Tags

Type your tag names separated by a space and hit enter

Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study.
Int J Cancer. 2015 May 01; 136(9):2178-86.IJ

Abstract

Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated with breast cancer risk. Data was used from women participating in the Rotterdam Study, a prospective cohort study among subjects aged 55 years and older (N = 3,209). FRAP scores and antioxidant intake (i.e., vitamin A, C, E, selenium, flavonoids and carotenoids) was assessed at baseline by a food frequency questionnaire. Incident cases of breast cancer were confirmed through medical reports. During a median follow-up of 17 years, 199 cases with breast cancer were identified. High dietary FRAP score was associated with a lower risk of breast cancer [hazard ratio (HR): 0.68; 95% confidence intervals (CI): 0.49, 0.96]. No overall association between individual antioxidant intake and breast cancer risk was found. However, low intake of alpha carotene and beta carotene was associated with a higher risk of breast cancer among smokers (HR: 2.48; 95% CI: 1.21, 5.12 and HR: 2.31; 95% CI: 1.12, 4.76 for alpha and beta carotene, respectively) and low intake of flavonoids was associated with breast cancer risk in women over the age of 70 (HR: 1.80; 95% CI: 1.09, 2.99). These results suggest that high overall dietary antioxidant capacity is associated with a lower risk of breast cancer. Individual effects of dietary carotenoids and dietary flavonoids may be restricted to subgroups such as smokers and elderly.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Pantavos A
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Ruiter R
No affiliation info available
Feskens EF
No affiliation info available
de Keyser CE
No affiliation info available
Hofman A
No affiliation info available
Stricker BH
No affiliation info available
Franco OH
No affiliation info available
Kiefte-de Jong JC
No affiliation info available

MeSH

AdultAgedAntioxidantsBreast NeoplasmsCarotenoidsDietDietary SupplementsFemaleFlavonoidsHumansMiddle AgedProspective StudiesRiskbeta Carotene

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25284450

Citation

Pantavos, Athanasios, et al. "Total Dietary Antioxidant Capacity, Individual Antioxidant Intake and Breast Cancer Risk: the Rotterdam Study." International Journal of Cancer, vol. 136, no. 9, 2015, pp. 2178-86.
Pantavos A, Ruiter R, Feskens EF, et al. Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study. Int J Cancer. 2015;136(9):2178-86.
Pantavos, A., Ruiter, R., Feskens, E. F., de Keyser, C. E., Hofman, A., Stricker, B. H., Franco, O. H., & Kiefte-de Jong, J. C. (2015). Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study. International Journal of Cancer, 136(9), 2178-86. https://doi.org/10.1002/ijc.29249
Pantavos A, et al. Total Dietary Antioxidant Capacity, Individual Antioxidant Intake and Breast Cancer Risk: the Rotterdam Study. Int J Cancer. 2015 May 1;136(9):2178-86. PubMed PMID: 25284450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study. AU - Pantavos,Athanasios, AU - Ruiter,Rikje, AU - Feskens,Edith F, AU - de Keyser,Catherine E, AU - Hofman,Albert, AU - Stricker,Bruno H, AU - Franco,Oscar H, AU - Kiefte-de Jong,Jessica C, Y1 - 2014/10/18/ PY - 2014/05/06/received PY - 2014/08/26/revised PY - 2014/09/12/accepted PY - 2014/10/7/entrez PY - 2014/10/7/pubmed PY - 2015/4/17/medline KW - FRAP KW - antioxidants KW - breast cancer KW - nutrition SP - 2178 EP - 86 JF - International journal of cancer JO - Int J Cancer VL - 136 IS - 9 N2 - Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated with breast cancer risk. Data was used from women participating in the Rotterdam Study, a prospective cohort study among subjects aged 55 years and older (N = 3,209). FRAP scores and antioxidant intake (i.e., vitamin A, C, E, selenium, flavonoids and carotenoids) was assessed at baseline by a food frequency questionnaire. Incident cases of breast cancer were confirmed through medical reports. During a median follow-up of 17 years, 199 cases with breast cancer were identified. High dietary FRAP score was associated with a lower risk of breast cancer [hazard ratio (HR): 0.68; 95% confidence intervals (CI): 0.49, 0.96]. No overall association between individual antioxidant intake and breast cancer risk was found. However, low intake of alpha carotene and beta carotene was associated with a higher risk of breast cancer among smokers (HR: 2.48; 95% CI: 1.21, 5.12 and HR: 2.31; 95% CI: 1.12, 4.76 for alpha and beta carotene, respectively) and low intake of flavonoids was associated with breast cancer risk in women over the age of 70 (HR: 1.80; 95% CI: 1.09, 2.99). These results suggest that high overall dietary antioxidant capacity is associated with a lower risk of breast cancer. Individual effects of dietary carotenoids and dietary flavonoids may be restricted to subgroups such as smokers and elderly. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/25284450/Total_dietary_antioxidant_capacity_individual_antioxidant_intake_and_breast_cancer_risk:_the_Rotterdam_Study_ DB - PRIME DP - Unbound Medicine ER -