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Meaning of visualizing retinal cone mosaic on adaptive optics images.
Am J Ophthalmol 2015; 159(1):118-23.e1AJ

Abstract

PURPOSE

To explore the anatomic correlation of the retinal cone mosaic on adaptive optics images.

DESIGN

Retrospective nonconsecutive observational case series.

METHODS

A retrospective review of the multimodal imaging charts of 6 patients with focal alteration of the cone mosaic on adaptive optics was performed. Retinal diseases included acute posterior multifocal placoid pigment epitheliopathy (n = 1), hydroxychloroquine retinopathy (n = 1), and macular telangiectasia type 2 (n = 4). High-resolution retinal images were obtained using a flood-illumination adaptive optics camera. Images were recorded using standard imaging modalities: color and red-free fundus camera photography; infrared reflectance scanning laser ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography (OCT) images.

RESULTS

On OCT, in the marginal zone of the lesions, a disappearance of the interdigitation zone was observed, while the ellipsoid zone was preserved. Image recording demonstrated that such attenuation of the interdigitation zone co-localized with the disappearance of the cone mosaic on adaptive optics images. In 1 case, the restoration of the interdigitation zone paralleled that of the cone mosaic after a 2-month follow-up.

CONCLUSION

Our results suggest that the interdigitation zone could contribute substantially to the reflectance of the cone photoreceptor mosaic. The absence of cones on adaptive optics images does not necessarily mean photoreceptor cell death.

Authors+Show Affiliations

Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.Clinical Investigation Center 1423, Centre Hospitalier National des Quinze-Vingts, Institut National de la santé et de la recherche médicale & Université Pierre et Marie Curie, Paris, France.Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.Institut d'Optique Graduate School - Centre National de la Recherche Scientifique - Université Paris 11, Palaiseau, France.Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. Electronic address: agaudric@gmail.com.

Pub Type(s)

Case Reports
Journal Article
Observational Study

Language

eng

PubMed ID

25284764

Citation

Jacob, Julie, et al. "Meaning of Visualizing Retinal Cone Mosaic On Adaptive Optics Images." American Journal of Ophthalmology, vol. 159, no. 1, 2015, pp. 118-23.e1.
Jacob J, Paques M, Krivosic V, et al. Meaning of visualizing retinal cone mosaic on adaptive optics images. Am J Ophthalmol. 2015;159(1):118-23.e1.
Jacob, J., Paques, M., Krivosic, V., Dupas, B., Couturier, A., Kulcsar, C., ... Gaudric, A. (2015). Meaning of visualizing retinal cone mosaic on adaptive optics images. American Journal of Ophthalmology, 159(1), pp. 118-23.e1. doi:10.1016/j.ajo.2014.09.043.
Jacob J, et al. Meaning of Visualizing Retinal Cone Mosaic On Adaptive Optics Images. Am J Ophthalmol. 2015;159(1):118-23.e1. PubMed PMID: 25284764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meaning of visualizing retinal cone mosaic on adaptive optics images. AU - Jacob,Julie, AU - Paques,Michel, AU - Krivosic,Valérie, AU - Dupas,Bénédicte, AU - Couturier,Aude, AU - Kulcsar,Caroline, AU - Tadayoni,Ramin, AU - Massin,Pascale, AU - Gaudric,Alain, Y1 - 2014/10/02/ PY - 2014/05/09/received PY - 2014/09/29/revised PY - 2014/09/30/accepted PY - 2014/10/7/entrez PY - 2014/10/7/pubmed PY - 2015/2/3/medline SP - 118 EP - 23.e1 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 159 IS - 1 N2 - PURPOSE: To explore the anatomic correlation of the retinal cone mosaic on adaptive optics images. DESIGN: Retrospective nonconsecutive observational case series. METHODS: A retrospective review of the multimodal imaging charts of 6 patients with focal alteration of the cone mosaic on adaptive optics was performed. Retinal diseases included acute posterior multifocal placoid pigment epitheliopathy (n = 1), hydroxychloroquine retinopathy (n = 1), and macular telangiectasia type 2 (n = 4). High-resolution retinal images were obtained using a flood-illumination adaptive optics camera. Images were recorded using standard imaging modalities: color and red-free fundus camera photography; infrared reflectance scanning laser ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography (OCT) images. RESULTS: On OCT, in the marginal zone of the lesions, a disappearance of the interdigitation zone was observed, while the ellipsoid zone was preserved. Image recording demonstrated that such attenuation of the interdigitation zone co-localized with the disappearance of the cone mosaic on adaptive optics images. In 1 case, the restoration of the interdigitation zone paralleled that of the cone mosaic after a 2-month follow-up. CONCLUSION: Our results suggest that the interdigitation zone could contribute substantially to the reflectance of the cone photoreceptor mosaic. The absence of cones on adaptive optics images does not necessarily mean photoreceptor cell death. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/25284764/Meaning_of_visualizing_retinal_cone_mosaic_on_adaptive_optics_images_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(14)00633-3 DB - PRIME DP - Unbound Medicine ER -