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The association between nut consumption and the risk of total and ischemic stroke in a German cohort study.
Eur J Clin Nutr 2015; 69(4):431-5EJ

Abstract

BACKGROUND/OBJECTIVES

Nuts have beneficial effects on coronary heart disease and many cardiovascular risk factors. However, their effect on stroke is less established, and no studies on the topic are available in Northern and Central European populations. Therefore, we aimed at investigating the association between nut consumption and the risk of stroke in a German population.

SUBJECTS/METHODS

We used data from a prospective cohort of 26,285 participants of the European Prospective Investigation into the Cancer and Nutrition Potsdam Study. During a median follow-up time of 8.3 years (interquartile range: 7.5-9.2), 288 incident cases of stroke occurred. Nut consumption (standard portion size of 50 g) was assessed at baseline with a semiquantitative food-frequency questionnaire.

RESULTS

The median nut intake was 0.82 g per day, interquartile range: 0.41-4.11. In the multivariable model, an increased risk of stroke was observed among participants who never consumed nuts (hazard ratio (HR): 1.56, 95% confidence interval: 1.17-2.08), compared with those consuming <½ portion/week. However, there was no evidence of a dose-response relationship between nut consumption and stroke. Compared with those who consumed <½ portion/week, the multivariable HR for total stroke was 1.06 (0.75-1.52) among those who consumed ½ to 1 portion/week and 1.37 (0.92-2.05) for those who consumed >1 portion/week. Similar nonsignificant associations were observed in stratified analysis for gender, or for fatal and nonfatal stroke.

CONCLUSIONS

We could not observe an association between nut consumption and the risk of developing stroke (fatal/nonfatal) in a population with low habitual nut consumption.

Authors+Show Affiliations

Research Group Cardiovascular Epidemiology, Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany.Department of Clinical Medicine, University of Bergen, Bergen, Norway.Department of Clinical Medicine, University of Bergen, Bergen, Norway.1] Department of Clinical Science, University of Bergen, Bergen, Norway [2] Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.Research Group Cardiovascular Epidemiology, Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany.Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany.1] Research Group Cardiovascular Epidemiology, Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany [2] Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25293435

Citation

di Giuseppe, R, et al. "The Association Between Nut Consumption and the Risk of Total and Ischemic Stroke in a German Cohort Study." European Journal of Clinical Nutrition, vol. 69, no. 4, 2015, pp. 431-5.
di Giuseppe R, Fjeld MK, Dierkes J, et al. The association between nut consumption and the risk of total and ischemic stroke in a German cohort study. Eur J Clin Nutr. 2015;69(4):431-5.
di Giuseppe, R., Fjeld, M. K., Dierkes, J., Theoflylaktopoulou, D., Arregui, M., Boeing, H., & Weikert, C. (2015). The association between nut consumption and the risk of total and ischemic stroke in a German cohort study. European Journal of Clinical Nutrition, 69(4), pp. 431-5. doi:10.1038/ejcn.2014.212.
di Giuseppe R, et al. The Association Between Nut Consumption and the Risk of Total and Ischemic Stroke in a German Cohort Study. Eur J Clin Nutr. 2015;69(4):431-5. PubMed PMID: 25293435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between nut consumption and the risk of total and ischemic stroke in a German cohort study. AU - di Giuseppe,R, AU - Fjeld,M K, AU - Dierkes,J, AU - Theoflylaktopoulou,D, AU - Arregui,M, AU - Boeing,H, AU - Weikert,C, Y1 - 2014/10/08/ PY - 2014/05/21/received PY - 2014/08/28/revised PY - 2014/08/29/accepted PY - 2014/10/9/entrez PY - 2014/10/9/pubmed PY - 2015/12/22/medline SP - 431 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 69 IS - 4 N2 - BACKGROUND/OBJECTIVES: Nuts have beneficial effects on coronary heart disease and many cardiovascular risk factors. However, their effect on stroke is less established, and no studies on the topic are available in Northern and Central European populations. Therefore, we aimed at investigating the association between nut consumption and the risk of stroke in a German population. SUBJECTS/METHODS: We used data from a prospective cohort of 26,285 participants of the European Prospective Investigation into the Cancer and Nutrition Potsdam Study. During a median follow-up time of 8.3 years (interquartile range: 7.5-9.2), 288 incident cases of stroke occurred. Nut consumption (standard portion size of 50 g) was assessed at baseline with a semiquantitative food-frequency questionnaire. RESULTS: The median nut intake was 0.82 g per day, interquartile range: 0.41-4.11. In the multivariable model, an increased risk of stroke was observed among participants who never consumed nuts (hazard ratio (HR): 1.56, 95% confidence interval: 1.17-2.08), compared with those consuming <½ portion/week. However, there was no evidence of a dose-response relationship between nut consumption and stroke. Compared with those who consumed <½ portion/week, the multivariable HR for total stroke was 1.06 (0.75-1.52) among those who consumed ½ to 1 portion/week and 1.37 (0.92-2.05) for those who consumed >1 portion/week. Similar nonsignificant associations were observed in stratified analysis for gender, or for fatal and nonfatal stroke. CONCLUSIONS: We could not observe an association between nut consumption and the risk of developing stroke (fatal/nonfatal) in a population with low habitual nut consumption. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/25293435/The_association_between_nut_consumption_and_the_risk_of_total_and_ischemic_stroke_in_a_German_cohort_study_ L2 - http://dx.doi.org/10.1038/ejcn.2014.212 DB - PRIME DP - Unbound Medicine ER -