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Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study.

Abstract

The role of oxidative stress in skeletal health is unclear. The present study investigated whether a high dietary intake of antioxidant nutrients (vitamins C and E, β-carotene, animal-derived vitamin A, retinol equivalents, Zn and Se) is associated with a reduced risk of hip fracture in elderly Chinese. This 1:1 matched case-control study involved 726 elderly Chinese with hip fracture and 726 control subjects, recruited between June 2009 and May 2013. Face-to-face interviews were conducted to determine habitual dietary intakes of the above-mentioned seven nutrients based on a seventy-nine-item FFQ and information on various covariates, and an antioxidant score was calculated. After adjustment for potential covariates, dose-dependent inverse associations were observed between the dietary intake of vitamin C, vitamin E, β-carotene, and Se and antioxidant score and the risk of hip fracture (P for trend ≤ 0·005). The OR of hip fracture for the highest (v. lowest) quartile of intake were 0·39 (95 % CI 0·28, 0·56) for vitamin C, 0·23 (95 % CI 0·16, 0·33) for vitamin E, 0·51 (95 % CI 0·36, 0·73) for β-carotene, 0·43 (95 % CI 0·26, 0·70) for Se and 0·24 (95 % CI 0·17, 0·36) for the antioxidant score. A moderate-to-high dietary intake of retinol equivalents in quartiles 2-4 (v. 1) was found to be associated with a lower risk of hip fracture (OR range: 0·51-0·63, P< 0·05). No significant association was observed between dietary Zn or animal-derived vitamin A intake and hip fracture risk (P for trend >0·20). In conclusion, a higher dietary intake of vitamins C and E, β-carotene, and Se and a moderate-to-high dietary intake of retinol equivalents are associated with a lower risk of hip fracture in elderly Chinese.

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  • Authors+Show Affiliations

    ,

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

    ,

    Guangzhou Orthopaedics Trauma Hospital,Guangzhou510045,People's Republic of China.

    ,

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

    ,

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

    ,

    Guangzhou Orthopaedics Trauma Hospital,Guangzhou510045,People's Republic of China.

    ,

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

    ,

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

    Source

    The British journal of nutrition 112:10 2014 Nov 28 pg 1706-14

    MeSH

    Aged
    Antioxidants
    Ascorbic Acid
    Asian Continental Ancestry Group
    Case-Control Studies
    China
    Female
    Hip Fractures
    Humans
    Middle Aged
    Odds Ratio
    Osteoporosis
    Oxidative Stress
    Risk
    Risk Factors
    Selenium
    Trace Elements
    Vitamin A
    Vitamin E
    Vitamins
    Zinc
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25287150

    Citation

    Sun, Li-li, et al. "Associations Between the Dietary Intake of Antioxidant Nutrients and the Risk of Hip Fracture in Elderly Chinese: a Case-control Study." The British Journal of Nutrition, vol. 112, no. 10, 2014, pp. 1706-14.
    Sun LL, Li BL, Xie HL, et al. Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study. Br J Nutr. 2014;112(10):1706-14.
    Sun, L. L., Li, B. L., Xie, H. L., Fan, F., Yu, W. Z., Wu, B. H., ... Chen, Y. M. (2014). Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study. The British Journal of Nutrition, 112(10), pp. 1706-14. doi:10.1017/S0007114514002773.
    Sun LL, et al. Associations Between the Dietary Intake of Antioxidant Nutrients and the Risk of Hip Fracture in Elderly Chinese: a Case-control Study. Br J Nutr. 2014 Nov 28;112(10):1706-14. PubMed PMID: 25287150.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study. AU - Sun,Li-li, AU - Li,Bao-lin, AU - Xie,Hai-li, AU - Fan,Fan, AU - Yu,Wei-zhong, AU - Wu,Bao-hua, AU - Xue,Wen-qiong, AU - Chen,Yu-ming, Y1 - 2014/10/07/ PY - 2014/10/8/entrez PY - 2014/10/8/pubmed PY - 2015/1/13/medline SP - 1706 EP - 14 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 112 IS - 10 N2 - The role of oxidative stress in skeletal health is unclear. The present study investigated whether a high dietary intake of antioxidant nutrients (vitamins C and E, β-carotene, animal-derived vitamin A, retinol equivalents, Zn and Se) is associated with a reduced risk of hip fracture in elderly Chinese. This 1:1 matched case-control study involved 726 elderly Chinese with hip fracture and 726 control subjects, recruited between June 2009 and May 2013. Face-to-face interviews were conducted to determine habitual dietary intakes of the above-mentioned seven nutrients based on a seventy-nine-item FFQ and information on various covariates, and an antioxidant score was calculated. After adjustment for potential covariates, dose-dependent inverse associations were observed between the dietary intake of vitamin C, vitamin E, β-carotene, and Se and antioxidant score and the risk of hip fracture (P for trend ≤ 0·005). The OR of hip fracture for the highest (v. lowest) quartile of intake were 0·39 (95 % CI 0·28, 0·56) for vitamin C, 0·23 (95 % CI 0·16, 0·33) for vitamin E, 0·51 (95 % CI 0·36, 0·73) for β-carotene, 0·43 (95 % CI 0·26, 0·70) for Se and 0·24 (95 % CI 0·17, 0·36) for the antioxidant score. A moderate-to-high dietary intake of retinol equivalents in quartiles 2-4 (v. 1) was found to be associated with a lower risk of hip fracture (OR range: 0·51-0·63, P< 0·05). No significant association was observed between dietary Zn or animal-derived vitamin A intake and hip fracture risk (P for trend >0·20). In conclusion, a higher dietary intake of vitamins C and E, β-carotene, and Se and a moderate-to-high dietary intake of retinol equivalents are associated with a lower risk of hip fracture in elderly Chinese. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25287150/Associations_between_the_dietary_intake_of_antioxidant_nutrients_and_the_risk_of_hip_fracture_in_elderly_Chinese:_a_case_control_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114514002773/type/journal_article DB - PRIME DP - Unbound Medicine ER -