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Editorial: The importance of systematic reviews and meta-analyses of probiotics and prebiotics.
Am J Gastroenterol 2014; 109(10):1563-5AJ

Abstract

Irritable bowel syndrome (IBS) and chronic idiopathic constipation are prevalent and burdensome gastrointestinal disorders. A systematic review and meta-analysis of the evidence for probiotics, prebiotics, and synbiotics in IBS and chronic idiopathic constipation has recently been performed. By far, the most convincing evidence was for the use of probiotics in IBS, which reported that overall probiotics reduced the risk of symptom persistence by 21%. However, only a minority of the trials were at a low risk of bias, and some used small sample sizes. Meta-analysis is a powerful tool to combine individual small trials to improve the power to detect the direction, size, and consistency of an effect, but it can do little to overcome the poor design of individual trials. Many debate the use of meta-analysis to combine data from different probiotic species, strains, or combinations. It is recommended that all future meta-analyses of probiotics, in any clinical setting, perform subgroup analysis on specific species/strains and specific combinations. It is hoped that the current meta-analysis will empower clinicians in making evidence-based decisions regarding whether probiotics should be recommended for IBS, which species/strain(s) to use, and for which symptoms.

Authors+Show Affiliations

King's College London, Diabetes and Nutritional Sciences Division, School of Medicine, London, UK.

Pub Type(s)

Editorial
Comment

Language

eng

PubMed ID

25287086

Citation

Whelan, Kevin. "Editorial: the Importance of Systematic Reviews and Meta-analyses of Probiotics and Prebiotics." The American Journal of Gastroenterology, vol. 109, no. 10, 2014, pp. 1563-5.
Whelan K. Editorial: The importance of systematic reviews and meta-analyses of probiotics and prebiotics. Am J Gastroenterol. 2014;109(10):1563-5.
Whelan, K. (2014). Editorial: The importance of systematic reviews and meta-analyses of probiotics and prebiotics. The American Journal of Gastroenterology, 109(10), pp. 1563-5. doi:10.1038/ajg.2014.258.
Whelan K. Editorial: the Importance of Systematic Reviews and Meta-analyses of Probiotics and Prebiotics. Am J Gastroenterol. 2014;109(10):1563-5. PubMed PMID: 25287086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Editorial: The importance of systematic reviews and meta-analyses of probiotics and prebiotics. A1 - Whelan,Kevin, PY - 2014/10/8/entrez PY - 2014/10/8/pubmed PY - 2015/2/24/medline SP - 1563 EP - 5 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 109 IS - 10 N2 - Irritable bowel syndrome (IBS) and chronic idiopathic constipation are prevalent and burdensome gastrointestinal disorders. A systematic review and meta-analysis of the evidence for probiotics, prebiotics, and synbiotics in IBS and chronic idiopathic constipation has recently been performed. By far, the most convincing evidence was for the use of probiotics in IBS, which reported that overall probiotics reduced the risk of symptom persistence by 21%. However, only a minority of the trials were at a low risk of bias, and some used small sample sizes. Meta-analysis is a powerful tool to combine individual small trials to improve the power to detect the direction, size, and consistency of an effect, but it can do little to overcome the poor design of individual trials. Many debate the use of meta-analysis to combine data from different probiotic species, strains, or combinations. It is recommended that all future meta-analyses of probiotics, in any clinical setting, perform subgroup analysis on specific species/strains and specific combinations. It is hoped that the current meta-analysis will empower clinicians in making evidence-based decisions regarding whether probiotics should be recommended for IBS, which species/strain(s) to use, and for which symptoms. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/25287086/Editorial:_The_importance_of_systematic_reviews_and_meta_analyses_of_probiotics_and_prebiotics_ L2 - http://Insights.ovid.com/pubmed?pmid=25287086 DB - PRIME DP - Unbound Medicine ER -