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Possibility of scrub typhus in fever of unknown origin (FUO) cases: an experience from Rajasthan.
Indian J Med Microbiol. 2014 Oct-Dec; 32(4):387-90.IJ

Abstract

PURPOSE

Fever of unknown origin (FUO) has multiple causes. Scrub typhus is less known cause of FUO in India. The present study reports a recent epidemic of scrub typhus amongst cases of FUO from different areas of Rajasthan, India. There was high mortality in undiagnosed cases of FUO which lead to the diagnosis of scrub typhus.

OBJECTIVE

To study the possibility of scrub typhus as a causative factor in FUO cases by qualitative detection of IgM antibodies with ELISA.

MATERIALS AND METHODS

From September 2012 to December 2012, 271 serum samples of FUO cases were analysed for IgM antibodies to Orientia tsutsugamushi along with dengue, malaria, typhoid, tuberculosis and brucellosis.

RESULTS

Scrub typhus IgM antibodies by ELISA were detected in 133 (49.1%) patients. Scrub typhus positivity was significantly higher among female in comparison to males (P<0.05). Maximum positivity of scrub typhus was found in females of 46-60 years age group. The laboratory parameters were abnormal in most of the patients as evident by thrombocytopenia (63%), deranged liver functions (56%) and renal functions (25%).

CONCLUSION

The present study emphasises the importance of scrub typhus among cases of FUO especially after rainy season and during early cooler months. The study also highlights the significance of ELISA method for rapid and early reporting and ruling out scrub typhus in FUO cases.

Authors+Show Affiliations

Department of Microbiology and Immunology, Sawai Man Singh Medial College, Jaipur, Rajasthan, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25297022

Citation

Bithu, R, et al. "Possibility of Scrub Typhus in Fever of Unknown Origin (FUO) Cases: an Experience From Rajasthan." Indian Journal of Medical Microbiology, vol. 32, no. 4, 2014, pp. 387-90.
Bithu R, Kanodia V, Maheshwari RK. Possibility of scrub typhus in fever of unknown origin (FUO) cases: an experience from Rajasthan. Indian J Med Microbiol. 2014;32(4):387-90.
Bithu, R., Kanodia, V., & Maheshwari, R. K. (2014). Possibility of scrub typhus in fever of unknown origin (FUO) cases: an experience from Rajasthan. Indian Journal of Medical Microbiology, 32(4), 387-90. https://doi.org/10.4103/0255-0857.142241
Bithu R, Kanodia V, Maheshwari RK. Possibility of Scrub Typhus in Fever of Unknown Origin (FUO) Cases: an Experience From Rajasthan. Indian J Med Microbiol. 2014;32(4):387-90. PubMed PMID: 25297022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possibility of scrub typhus in fever of unknown origin (FUO) cases: an experience from Rajasthan. AU - Bithu,R, AU - Kanodia,V, AU - Maheshwari,R K, PY - 2014/10/10/entrez PY - 2014/10/10/pubmed PY - 2015/6/24/medline SP - 387 EP - 90 JF - Indian journal of medical microbiology JO - Indian J Med Microbiol VL - 32 IS - 4 N2 - PURPOSE: Fever of unknown origin (FUO) has multiple causes. Scrub typhus is less known cause of FUO in India. The present study reports a recent epidemic of scrub typhus amongst cases of FUO from different areas of Rajasthan, India. There was high mortality in undiagnosed cases of FUO which lead to the diagnosis of scrub typhus. OBJECTIVE: To study the possibility of scrub typhus as a causative factor in FUO cases by qualitative detection of IgM antibodies with ELISA. MATERIALS AND METHODS: From September 2012 to December 2012, 271 serum samples of FUO cases were analysed for IgM antibodies to Orientia tsutsugamushi along with dengue, malaria, typhoid, tuberculosis and brucellosis. RESULTS: Scrub typhus IgM antibodies by ELISA were detected in 133 (49.1%) patients. Scrub typhus positivity was significantly higher among female in comparison to males (P<0.05). Maximum positivity of scrub typhus was found in females of 46-60 years age group. The laboratory parameters were abnormal in most of the patients as evident by thrombocytopenia (63%), deranged liver functions (56%) and renal functions (25%). CONCLUSION: The present study emphasises the importance of scrub typhus among cases of FUO especially after rainy season and during early cooler months. The study also highlights the significance of ELISA method for rapid and early reporting and ruling out scrub typhus in FUO cases. SN - 1998-3646 UR - https://www.unboundmedicine.com/medline/citation/25297022/Possibility_of_scrub_typhus_in_fever_of_unknown_origin__FUO__cases:_an_experience_from_Rajasthan_ L2 - http://www.ijmm.org/article.asp?issn=0255-0857;year=2014;volume=32;issue=4;spage=387;epage=390;aulast=Bithu DB - PRIME DP - Unbound Medicine ER -