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Relationship between the GOLD combined COPD assessment staging system and bacterial isolation.

Abstract

BACKGROUND

Acute exacerbations, which are a significant cause of mortality and morbidity, adversely affect chronic obstructive pulmonary disease (COPD) prognosis by accelerating loss of lung function. It is important to know the microorganisms that commonly cause exacerbations in the patient groups classified according to clinical and functional characteristics for fast and accurate treatment of acute exacerbations.

OBJECTIVES

The last Global Initiative for Chronic Obstructive Lung Disease (GOLD) publication recommended a new staging system containing obstruction degree, frequency of exacerbations, and quality of life questionnaires. This study is designed to analyze the relationship between the bacteria isolated in acute exacerbations and new GOLD stages.

METHODS

Potentially pathogenic bacteria (PPB) isolation with culture and polymerase chain reaction methods were obtained from 114 acute exacerbation COPD patients, classified into A, B, C, and D groups by analyzing the forced expiratory volume in 1 second (FEV1) value, COPD Assessment Test (CAT) score, and exacerbation frequency according to the new GOLD staging system.

RESULTS

There was a significant correlation between exacerbation frequency and PPB isolation (P=0.002). There was no relationship between GOLD stage, FEV1, and CAT score with PPB isolation. The isolated bacteria diversity and mixed infection frequency were higher in the GOLD stage D group. Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii were isolated only from D group patients.

CONCLUSION

Bacterial infection may cause an acute exacerbation equally in each stage for COPD. The difference in bacterial etiology is more related to exacerbation frequency than FEV1 and CAT scores for an acute exacerbation. Determining exacerbation frequency is significant for treatment success in empirical antibiotic selection.

Authors+Show Affiliations

Department of Respiratory Medicine, Sakarya University, Sakarya, Turkey.Department of Microbiology, Sakarya University, Sakarya, Turkey.Department of Microbiology, Konya Numune Hospital, Konya, Turkey.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25298733

Citation

Aydemir, Yusuf, et al. "Relationship Between the GOLD Combined COPD Assessment Staging System and Bacterial Isolation." International Journal of Chronic Obstructive Pulmonary Disease, vol. 9, 2014, pp. 1045-51.
Aydemir Y, Aydemir Ö, Kalem F. Relationship between the GOLD combined COPD assessment staging system and bacterial isolation. Int J Chron Obstruct Pulmon Dis. 2014;9:1045-51.
Aydemir, Y., Aydemir, Ö., & Kalem, F. (2014). Relationship between the GOLD combined COPD assessment staging system and bacterial isolation. International Journal of Chronic Obstructive Pulmonary Disease, 9, 1045-51. https://doi.org/10.2147/COPD.S70620
Aydemir Y, Aydemir Ö, Kalem F. Relationship Between the GOLD Combined COPD Assessment Staging System and Bacterial Isolation. Int J Chron Obstruct Pulmon Dis. 2014;9:1045-51. PubMed PMID: 25298733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between the GOLD combined COPD assessment staging system and bacterial isolation. AU - Aydemir,Yusuf, AU - Aydemir,Özlem, AU - Kalem,Fatma, Y1 - 2014/09/27/ PY - 2014/10/10/entrez PY - 2014/10/10/pubmed PY - 2015/2/25/medline KW - GOLD KW - acute exacerbation KW - bacterial etiology KW - chronic obstructive pulmonary disease KW - polymerase chain reaction SP - 1045 EP - 51 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 9 N2 - BACKGROUND: Acute exacerbations, which are a significant cause of mortality and morbidity, adversely affect chronic obstructive pulmonary disease (COPD) prognosis by accelerating loss of lung function. It is important to know the microorganisms that commonly cause exacerbations in the patient groups classified according to clinical and functional characteristics for fast and accurate treatment of acute exacerbations. OBJECTIVES: The last Global Initiative for Chronic Obstructive Lung Disease (GOLD) publication recommended a new staging system containing obstruction degree, frequency of exacerbations, and quality of life questionnaires. This study is designed to analyze the relationship between the bacteria isolated in acute exacerbations and new GOLD stages. METHODS: Potentially pathogenic bacteria (PPB) isolation with culture and polymerase chain reaction methods were obtained from 114 acute exacerbation COPD patients, classified into A, B, C, and D groups by analyzing the forced expiratory volume in 1 second (FEV1) value, COPD Assessment Test (CAT) score, and exacerbation frequency according to the new GOLD staging system. RESULTS: There was a significant correlation between exacerbation frequency and PPB isolation (P=0.002). There was no relationship between GOLD stage, FEV1, and CAT score with PPB isolation. The isolated bacteria diversity and mixed infection frequency were higher in the GOLD stage D group. Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii were isolated only from D group patients. CONCLUSION: Bacterial infection may cause an acute exacerbation equally in each stage for COPD. The difference in bacterial etiology is more related to exacerbation frequency than FEV1 and CAT scores for an acute exacerbation. Determining exacerbation frequency is significant for treatment success in empirical antibiotic selection. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/25298733/Relationship_between_the_GOLD_combined_COPD_assessment_staging_system_and_bacterial_isolation_ L2 - https://dx.doi.org/10.2147/COPD.S70620 DB - PRIME DP - Unbound Medicine ER -