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Cerebrospinal fluid biomarkers for neuropsychological symptoms in early stage of late-onset Alzheimer's disease.
Int J Neurosci 2015; 125(10):747-54IJ

Abstract

PURPOSE

In addition to testing blood, cerebrospinal fluid (CSF) has been analyzed in the search for biomarkers. The aim of this study was to identify biomarkers in CSF for neuropsychological symptoms in early-stage late-onset Alzheimer's disease (LOAD).

METHODS

CSF levels of beta-amyloid 1-42 (Aβ42), F2-isoprostanes (F2-IsoPs) and F4-neuroprostanes (F4-NPs) were assayed in nine patients with mild Alzheimer's disease (AD), nine patients with amnestic mild cognitive impairment (a-MCI) and nine individuals with normal mental function. The three groups underwent neuropsychological testing.

RESULTS

CSF levels of F2-IsoPs and F4-NPs did not significantly differ among the three groups. Aβ42 in CSF was significantly higher in the control group compared with the mild AD group (p < 0.001) and a-MCI group (p = 0.03). There was a significant positive correlation between the level of F2-IsoPs and Aβ42 in the a-MCI group and between the level of F2-IsoPs and F4-NPs in the mild AD group. In comparisons between the mild AD group and a-MCI group combined, the cognitive impairment (CI) group, with the control group, the median levels of F2-IsoPs and F4-NPs were significantly higher in the CI group and median level of Aβ42 was significantly lower in the CI group. Both the levels of F2-IsoPs and Aβ42 were significantly negatively correlated with paranoid and delusional ideation and total score for the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD).

CONCLUSIONS

The findings suggest CSF levels of Aβ42 and F2-IsoPs are associated with the severity of neuropsychological symptoms.

Authors+Show Affiliations

a Department of Neurology , Chang Gung Memorial Hospital and Chang Gung University College of Medicine , Taipei , Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25290083

Citation

Kuo, Hung-Chou, et al. "Cerebrospinal Fluid Biomarkers for Neuropsychological Symptoms in Early Stage of Late-onset Alzheimer's Disease." The International Journal of Neuroscience, vol. 125, no. 10, 2015, pp. 747-54.
Kuo HC, Yen HC, Huang CC, et al. Cerebrospinal fluid biomarkers for neuropsychological symptoms in early stage of late-onset Alzheimer's disease. Int J Neurosci. 2015;125(10):747-54.
Kuo, H. C., Yen, H. C., Huang, C. C., Hsu, W. C., Wei, H. J., & Lin, C. L. (2015). Cerebrospinal fluid biomarkers for neuropsychological symptoms in early stage of late-onset Alzheimer's disease. The International Journal of Neuroscience, 125(10), pp. 747-54. doi:10.3109/00207454.2014.971787.
Kuo HC, et al. Cerebrospinal Fluid Biomarkers for Neuropsychological Symptoms in Early Stage of Late-onset Alzheimer's Disease. Int J Neurosci. 2015;125(10):747-54. PubMed PMID: 25290083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid biomarkers for neuropsychological symptoms in early stage of late-onset Alzheimer's disease. AU - Kuo,Hung-Chou, AU - Yen,Hsiu-Chuan, AU - Huang,Chin-Chang, AU - Hsu,Wen-Chuin, AU - Wei,Hsing-Ju, AU - Lin,Chih-Lung, Y1 - 2014/10/29/ PY - 2014/10/8/entrez PY - 2014/10/8/pubmed PY - 2016/5/21/medline KW - Alzheimer's disease KW - Aβ42 KW - cerebrospinal fluid biomarkers KW - isoprostanes KW - neuroprostanes KW - neuropsychological symptom SP - 747 EP - 54 JF - The International journal of neuroscience JO - Int. J. Neurosci. VL - 125 IS - 10 N2 - PURPOSE: In addition to testing blood, cerebrospinal fluid (CSF) has been analyzed in the search for biomarkers. The aim of this study was to identify biomarkers in CSF for neuropsychological symptoms in early-stage late-onset Alzheimer's disease (LOAD). METHODS: CSF levels of beta-amyloid 1-42 (Aβ42), F2-isoprostanes (F2-IsoPs) and F4-neuroprostanes (F4-NPs) were assayed in nine patients with mild Alzheimer's disease (AD), nine patients with amnestic mild cognitive impairment (a-MCI) and nine individuals with normal mental function. The three groups underwent neuropsychological testing. RESULTS: CSF levels of F2-IsoPs and F4-NPs did not significantly differ among the three groups. Aβ42 in CSF was significantly higher in the control group compared with the mild AD group (p < 0.001) and a-MCI group (p = 0.03). There was a significant positive correlation between the level of F2-IsoPs and Aβ42 in the a-MCI group and between the level of F2-IsoPs and F4-NPs in the mild AD group. In comparisons between the mild AD group and a-MCI group combined, the cognitive impairment (CI) group, with the control group, the median levels of F2-IsoPs and F4-NPs were significantly higher in the CI group and median level of Aβ42 was significantly lower in the CI group. Both the levels of F2-IsoPs and Aβ42 were significantly negatively correlated with paranoid and delusional ideation and total score for the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD). CONCLUSIONS: The findings suggest CSF levels of Aβ42 and F2-IsoPs are associated with the severity of neuropsychological symptoms. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/25290083/Cerebrospinal_fluid_biomarkers_for_neuropsychological_symptoms_in_early_stage_of_late_onset_Alzheimer's_disease_ L2 - http://www.tandfonline.com/doi/full/10.3109/00207454.2014.971787 DB - PRIME DP - Unbound Medicine ER -