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Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors.
Psychoneuroendocrinology. 2015 Jan; 51:68-79.P

Abstract

The role of norepinephrine (NE) in the consolidation of inhibitory avoidance learning (IA) in rats is known to involve α1- and β-adrenoceptor systems in the basolateral nucleus of the amygdala (BLA). However, the amygdala also contains α2-adrenoceptor subtypes, and local microinfusions of the selective α2-adrenoceptor antagonist idazoxan and agonist UK 14,304 respectively into the BLA enhance and inhibit IA performances when administered before acquisition. The present study investigated whether the effects of idazoxan and UK 14,304 on IA were associated with changes in NE release within the BLA before and after one-trial inhibitory avoidance training. Male Sprague-Dawley rats were unilaterally implanted with a microdialysis probe in the BLA and were administered idazoxan (0.1mM) or UK 14,304 (10 μM) by retrodialysis infusion 15 min before the acquisition of IA. Dialysates were collected every 15 min for analysis of NE. Retrodialysis of idazoxan potentiated the release of NE induced by footshock application, whereas UK 14,304 decreased NE release to the extent that the footshock failed to induce any measurable effect on NE levels. Idazoxan infusion enhanced IA retention tested 24h later and this effect was directly related to the level of NE release in the BLA measured during IA acquisition. In contrast, the infusion of UK 14,304 did not modify IA performances in comparison to control animals, possibly due to compensatory activity of the contralateral BLA. These results are consistent with previous evidence that amygdala NE is involved in modulating memory consolidation, and provide evidence for an involvement of presynaptic α2-autoceptors in the BLA in this process.

Authors+Show Affiliations

INSERM, U1028; CNRS, UMR5292; Université Lyon 1; Lyon Neuroscience Research Center, 50 avenue Tony Garnier, F-69366 Lyon France. Electronic address: bferry@olfac.univ-lyon1.fr.INSERM, U1028; CNRS, UMR5292; Université Lyon 1; Lyon Neuroscience Research Center, 50 avenue Tony Garnier, F-69366 Lyon France; INSERM, U1028; Université Lyon 1; UMR 5292 CNRS; Lyon Neuroscience Research Center, NeuroDialyTics, 8 Avenue Rockefeller, F-69373 Lyon Cedex 08 France.Institut de Recherche Pierre Fabre, Castres 81106, France.Laboratoire de Neurosciences Cognitives et Adaptatives, UMR 7364 Université de Strasbourg-CNRS, Faculté de Psychologie, Neuropôle de Strasbourg, 12 rue Goethe, F-67000 Strasbourg, France.Laboratoire de Neurosciences Cognitives et Adaptatives, UMR 7364 Université de Strasbourg-CNRS, Faculté de Psychologie, Neuropôle de Strasbourg, 12 rue Goethe, F-67000 Strasbourg, France.Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California Irvine, CA 92697-3800, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25286225

Citation

Ferry, Barbara, et al. "Noradrenergic Influences in the Basolateral Amygdala On Inhibitory Avoidance Memory Are Mediated By an Action On Α2-adrenoceptors." Psychoneuroendocrinology, vol. 51, 2015, pp. 68-79.
Ferry B, Parrot S, Marien M, et al. Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors. Psychoneuroendocrinology. 2015;51:68-79.
Ferry, B., Parrot, S., Marien, M., Lazarus, C., Cassel, J. C., & McGaugh, J. L. (2015). Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors. Psychoneuroendocrinology, 51, 68-79. https://doi.org/10.1016/j.psyneuen.2014.09.010
Ferry B, et al. Noradrenergic Influences in the Basolateral Amygdala On Inhibitory Avoidance Memory Are Mediated By an Action On Α2-adrenoceptors. Psychoneuroendocrinology. 2015;51:68-79. PubMed PMID: 25286225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors. AU - Ferry,Barbara, AU - Parrot,Sandrine, AU - Marien,Marc, AU - Lazarus,Christine, AU - Cassel,Jean-Christophe, AU - McGaugh,James L, Y1 - 2014/09/19/ PY - 2014/06/13/received PY - 2014/09/08/revised PY - 2014/09/10/accepted PY - 2014/10/7/entrez PY - 2014/10/7/pubmed PY - 2015/8/22/medline KW - Basolateral amygdala KW - Inhibitory avoidance learning KW - Memory modulation KW - Norepinephrine KW - Retrodialysis KW - α(2)-Adrenoceptor SP - 68 EP - 79 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 51 N2 - The role of norepinephrine (NE) in the consolidation of inhibitory avoidance learning (IA) in rats is known to involve α1- and β-adrenoceptor systems in the basolateral nucleus of the amygdala (BLA). However, the amygdala also contains α2-adrenoceptor subtypes, and local microinfusions of the selective α2-adrenoceptor antagonist idazoxan and agonist UK 14,304 respectively into the BLA enhance and inhibit IA performances when administered before acquisition. The present study investigated whether the effects of idazoxan and UK 14,304 on IA were associated with changes in NE release within the BLA before and after one-trial inhibitory avoidance training. Male Sprague-Dawley rats were unilaterally implanted with a microdialysis probe in the BLA and were administered idazoxan (0.1mM) or UK 14,304 (10 μM) by retrodialysis infusion 15 min before the acquisition of IA. Dialysates were collected every 15 min for analysis of NE. Retrodialysis of idazoxan potentiated the release of NE induced by footshock application, whereas UK 14,304 decreased NE release to the extent that the footshock failed to induce any measurable effect on NE levels. Idazoxan infusion enhanced IA retention tested 24h later and this effect was directly related to the level of NE release in the BLA measured during IA acquisition. In contrast, the infusion of UK 14,304 did not modify IA performances in comparison to control animals, possibly due to compensatory activity of the contralateral BLA. These results are consistent with previous evidence that amygdala NE is involved in modulating memory consolidation, and provide evidence for an involvement of presynaptic α2-autoceptors in the BLA in this process. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/25286225/Noradrenergic_influences_in_the_basolateral_amygdala_on_inhibitory_avoidance_memory_are_mediated_by_an_action_on_α2_adrenoceptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(14)00350-3 DB - PRIME DP - Unbound Medicine ER -