2015 Apr; 104(4):396-404.AP

Abstract

AIM

To determine whether vitamin D supplementation reduces primary care visits for acute respiratory infection (ARI).

METHODS

A randomised, double-blind, placebo-controlled trial was conducted in New Zealand and powered to determine the vitamin D dose needed to achieve normal vitamin D status during infancy. Healthy pregnant women, from 27 weeks' gestation to birth, and their infants, from birth to age 6 months, were assigned to placebo or one of the two dosages of daily oral vitamin D3 . Woman/infant pairs were randomised to placebo/placebo, 1000 IU/400 IU or 2000 IU/800 IU. For this ad hoc analysis, the primary care records of enrolled children were audited to age 18 months.

RESULTS

Two hundred and sixty pregnant women were randomised to placebo (n = 87), lower-dose (n = 87) or higher-dose (n = 86) vitamin D3 . In comparison with the placebo group (99%), the proportion of children making any ARI visits was smaller in the higher-dose (87%, p = 0.004), but not the lower-dose vitamin D3 group (95%, p = 0.17). The median number of ARI visits/child was less in the higher-dose vitamin D3 group from age 6-18 months (placebo 4, lower dose 3, higher dose 2.5; p = 0.048 for higher-dose vitamin D3 vs. placebo).

CONCLUSION

Vitamin D3 supplementation during pregnancy and infancy reduces primary care visits for ARI during early childhood.

Authors+Show Affiliations

Department of Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25283480

Citation

Grant, Cameron C., et al. "Reduced Primary Care Respiratory Infection Visits Following Pregnancy and Infancy Vitamin D Supplementation: a Randomised Controlled Trial." Acta Paediatrica (Oslo, Norway : 1992), vol. 104, no. 4, 2015, pp. 396-404.
Grant CC, Kaur S, Waymouth E, et al. Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial. Acta Paediatr. 2015;104(4):396-404.
Grant, C. C., Kaur, S., Waymouth, E., Mitchell, E. A., Scragg, R., Ekeroma, A., Stewart, A., Crane, J., Trenholme, A., & Camargo, C. A. (2015). Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial. Acta Paediatrica (Oslo, Norway : 1992), 104(4), 396-404. https://doi.org/10.1111/apa.12819
Grant CC, et al. Reduced Primary Care Respiratory Infection Visits Following Pregnancy and Infancy Vitamin D Supplementation: a Randomised Controlled Trial. Acta Paediatr. 2015;104(4):396-404. PubMed PMID: 25283480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial. AU - Grant,Cameron C, AU - Kaur,Suhina, AU - Waymouth,Ellen, AU - Mitchell,Edwin A, AU - Scragg,Robert, AU - Ekeroma,Alec, AU - Stewart,Alistair, AU - Crane,Julian, AU - Trenholme,Adrian, AU - Camargo,Carlos A,Jr Y1 - 2014/10/21/ PY - 2014/06/24/received PY - 2014/09/16/revised PY - 2014/09/29/accepted PY - 2014/10/7/entrez PY - 2014/10/7/pubmed PY - 2015/12/29/medline KW - Child KW - Clinical trial KW - Pregnancy KW - Respiratory tract infections KW - Vitamin D SP - 396 EP - 404 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 104 IS - 4 N2 - AIM: To determine whether vitamin D supplementation reduces primary care visits for acute respiratory infection (ARI). METHODS: A randomised, double-blind, placebo-controlled trial was conducted in New Zealand and powered to determine the vitamin D dose needed to achieve normal vitamin D status during infancy. Healthy pregnant women, from 27 weeks' gestation to birth, and their infants, from birth to age 6 months, were assigned to placebo or one of the two dosages of daily oral vitamin D3 . Woman/infant pairs were randomised to placebo/placebo, 1000 IU/400 IU or 2000 IU/800 IU. For this ad hoc analysis, the primary care records of enrolled children were audited to age 18 months. RESULTS: Two hundred and sixty pregnant women were randomised to placebo (n = 87), lower-dose (n = 87) or higher-dose (n = 86) vitamin D3 . In comparison with the placebo group (99%), the proportion of children making any ARI visits was smaller in the higher-dose (87%, p = 0.004), but not the lower-dose vitamin D3 group (95%, p = 0.17). The median number of ARI visits/child was less in the higher-dose vitamin D3 group from age 6-18 months (placebo 4, lower dose 3, higher dose 2.5; p = 0.048 for higher-dose vitamin D3 vs. placebo). CONCLUSION: Vitamin D3 supplementation during pregnancy and infancy reduces primary care visits for ARI during early childhood. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/25283480/Reduced_primary_care_respiratory_infection_visits_following_pregnancy_and_infancy_vitamin_D_supplementation:_a_randomised_controlled_trial_ L2 - https://doi.org/10.1111/apa.12819 DB - PRIME DP - Unbound Medicine ER -