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Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells.
Ophthalmic Res. 2014; 52(3):151-9.OR

Abstract

We here provide a brief summary of the characteristics of transient receptor potential channels (TRPs) identified in corneal tissue layers and cells. In general, TRPs are nonselective cation channels which are Ca(2+) permeable. Most TRPs serve as thermosensitive molecular sensors (thermo-TRPs). Based on their functional importance, the possibilities are described for drug-targeting TRP activity in a clinical setting. TRPs are expressed in various tissues of the eye including both human corneal epithelial and endothelial layers as well as stromal fibroblasts and stromal nerve fibers. TRP vanilloid type 1 (TRPV1) heat receptor, also known as capsaicin receptor, along with TRP melastatin type 8 (TRPM8) cold receptor, which is also known as menthol receptor, are prototypes of the thermo-TRP family. The TRPV1 functional channel is the most investigated TRP channel in these tissues, owing to its contribution to maintaining tissue homeostasis as well as eliciting wound healing responses to injury. Other thermo-TRP family members identified in these tissues are TRPV2, 3 and 4. Finally, there is the TRP ankyrin type 1 (TRPA1) cold receptor. All of these thermo-TRPs can be activated within specific temperature ranges and transduce such inputs into chemical and electrical signals. Although several recent studies have begun to unravel complex roles for thermo-TRPs such as TRPV1 in corneal layers and resident cells, additional studies are needed to further elucidate their roles in health and disease.

Authors+Show Affiliations

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25301091

Citation

Mergler, Stefan, et al. "Temperature-sensitive Transient Receptor Potential Channels in Corneal Tissue Layers and Cells." Ophthalmic Research, vol. 52, no. 3, 2014, pp. 151-9.
Mergler S, Valtink M, Takayoshi S, et al. Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells. Ophthalmic Res. 2014;52(3):151-9.
Mergler, S., Valtink, M., Takayoshi, S., Okada, Y., Miyajima, M., Saika, S., & Reinach, P. S. (2014). Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells. Ophthalmic Research, 52(3), 151-9. https://doi.org/10.1159/000365334
Mergler S, et al. Temperature-sensitive Transient Receptor Potential Channels in Corneal Tissue Layers and Cells. Ophthalmic Res. 2014;52(3):151-9. PubMed PMID: 25301091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells. AU - Mergler,Stefan, AU - Valtink,Monika, AU - Takayoshi,Sumioka, AU - Okada,Yuka, AU - Miyajima,Masayasu, AU - Saika,Shizuya, AU - Reinach,Peter S, Y1 - 2014/10/08/ PY - 2014/02/13/received PY - 2014/06/16/accepted PY - 2014/10/11/entrez PY - 2014/10/11/pubmed PY - 2015/5/23/medline SP - 151 EP - 9 JF - Ophthalmic research JO - Ophthalmic Res VL - 52 IS - 3 N2 - We here provide a brief summary of the characteristics of transient receptor potential channels (TRPs) identified in corneal tissue layers and cells. In general, TRPs are nonselective cation channels which are Ca(2+) permeable. Most TRPs serve as thermosensitive molecular sensors (thermo-TRPs). Based on their functional importance, the possibilities are described for drug-targeting TRP activity in a clinical setting. TRPs are expressed in various tissues of the eye including both human corneal epithelial and endothelial layers as well as stromal fibroblasts and stromal nerve fibers. TRP vanilloid type 1 (TRPV1) heat receptor, also known as capsaicin receptor, along with TRP melastatin type 8 (TRPM8) cold receptor, which is also known as menthol receptor, are prototypes of the thermo-TRP family. The TRPV1 functional channel is the most investigated TRP channel in these tissues, owing to its contribution to maintaining tissue homeostasis as well as eliciting wound healing responses to injury. Other thermo-TRP family members identified in these tissues are TRPV2, 3 and 4. Finally, there is the TRP ankyrin type 1 (TRPA1) cold receptor. All of these thermo-TRPs can be activated within specific temperature ranges and transduce such inputs into chemical and electrical signals. Although several recent studies have begun to unravel complex roles for thermo-TRPs such as TRPV1 in corneal layers and resident cells, additional studies are needed to further elucidate their roles in health and disease. SN - 1423-0259 UR - https://www.unboundmedicine.com/medline/citation/25301091/Temperature_sensitive_transient_receptor_potential_channels_in_corneal_tissue_layers_and_cells_ L2 - https://www.karger.com?DOI=10.1159/000365334 DB - PRIME DP - Unbound Medicine ER -