Tags

Type your tag names separated by a space and hit enter

Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials.

Abstract

The aim of this study was to assess the clinical efficacy and safety of oral ginger for symptomatic treatment of osteoarthritis (OA) by carrying out a systematic literature search followed by meta-analyses on selected studies. Inclusion criteria were randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years. Outcomes were reduction in pain and reduction in disability. Harm was assessed as withdrawals due to adverse events. The efficacy effect size was estimated using Hedges' standardized mean difference (SMD), and safety by risk ratio (RR). Standard random-effects meta-analysis was used, and inconsistency was evaluated by the I-squared index (I(2)). Out of 122 retrieved references, 117 were discarded, leaving five trials (593 patients) for meta-analyses. The majority reported relevant randomization procedures and blinding, but an inadequate intention-to-treat (ITT) analysis. Following ginger intake, a statistically significant pain reduction SMD = -0.30 ([95% CI: [(-0.50, -0.09)], P = 0.005]) with a low degree of inconsistency among trials (I(2) = 27%), and a statistically significant reduction in disability SMD = -0.22 ([95% CI: ([-0.39, -0.04)]; P = 0.01; I(2) = 0%]) were seen, both in favor of ginger. Patients given ginger were more than twice as likely to discontinue treatment compared to placebo ([RR = 2.33; 95% CI: (1.04, 5.22)]; P = 0.04; I(2) = 0%]). Ginger was modestly efficacious and reasonably safe for treatment of OA. We judged the evidence to be of moderate quality, based on the small number of participants and inadequate ITT populations. Prospero: CRD42011001777.

Links

  • FREE Publisher Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark. Electronic address: Else.Marie.Bartels@regionh.dk.

    ,

    The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.

    ,

    The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.

    ,

    David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA.

    ,

    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

    ,

    The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.

    ,

    Division of Rheumatology, Orthopedics and Dermatology University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, UK.

    The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark; Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

    Source

    Osteoarthritis and cartilage 23:1 2015 Jan pg 13-21

    MeSH

    Ginger
    Humans
    Osteoarthritis
    Phytotherapy
    Placebos
    Plant Extracts
    Randomized Controlled Trials as Topic
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25300574

    Citation

    Bartels, E M., et al. "Efficacy and Safety of Ginger in Osteoarthritis Patients: a Meta-analysis of Randomized Placebo-controlled Trials." Osteoarthritis and Cartilage, vol. 23, no. 1, 2015, pp. 13-21.
    Bartels EM, Folmer VN, Bliddal H, et al. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthr Cartil. 2015;23(1):13-21.
    Bartels, E. M., Folmer, V. N., Bliddal, H., Altman, R. D., Juhl, C., Tarp, S., ... Christensen, R. (2015). Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis and Cartilage, 23(1), pp. 13-21. doi:10.1016/j.joca.2014.09.024.
    Bartels EM, et al. Efficacy and Safety of Ginger in Osteoarthritis Patients: a Meta-analysis of Randomized Placebo-controlled Trials. Osteoarthr Cartil. 2015;23(1):13-21. PubMed PMID: 25300574.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. AU - Bartels,E M, AU - Folmer,V N, AU - Bliddal,H, AU - Altman,R D, AU - Juhl,C, AU - Tarp,S, AU - Zhang,W, AU - Christensen,R, Y1 - 2014/10/07/ PY - 2014/05/14/received PY - 2014/09/08/revised PY - 2014/09/30/accepted PY - 2014/10/11/entrez PY - 2014/10/11/pubmed PY - 2015/7/24/medline KW - Ginger KW - Hip KW - Knee KW - Meta-analysis KW - Osteoarthritis KW - Pain SP - 13 EP - 21 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 23 IS - 1 N2 - The aim of this study was to assess the clinical efficacy and safety of oral ginger for symptomatic treatment of osteoarthritis (OA) by carrying out a systematic literature search followed by meta-analyses on selected studies. Inclusion criteria were randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years. Outcomes were reduction in pain and reduction in disability. Harm was assessed as withdrawals due to adverse events. The efficacy effect size was estimated using Hedges' standardized mean difference (SMD), and safety by risk ratio (RR). Standard random-effects meta-analysis was used, and inconsistency was evaluated by the I-squared index (I(2)). Out of 122 retrieved references, 117 were discarded, leaving five trials (593 patients) for meta-analyses. The majority reported relevant randomization procedures and blinding, but an inadequate intention-to-treat (ITT) analysis. Following ginger intake, a statistically significant pain reduction SMD = -0.30 ([95% CI: [(-0.50, -0.09)], P = 0.005]) with a low degree of inconsistency among trials (I(2) = 27%), and a statistically significant reduction in disability SMD = -0.22 ([95% CI: ([-0.39, -0.04)]; P = 0.01; I(2) = 0%]) were seen, both in favor of ginger. Patients given ginger were more than twice as likely to discontinue treatment compared to placebo ([RR = 2.33; 95% CI: (1.04, 5.22)]; P = 0.04; I(2) = 0%]). Ginger was modestly efficacious and reasonably safe for treatment of OA. We judged the evidence to be of moderate quality, based on the small number of participants and inadequate ITT populations. Prospero: CRD42011001777. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/25300574/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(14)01276-X DB - PRIME DP - Unbound Medicine ER -