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Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study.
Br J Nutr 2014; 112(10):1706-14BJ

Abstract

The role of oxidative stress in skeletal health is unclear. The present study investigated whether a high dietary intake of antioxidant nutrients (vitamins C and E, β-carotene, animal-derived vitamin A, retinol equivalents, Zn and Se) is associated with a reduced risk of hip fracture in elderly Chinese. This 1:1 matched case-control study involved 726 elderly Chinese with hip fracture and 726 control subjects, recruited between June 2009 and May 2013. Face-to-face interviews were conducted to determine habitual dietary intakes of the above-mentioned seven nutrients based on a seventy-nine-item FFQ and information on various covariates, and an antioxidant score was calculated. After adjustment for potential covariates, dose-dependent inverse associations were observed between the dietary intake of vitamin C, vitamin E, β-carotene, and Se and antioxidant score and the risk of hip fracture (P for trend ≤ 0·005). The OR of hip fracture for the highest (v. lowest) quartile of intake were 0·39 (95 % CI 0·28, 0·56) for vitamin C, 0·23 (95 % CI 0·16, 0·33) for vitamin E, 0·51 (95 % CI 0·36, 0·73) for β-carotene, 0·43 (95 % CI 0·26, 0·70) for Se and 0·24 (95 % CI 0·17, 0·36) for the antioxidant score. A moderate-to-high dietary intake of retinol equivalents in quartiles 2-4 (v. 1) was found to be associated with a lower risk of hip fracture (OR range: 0·51-0·63, P< 0·05). No significant association was observed between dietary Zn or animal-derived vitamin A intake and hip fracture risk (P for trend >0·20). In conclusion, a higher dietary intake of vitamins C and E, β-carotene, and Se and a moderate-to-high dietary intake of retinol equivalents are associated with a lower risk of hip fracture in elderly Chinese.

Authors+Show Affiliations

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.Guangzhou Orthopaedics Trauma Hospital,Guangzhou510045,People's Republic of China.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.Guangzhou Orthopaedics Trauma Hospital,Guangzhou510045,People's Republic of China.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25287150

Citation

Sun, Li-li, et al. "Associations Between the Dietary Intake of Antioxidant Nutrients and the Risk of Hip Fracture in Elderly Chinese: a Case-control Study." The British Journal of Nutrition, vol. 112, no. 10, 2014, pp. 1706-14.
Sun LL, Li BL, Xie HL, et al. Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study. Br J Nutr. 2014;112(10):1706-14.
Sun, L. L., Li, B. L., Xie, H. L., Fan, F., Yu, W. Z., Wu, B. H., ... Chen, Y. M. (2014). Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study. The British Journal of Nutrition, 112(10), pp. 1706-14. doi:10.1017/S0007114514002773.
Sun LL, et al. Associations Between the Dietary Intake of Antioxidant Nutrients and the Risk of Hip Fracture in Elderly Chinese: a Case-control Study. Br J Nutr. 2014 Nov 28;112(10):1706-14. PubMed PMID: 25287150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study. AU - Sun,Li-li, AU - Li,Bao-lin, AU - Xie,Hai-li, AU - Fan,Fan, AU - Yu,Wei-zhong, AU - Wu,Bao-hua, AU - Xue,Wen-qiong, AU - Chen,Yu-ming, Y1 - 2014/10/07/ PY - 2014/10/8/entrez PY - 2014/10/8/pubmed PY - 2015/1/13/medline SP - 1706 EP - 14 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 112 IS - 10 N2 - The role of oxidative stress in skeletal health is unclear. The present study investigated whether a high dietary intake of antioxidant nutrients (vitamins C and E, β-carotene, animal-derived vitamin A, retinol equivalents, Zn and Se) is associated with a reduced risk of hip fracture in elderly Chinese. This 1:1 matched case-control study involved 726 elderly Chinese with hip fracture and 726 control subjects, recruited between June 2009 and May 2013. Face-to-face interviews were conducted to determine habitual dietary intakes of the above-mentioned seven nutrients based on a seventy-nine-item FFQ and information on various covariates, and an antioxidant score was calculated. After adjustment for potential covariates, dose-dependent inverse associations were observed between the dietary intake of vitamin C, vitamin E, β-carotene, and Se and antioxidant score and the risk of hip fracture (P for trend ≤ 0·005). The OR of hip fracture for the highest (v. lowest) quartile of intake were 0·39 (95 % CI 0·28, 0·56) for vitamin C, 0·23 (95 % CI 0·16, 0·33) for vitamin E, 0·51 (95 % CI 0·36, 0·73) for β-carotene, 0·43 (95 % CI 0·26, 0·70) for Se and 0·24 (95 % CI 0·17, 0·36) for the antioxidant score. A moderate-to-high dietary intake of retinol equivalents in quartiles 2-4 (v. 1) was found to be associated with a lower risk of hip fracture (OR range: 0·51-0·63, P< 0·05). No significant association was observed between dietary Zn or animal-derived vitamin A intake and hip fracture risk (P for trend >0·20). In conclusion, a higher dietary intake of vitamins C and E, β-carotene, and Se and a moderate-to-high dietary intake of retinol equivalents are associated with a lower risk of hip fracture in elderly Chinese. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25287150/Associations_between_the_dietary_intake_of_antioxidant_nutrients_and_the_risk_of_hip_fracture_in_elderly_Chinese:_a_case_control_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114514002773/type/journal_article DB - PRIME DP - Unbound Medicine ER -