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Effect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fibrosis score and HSENSI in patients with nonalcoholic steatohepatitis: a MR imaging-based pilot open-label study.
Arq Gastroenterol. 2014 Jul-Sep; 51(3):261-8.AG

Abstract

CONTEXT

Limited clinical data suggest Helicobacter pylori (Hp) infection may contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis.

OBJECTIVES

The effect of Hp eradication on hepatic steatosis (magnetic resonance imaging), nonalcoholic fatty liver disease fibrosis score and HSENSI (Homocysteine, serum glutamic oxaloacetic transaminase, Erythrocyte sedimentation rate, nonalcoholic steatohepatitis Index) in nonalcoholic steatohepatitis patients.

METHODS

Thirteen adult patients with biopsy-proven nonalcoholic steatohepatitis, asymptomatic for gastrointestinal disease, underwent 13C urea breath test; Hp positive patients received eradication therapy until repeat test become negative. Hepatic fat fraction, standard biochemical tests and calculation of nonalcoholic fatty liver disease fibrosis score and HSENSI were performed at baseline and month 12.

RESULTS

Hepatic fat fraction was similar for between and within group comparisons. Nonalcoholic fatty liver disease fibrosis score showed a non-significant trend towards decrease in Hp(+) [-0.34 (-1.39-0.29) at baseline and -0.24 (-0.99-0.71) at month 12; P = 0.116], whereas increase in Hp(-) group [-0.38 (-1.72-0.11) and -0.56 (-1.43-0.46), respectively; P = 0.249]. HSENSI was significantly decreased only in Hp(+) group [1.0 (1.0-2.0) at baseline and 1.0 (0-1.0) at month 12; P = 0.048].

CONCLUSIONS

Hp eradication had no long-term effect on hepatic steatosis, but showed a trend towards improvement in nonalcoholic fatty liver disease fibrosis score and HSENSI. These results warrant larger studies with paired biopsies.

Authors+Show Affiliations

Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece.Department of Radiology, 424 General Military Hospital, Thessaloniki, Macedonia, Greece.Department of Radiology, Ippokration Hospital, Thessaloniki, Macedonia, Greece.Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece.Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece.Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25296089

Citation

Polyzos, Stergios A., et al. "Effect of Helicobacter Pylori Eradication On Hepatic Steatosis, NAFLD Fibrosis Score and HSENSI in Patients With Nonalcoholic Steatohepatitis: a MR Imaging-based Pilot Open-label Study." Arquivos De Gastroenterologia, vol. 51, no. 3, 2014, pp. 261-8.
Polyzos SA, Nikolopoulos P, Stogianni A, et al. Effect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fibrosis score and HSENSI in patients with nonalcoholic steatohepatitis: a MR imaging-based pilot open-label study. Arq Gastroenterol. 2014;51(3):261-8.
Polyzos, S. A., Nikolopoulos, P., Stogianni, A., Romiopoulos, I., Katsinelos, P., & Kountouras, J. (2014). Effect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fibrosis score and HSENSI in patients with nonalcoholic steatohepatitis: a MR imaging-based pilot open-label study. Arquivos De Gastroenterologia, 51(3), 261-8.
Polyzos SA, et al. Effect of Helicobacter Pylori Eradication On Hepatic Steatosis, NAFLD Fibrosis Score and HSENSI in Patients With Nonalcoholic Steatohepatitis: a MR Imaging-based Pilot Open-label Study. Arq Gastroenterol. 2014 Jul-Sep;51(3):261-8. PubMed PMID: 25296089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fibrosis score and HSENSI in patients with nonalcoholic steatohepatitis: a MR imaging-based pilot open-label study. AU - Polyzos,Stergios A, AU - Nikolopoulos,Panagiotis, AU - Stogianni,Angeliki, AU - Romiopoulos,Iordanis, AU - Katsinelos,Panagiotis, AU - Kountouras,Jannis, PY - 2014/03/03/received PY - 2014/04/30/accepted PY - 2014/10/9/entrez PY - 2014/10/9/pubmed PY - 2015/1/30/medline SP - 261 EP - 8 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 51 IS - 3 N2 - CONTEXT: Limited clinical data suggest Helicobacter pylori (Hp) infection may contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. OBJECTIVES: The effect of Hp eradication on hepatic steatosis (magnetic resonance imaging), nonalcoholic fatty liver disease fibrosis score and HSENSI (Homocysteine, serum glutamic oxaloacetic transaminase, Erythrocyte sedimentation rate, nonalcoholic steatohepatitis Index) in nonalcoholic steatohepatitis patients. METHODS: Thirteen adult patients with biopsy-proven nonalcoholic steatohepatitis, asymptomatic for gastrointestinal disease, underwent 13C urea breath test; Hp positive patients received eradication therapy until repeat test become negative. Hepatic fat fraction, standard biochemical tests and calculation of nonalcoholic fatty liver disease fibrosis score and HSENSI were performed at baseline and month 12. RESULTS: Hepatic fat fraction was similar for between and within group comparisons. Nonalcoholic fatty liver disease fibrosis score showed a non-significant trend towards decrease in Hp(+) [-0.34 (-1.39-0.29) at baseline and -0.24 (-0.99-0.71) at month 12; P = 0.116], whereas increase in Hp(-) group [-0.38 (-1.72-0.11) and -0.56 (-1.43-0.46), respectively; P = 0.249]. HSENSI was significantly decreased only in Hp(+) group [1.0 (1.0-2.0) at baseline and 1.0 (0-1.0) at month 12; P = 0.048]. CONCLUSIONS: Hp eradication had no long-term effect on hepatic steatosis, but showed a trend towards improvement in nonalcoholic fatty liver disease fibrosis score and HSENSI. These results warrant larger studies with paired biopsies. SN - 1678-4219 UR - https://www.unboundmedicine.com/medline/citation/25296089/Effect_of_Helicobacter_pylori_eradication_on_hepatic_steatosis_NAFLD_fibrosis_score_and_HSENSI_in_patients_with_nonalcoholic_steatohepatitis:_a_MR_imaging_based_pilot_open_label_study_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032014000300261&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -