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Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis.
Pediatr Res. 2015 Jan; 77(1-2):127-35.PR

Abstract

The conceptual framework for a gut-brain axis has existed for decades. The Human Microbiome Project is responsible for establishing intestinal dysbiosis as a mediator of inflammatory bowel disease, obesity, and neurodevelopmental disorders in adults. Recent advances in metagenomics implicate gut microbiota and diet as key modulators of the bidirectional signaling pathways between the gut and brain that underlie neurodevelopmental and psychiatric disorders in adults. Evidence linking intestinal dysbiosis to neurodevelopmental disease outcomes in preterm infants is emerging. Recent clinical studies show that intestinal dysbiosis precedes late-onset neonatal sepsis and necrotizing enterocolitis in intensive care nurseries. Moreover, strong epidemiologic evidence links late-onset neonatal sepsis and necrotizing enterocolitis in long-term psychomotor disabilities of very-low-birth-weight infants. The notion of the gut-brain axis thereby supports that intestinal microbiota can indirectly harm the brain of preterm infants. In this review, we highlight the anatomy and physiology of the gut-brain axis and describe transmission of stress signals caused by immune-microbial dysfunction in the gut. These messengers initiate neurologic disease in preterm infants. Understanding neural and humoral signaling through the gut-brain axis will offer insight into therapeutic and dietary approaches that may improve the outcomes of very-low-birth-weight infants.

Authors+Show Affiliations

Department of Child Health, School of Medicine, University of Missouri, Columbia, Missouri.1] Department of Child Health, School of Medicine, University of Missouri, Columbia, Missouri [2] Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri [3] Department of Neurology, School of Medicine, University of Missouri, Columbia, Missouri.Newborn Medicine, Nemours Children's Hospital, Orlando, Florida.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25303278

Citation

Sherman, Michael P., et al. "Gut Microbiota, the Immune System, and Diet Influence the Neonatal Gut-brain Axis." Pediatric Research, vol. 77, no. 1-2, 2015, pp. 127-35.
Sherman MP, Zaghouani H, Niklas V. Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis. Pediatr Res. 2015;77(1-2):127-35.
Sherman, M. P., Zaghouani, H., & Niklas, V. (2015). Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis. Pediatric Research, 77(1-2), 127-35. https://doi.org/10.1038/pr.2014.161
Sherman MP, Zaghouani H, Niklas V. Gut Microbiota, the Immune System, and Diet Influence the Neonatal Gut-brain Axis. Pediatr Res. 2015;77(1-2):127-35. PubMed PMID: 25303278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis. AU - Sherman,Michael P, AU - Zaghouani,Habib, AU - Niklas,Victoria, Y1 - 2014/10/10/ PY - 2014/04/14/received PY - 2014/08/22/accepted PY - 2014/10/11/entrez PY - 2014/10/11/pubmed PY - 2015/9/26/medline SP - 127 EP - 35 JF - Pediatric research JO - Pediatr Res VL - 77 IS - 1-2 N2 - The conceptual framework for a gut-brain axis has existed for decades. The Human Microbiome Project is responsible for establishing intestinal dysbiosis as a mediator of inflammatory bowel disease, obesity, and neurodevelopmental disorders in adults. Recent advances in metagenomics implicate gut microbiota and diet as key modulators of the bidirectional signaling pathways between the gut and brain that underlie neurodevelopmental and psychiatric disorders in adults. Evidence linking intestinal dysbiosis to neurodevelopmental disease outcomes in preterm infants is emerging. Recent clinical studies show that intestinal dysbiosis precedes late-onset neonatal sepsis and necrotizing enterocolitis in intensive care nurseries. Moreover, strong epidemiologic evidence links late-onset neonatal sepsis and necrotizing enterocolitis in long-term psychomotor disabilities of very-low-birth-weight infants. The notion of the gut-brain axis thereby supports that intestinal microbiota can indirectly harm the brain of preterm infants. In this review, we highlight the anatomy and physiology of the gut-brain axis and describe transmission of stress signals caused by immune-microbial dysfunction in the gut. These messengers initiate neurologic disease in preterm infants. Understanding neural and humoral signaling through the gut-brain axis will offer insight into therapeutic and dietary approaches that may improve the outcomes of very-low-birth-weight infants. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/25303278/Gut_microbiota_the_immune_system_and_diet_influence_the_neonatal_gut_brain_axis_ L2 - https://doi.org/10.1038/pr.2014.161 DB - PRIME DP - Unbound Medicine ER -