Tags

Type your tag names separated by a space and hit enter

Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze.
Brain Res Bull. 2014 Oct; 109:39-45.BR

Abstract

The dorsomedial hypothalamus (DMH) has long been associated with the regulation of escape, a panic-related defensive response. Previous evidence has shown that the activation of serotonin (5-HT) 1A and 2A receptors impairs escape behavior induced by the electrical stimulation of the same region. In this study we further explore the relationship of the DMH with defense by investigating the effects of 5-HT1A activation on escape behavior generated in male Wistar rats by an ethologically based aversive stimuli, exposure to one of the open arms of the elevated T-maze (ETM). Aside from escape, the ETM also allows the measurement of inhibitory avoidance, a defensive response associated with generalized anxiety disorder. To evaluate locomotor activity, after ETM measurements animals were submitted to an open field. Results showed that intra-DMH administration of the 5-HT1A receptor agonist 8-OH-DPAT inhibited escape expression. Local administration of the 5-HT1A antagonist WAY-100635 by its own was ineffective, but blocked the panicolytic-like effect of 8-OH-DPAT. Chronic (21 days) systemic treatment with imipramine potentiated the anti-escape effect of 8-OH-DPAT. No significant effects of treatment with 8-OH-DPAT or imipramine on avoidance latencies or the number of lines crossed in the open field were found. These results indicate that 5-HT1A receptors within the DMH may play a phasic inhibitory role on ETM escape expression. As previously proposed, facilitation of 5-HT1A-mediated neurotransmission in the DMH may be involved in the mechanism of action of anti-panic compounds.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Nascimento JO
Departamento de Psiquiatria e Psicologia Médica, Universidade Federal de São Paulo, 04038-020 São Paulo, Brazil.
Kikuchi LS
Departamento de Biociências, Universidade Federal de São Paulo, 11060-001 Santos, Brazil.
de Bortoli VC
Departamento de Ciências da Saúde, Universidade Federal do Espírito Santo, 29932-540 São Mateus, Brazil.
Zangrossi H
Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, Brazil.
Viana MB
Departamento de Biociências, Universidade Federal de São Paulo, 11060-001 Santos, Brazil. Electronic address: mviana@unifesp.br.

MeSH

8-Hydroxy-2-(di-n-propylamino)tetralinAnalysis of VarianceAnimalsAvoidance LearningDisease Models, AnimalDorsomedial Hypothalamic NucleusEscape ReactionExploratory BehaviorMaleMaze LearningMicroinjectionsPanic DisorderPiperazinesPyridinesRatsRats, WistarReaction TimeReceptor, Serotonin, 5-HT1ASerotonin AntagonistsSerotonin Receptor Agonists

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25290207

Citation

Nascimento, Juliana O G., et al. "Dorsomedial Hypothalamus Serotonin 1A Receptors Mediate a Panic-related Response in the Elevated T-maze." Brain Research Bulletin, vol. 109, 2014, pp. 39-45.
Nascimento JO, Kikuchi LS, de Bortoli VC, et al. Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze. Brain Res Bull. 2014;109:39-45.
Nascimento, J. O., Kikuchi, L. S., de Bortoli, V. C., Zangrossi, H., & Viana, M. B. (2014). Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze. Brain Research Bulletin, 109, 39-45. https://doi.org/10.1016/j.brainresbull.2014.09.011
Nascimento JO, et al. Dorsomedial Hypothalamus Serotonin 1A Receptors Mediate a Panic-related Response in the Elevated T-maze. Brain Res Bull. 2014;109:39-45. PubMed PMID: 25290207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze. AU - Nascimento,Juliana O G, AU - Kikuchi,Letícia Sumiko, AU - de Bortoli,Valquíria Camin, AU - Zangrossi,Hélio,Jr AU - Viana,Milena B, Y1 - 2014/10/05/ PY - 2014/08/04/received PY - 2014/09/23/revised PY - 2014/09/24/accepted PY - 2014/10/8/entrez PY - 2014/10/8/pubmed PY - 2015/7/15/medline KW - Dorsomedial hypothalamus KW - Elevated T-maze KW - Escape KW - Panic KW - Serotonin 1A receptors SP - 39 EP - 45 JF - Brain research bulletin JO - Brain Res Bull VL - 109 N2 - The dorsomedial hypothalamus (DMH) has long been associated with the regulation of escape, a panic-related defensive response. Previous evidence has shown that the activation of serotonin (5-HT) 1A and 2A receptors impairs escape behavior induced by the electrical stimulation of the same region. In this study we further explore the relationship of the DMH with defense by investigating the effects of 5-HT1A activation on escape behavior generated in male Wistar rats by an ethologically based aversive stimuli, exposure to one of the open arms of the elevated T-maze (ETM). Aside from escape, the ETM also allows the measurement of inhibitory avoidance, a defensive response associated with generalized anxiety disorder. To evaluate locomotor activity, after ETM measurements animals were submitted to an open field. Results showed that intra-DMH administration of the 5-HT1A receptor agonist 8-OH-DPAT inhibited escape expression. Local administration of the 5-HT1A antagonist WAY-100635 by its own was ineffective, but blocked the panicolytic-like effect of 8-OH-DPAT. Chronic (21 days) systemic treatment with imipramine potentiated the anti-escape effect of 8-OH-DPAT. No significant effects of treatment with 8-OH-DPAT or imipramine on avoidance latencies or the number of lines crossed in the open field were found. These results indicate that 5-HT1A receptors within the DMH may play a phasic inhibitory role on ETM escape expression. As previously proposed, facilitation of 5-HT1A-mediated neurotransmission in the DMH may be involved in the mechanism of action of anti-panic compounds. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/25290207/Dorsomedial_hypothalamus_serotonin_1A_receptors_mediate_a_panic_related_response_in_the_elevated_T_maze_ DB - PRIME DP - Unbound Medicine ER -