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Initial experience of bedaquiline use in a series of drug-resistant tuberculosis patients from India.
Int J Tuberc Lung Dis. 2014 Nov; 18(11):1315-8.IJ

Abstract

Drug-resistant tuberculosis (DR-TB) is a major problem both in India and worldwide. Newer drugs such as TMC-207 (bedaquiline) may have an important role to play in making up an effective drug regimen in such cases. There have been a few reports of bedaquiline use in a non-trial setting from Europe. Our series of five patients is the first series of DR-TB patients from India to receive bedaquiline. All five patients showed striking improvement, with microbiological conversion and an absence of notable adverse effects (e.g., prolonged QTcF), indicating the potential impact of this drug in such a population.

Authors+Show Affiliations

Department of Respiratory Medicine, Medical Research Centre, P D Hinduja National Hospital, Mumbai, India.Department of Respiratory Medicine, Medical Research Centre, P D Hinduja National Hospital, Mumbai, India.Department of Respiratory Medicine, Medical Research Centre, P D Hinduja National Hospital, Mumbai, India.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25299863

Citation

Udwadia, Z F., et al. "Initial Experience of Bedaquiline Use in a Series of Drug-resistant Tuberculosis Patients From India." The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, vol. 18, no. 11, 2014, pp. 1315-8.
Udwadia ZF, Amale RA, Mullerpattan JB. Initial experience of bedaquiline use in a series of drug-resistant tuberculosis patients from India. Int J Tuberc Lung Dis. 2014;18(11):1315-8.
Udwadia, Z. F., Amale, R. A., & Mullerpattan, J. B. (2014). Initial experience of bedaquiline use in a series of drug-resistant tuberculosis patients from India. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, 18(11), 1315-8. https://doi.org/10.5588/ijtld.14.0284
Udwadia ZF, Amale RA, Mullerpattan JB. Initial Experience of Bedaquiline Use in a Series of Drug-resistant Tuberculosis Patients From India. Int J Tuberc Lung Dis. 2014;18(11):1315-8. PubMed PMID: 25299863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Initial experience of bedaquiline use in a series of drug-resistant tuberculosis patients from India. AU - Udwadia,Z F, AU - Amale,R A, AU - Mullerpattan,J B, PY - 2014/10/10/entrez PY - 2014/10/10/pubmed PY - 2015/6/13/medline SP - 1315 EP - 8 JF - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JO - Int. J. Tuberc. Lung Dis. VL - 18 IS - 11 N2 - Drug-resistant tuberculosis (DR-TB) is a major problem both in India and worldwide. Newer drugs such as TMC-207 (bedaquiline) may have an important role to play in making up an effective drug regimen in such cases. There have been a few reports of bedaquiline use in a non-trial setting from Europe. Our series of five patients is the first series of DR-TB patients from India to receive bedaquiline. All five patients showed striking improvement, with microbiological conversion and an absence of notable adverse effects (e.g., prolonged QTcF), indicating the potential impact of this drug in such a population. SN - 1815-7920 UR - https://www.unboundmedicine.com/medline/citation/25299863/Initial_experience_of_bedaquiline_use_in_a_series_of_drug_resistant_tuberculosis_patients_from_India_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1027-3719&volume=18&issue=11&spage=1315&aulast=Udwadia DB - PRIME DP - Unbound Medicine ER -