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Alzheimer's disease and epigenetic diet.
Neurochem Int. 2014 Dec; 78:105-16.NI

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease. Many efforts have been directed to prevent AD due to its rising prevalence and the lack of an effective curative treatment. Various epigenetic mechanisms are linked to pathogenesis of AD. Epigenetic alterations may occur through external factors and are known for their reversibility. Dietary factors can influence epigenetic mechanisms. Several neuroprotective nutrients have been shown to enhance cognition, memory and other impaired functions seen in AD. Within recent years neuroprotective nutrients have gained more attention in the field of epigenetic. A growing body of evidence suggest that epigenetic changes triggered by dietary nutrients have an important role in health and in prevention of some diseases, especially neurodegenerative disorders. Several studies have shown that folic acid, vitamin B12, choline, zinc, selenium, dietary polyphenols are capable of interacting with epigenetic mechanisms and ultimately gene expression. Epigenetic mechanisms resulting in neuronal dysfunction may be modified by diet. Therefore manipulation of epigenetic mechanisms via dietary nutrients may affect influence the vulnerability of neurons to degeneration which is seen in AD. The aim of this article is to provide a brief overview about the recent findings related to epigenetic alterations that are linked to AD pathogenesis, and to discuss the bioactive nutrients which can affect these epigenetic mechanisms.

Authors+Show Affiliations

Department of Medical Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey; Department of Medical Biochemistry, Yeni Yuzyıl University Medical Faculty, Istanbul, Turkey.Department of Medical Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. Electronic address: yldz.dincer@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25290336

Citation

Sezgin, Zeynep, and Yildiz Dincer. "Alzheimer's Disease and Epigenetic Diet." Neurochemistry International, vol. 78, 2014, pp. 105-16.
Sezgin Z, Dincer Y. Alzheimer's disease and epigenetic diet. Neurochem Int. 2014;78:105-16.
Sezgin, Z., & Dincer, Y. (2014). Alzheimer's disease and epigenetic diet. Neurochemistry International, 78, 105-16. https://doi.org/10.1016/j.neuint.2014.09.012
Sezgin Z, Dincer Y. Alzheimer's Disease and Epigenetic Diet. Neurochem Int. 2014;78:105-16. PubMed PMID: 25290336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alzheimer's disease and epigenetic diet. AU - Sezgin,Zeynep, AU - Dincer,Yildiz, Y1 - 2014/10/05/ PY - 2014/04/14/received PY - 2014/09/18/revised PY - 2014/09/29/accepted PY - 2014/10/8/entrez PY - 2014/10/8/pubmed PY - 2015/8/19/medline KW - (−)-epigallocatechin-3-gallate KW - Alzheimer's disease KW - Curcumin KW - Epigenetic KW - Isothiocyanates KW - Resveratrol SP - 105 EP - 16 JF - Neurochemistry international JO - Neurochem Int VL - 78 N2 - Alzheimer's disease (AD) is the most common neurodegenerative disease. Many efforts have been directed to prevent AD due to its rising prevalence and the lack of an effective curative treatment. Various epigenetic mechanisms are linked to pathogenesis of AD. Epigenetic alterations may occur through external factors and are known for their reversibility. Dietary factors can influence epigenetic mechanisms. Several neuroprotective nutrients have been shown to enhance cognition, memory and other impaired functions seen in AD. Within recent years neuroprotective nutrients have gained more attention in the field of epigenetic. A growing body of evidence suggest that epigenetic changes triggered by dietary nutrients have an important role in health and in prevention of some diseases, especially neurodegenerative disorders. Several studies have shown that folic acid, vitamin B12, choline, zinc, selenium, dietary polyphenols are capable of interacting with epigenetic mechanisms and ultimately gene expression. Epigenetic mechanisms resulting in neuronal dysfunction may be modified by diet. Therefore manipulation of epigenetic mechanisms via dietary nutrients may affect influence the vulnerability of neurons to degeneration which is seen in AD. The aim of this article is to provide a brief overview about the recent findings related to epigenetic alterations that are linked to AD pathogenesis, and to discuss the bioactive nutrients which can affect these epigenetic mechanisms. SN - 1872-9754 UR - https://www.unboundmedicine.com/medline/citation/25290336/Alzheimer's_disease_and_epigenetic_diet_ DB - PRIME DP - Unbound Medicine ER -