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Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study.
Eur J Nutr. 2015 Sep; 54(6):981-90.EJ

Abstract

PURPOSE

We examined whether consumption of total dairy and dairy subgroups was related to incident stroke and coronary heart disease (CHD) in a general older Dutch population.

METHODS

The study involved 4,235 participants of the Rotterdam Study aged 55 and over who were free of cardiovascular disease (CVD) and diabetes at baseline (1990-1993). Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) for the intake of total dairy and dairy subgroups in relation to incident CVD events.

RESULTS

Median intake of total dairy was 397 g/day, which mainly comprised low-fat dairy products (median intake of 247 g/day). During a median follow-up time of 17.3 years, 564 strokes (182 fatal) and 567 CHD events (350 fatal) occurred. Total dairy, milk, low-fat dairy, and fermented dairy were not significantly related to incident stroke or fatal stroke (p > 0.2 for upper vs. lower intake categories). High-fat dairy was significantly inversely related to fatal stroke (HR of 0.88 per 100 g/day; 95% CI 0.79, 0.99), but not to incident stroke (HR of 0.96 per 100 g/day; 95% CI 0.90, 1.02). Total dairy or dairy subgroups were not significantly related to incident CHD or fatal CHD (HRs between 0.98 and 1.05 per 100 g/day, all p > 0.35).

CONCLUSIONS

In this long-term follow-up study of older Dutch subjects, total dairy consumption or the intake of specific dairy products was not related to the occurrence of CVD events. The observed inverse association between high-fat dairy and fatal stroke warrants confirmation in other studies.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25296885

Citation

Praagman, Jaike, et al. "Dairy Products and the Risk of Stroke and Coronary Heart Disease: the Rotterdam Study." European Journal of Nutrition, vol. 54, no. 6, 2015, pp. 981-90.
Praagman J, Franco OH, Ikram MA, et al. Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study. Eur J Nutr. 2015;54(6):981-90.
Praagman, J., Franco, O. H., Ikram, M. A., Soedamah-Muthu, S. S., Engberink, M. F., van Rooij, F. J., Hofman, A., & Geleijnse, J. M. (2015). Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study. European Journal of Nutrition, 54(6), 981-90. https://doi.org/10.1007/s00394-014-0774-0
Praagman J, et al. Dairy Products and the Risk of Stroke and Coronary Heart Disease: the Rotterdam Study. Eur J Nutr. 2015;54(6):981-90. PubMed PMID: 25296885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study. AU - Praagman,Jaike, AU - Franco,Oscar H, AU - Ikram,M Arfan, AU - Soedamah-Muthu,Sabita S, AU - Engberink,Mariëlle F, AU - van Rooij,Frank J A, AU - Hofman,Albert, AU - Geleijnse,Johanna M, Y1 - 2014/10/09/ PY - 2014/04/30/received PY - 2014/09/23/accepted PY - 2014/10/10/entrez PY - 2014/10/10/pubmed PY - 2016/5/19/medline SP - 981 EP - 90 JF - European journal of nutrition JO - Eur J Nutr VL - 54 IS - 6 N2 - PURPOSE: We examined whether consumption of total dairy and dairy subgroups was related to incident stroke and coronary heart disease (CHD) in a general older Dutch population. METHODS: The study involved 4,235 participants of the Rotterdam Study aged 55 and over who were free of cardiovascular disease (CVD) and diabetes at baseline (1990-1993). Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) for the intake of total dairy and dairy subgroups in relation to incident CVD events. RESULTS: Median intake of total dairy was 397 g/day, which mainly comprised low-fat dairy products (median intake of 247 g/day). During a median follow-up time of 17.3 years, 564 strokes (182 fatal) and 567 CHD events (350 fatal) occurred. Total dairy, milk, low-fat dairy, and fermented dairy were not significantly related to incident stroke or fatal stroke (p > 0.2 for upper vs. lower intake categories). High-fat dairy was significantly inversely related to fatal stroke (HR of 0.88 per 100 g/day; 95% CI 0.79, 0.99), but not to incident stroke (HR of 0.96 per 100 g/day; 95% CI 0.90, 1.02). Total dairy or dairy subgroups were not significantly related to incident CHD or fatal CHD (HRs between 0.98 and 1.05 per 100 g/day, all p > 0.35). CONCLUSIONS: In this long-term follow-up study of older Dutch subjects, total dairy consumption or the intake of specific dairy products was not related to the occurrence of CVD events. The observed inverse association between high-fat dairy and fatal stroke warrants confirmation in other studies. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/25296885/Dairy_products_and_the_risk_of_stroke_and_coronary_heart_disease:_the_Rotterdam_Study_ L2 - https://dx.doi.org/10.1007/s00394-014-0774-0 DB - PRIME DP - Unbound Medicine ER -