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Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.
Neuro Oncol 2015; 17(5):652-62NO

Abstract

The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to a unique brain microenvironment and its cellular interactions. Despite extensive evidence of a role for microRNAs in GBM cells, little is known about microRNA-dependent communication between different cellular compartments of the microenvironment that may contribute to the tumor phenotype. While the majority of microRNAs are found intracellularly, a significant number of microRNAs have been observed outside of cells, often encapsulated in secreted extracellular vesicles (EVs). The function of these circulating/secreted microRNAs has not been explored in the context of the brain tumor microenvironment. Establishing how microRNAs are involved in the regulation of oncogenic signaling networks between tumor cells and stroma is likely to add a needed additional layer of complexity to the tumor network, consisting of intercellular communication. More importantly, microRNA/EV signaling may provide an additional therapeutic target for this deadly disease.

Authors+Show Affiliations

Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

25301812

Citation

Godlewski, Jakub, et al. "Belonging to a network--microRNAs, Extracellular Vesicles, and the Glioblastoma Microenvironment." Neuro-oncology, vol. 17, no. 5, 2015, pp. 652-62.
Godlewski J, Krichevsky AM, Johnson MD, et al. Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro-oncology. 2015;17(5):652-62.
Godlewski, J., Krichevsky, A. M., Johnson, M. D., Chiocca, E. A., & Bronisz, A. (2015). Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro-oncology, 17(5), pp. 652-62. doi:10.1093/neuonc/nou292.
Godlewski J, et al. Belonging to a network--microRNAs, Extracellular Vesicles, and the Glioblastoma Microenvironment. Neuro-oncology. 2015;17(5):652-62. PubMed PMID: 25301812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. AU - Godlewski,Jakub, AU - Krichevsky,Anna M, AU - Johnson,Mark D, AU - Chiocca,E Antonio, AU - Bronisz,Agnieszka, Y1 - 2014/10/09/ PY - 2014/05/04/received PY - 2014/09/09/accepted PY - 2014/10/11/entrez PY - 2014/10/11/pubmed PY - 2015/12/23/medline KW - exosomes KW - extracellular vesicles KW - glioblastoma multiforme KW - microRNA KW - tumor microenvironment SP - 652 EP - 62 JF - Neuro-oncology JO - Neuro-oncology VL - 17 IS - 5 N2 - The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to a unique brain microenvironment and its cellular interactions. Despite extensive evidence of a role for microRNAs in GBM cells, little is known about microRNA-dependent communication between different cellular compartments of the microenvironment that may contribute to the tumor phenotype. While the majority of microRNAs are found intracellularly, a significant number of microRNAs have been observed outside of cells, often encapsulated in secreted extracellular vesicles (EVs). The function of these circulating/secreted microRNAs has not been explored in the context of the brain tumor microenvironment. Establishing how microRNAs are involved in the regulation of oncogenic signaling networks between tumor cells and stroma is likely to add a needed additional layer of complexity to the tumor network, consisting of intercellular communication. More importantly, microRNA/EV signaling may provide an additional therapeutic target for this deadly disease. SN - 1523-5866 UR - https://www.unboundmedicine.com/medline/citation/25301812/Belonging_to_a_network__microRNAs_extracellular_vesicles_and_the_glioblastoma_microenvironment_ L2 - https://academic.oup.com/neuro-oncology/article-lookup/doi/10.1093/neuonc/nou292 DB - PRIME DP - Unbound Medicine ER -