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Placebo effects in idiopathic and neuropathic pain conditions.
Handb Exp Pharmacol. 2014; 225:121-36.HE

Abstract

The magnitude of placebo analgesia effect appears to be large in chronic pain patients experiencing hyperalgesic states. So far, placebo effects have primarily been investigated in idiopathic pain conditions, such as irritable bowel pain syndrome, but more recently they have also been investigated in neuropathic pain patients, in which the underlying nerve injury is known. Expected pain levels and emotional feelings are central to placebo effects in both types of pain. They appear to help patients to engage in a mindset for pain relief and activate the pain-modulating system. Furthermore, expectations, emotional feelings, and the experience of pain seem to interact over time, thereby maintaining or enhancing the pain-relieving effect. Expectations and emotional feelings also contribute to the effect of active drugs, and recent studies indicate that drug effects and placebo effects interact in ways that may complicate the interpretations of the findings from clinical trials. It is suggested that expectations and emotional feelings may act as additional or alternative measures in the testing of new pharmacological agents, thereby improving the understanding of the interaction between pharmacological effects and placebo effects, which may have far-reaching implications for research and clinical practice.

Authors+Show Affiliations

Department of Psychology and Behavioral Sciences, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark, lenevase@psy.au.dk.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25304529

Citation

Vase, Lene, et al. "Placebo Effects in Idiopathic and Neuropathic Pain Conditions." Handbook of Experimental Pharmacology, vol. 225, 2014, pp. 121-36.
Vase L, Petersen GL, Lund K. Placebo effects in idiopathic and neuropathic pain conditions. Handb Exp Pharmacol. 2014;225:121-36.
Vase, L., Petersen, G. L., & Lund, K. (2014). Placebo effects in idiopathic and neuropathic pain conditions. Handbook of Experimental Pharmacology, 225, 121-36. https://doi.org/10.1007/978-3-662-44519-8_7
Vase L, Petersen GL, Lund K. Placebo Effects in Idiopathic and Neuropathic Pain Conditions. Handb Exp Pharmacol. 2014;225:121-36. PubMed PMID: 25304529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placebo effects in idiopathic and neuropathic pain conditions. AU - Vase,Lene, AU - Petersen,Gitte Laue, AU - Lund,Karen, PY - 2014/10/12/entrez PY - 2014/10/12/pubmed PY - 2015/2/6/medline SP - 121 EP - 36 JF - Handbook of experimental pharmacology JO - Handb Exp Pharmacol VL - 225 N2 - The magnitude of placebo analgesia effect appears to be large in chronic pain patients experiencing hyperalgesic states. So far, placebo effects have primarily been investigated in idiopathic pain conditions, such as irritable bowel pain syndrome, but more recently they have also been investigated in neuropathic pain patients, in which the underlying nerve injury is known. Expected pain levels and emotional feelings are central to placebo effects in both types of pain. They appear to help patients to engage in a mindset for pain relief and activate the pain-modulating system. Furthermore, expectations, emotional feelings, and the experience of pain seem to interact over time, thereby maintaining or enhancing the pain-relieving effect. Expectations and emotional feelings also contribute to the effect of active drugs, and recent studies indicate that drug effects and placebo effects interact in ways that may complicate the interpretations of the findings from clinical trials. It is suggested that expectations and emotional feelings may act as additional or alternative measures in the testing of new pharmacological agents, thereby improving the understanding of the interaction between pharmacological effects and placebo effects, which may have far-reaching implications for research and clinical practice. SN - 0171-2004 UR - https://www.unboundmedicine.com/medline/citation/25304529/Placebo_effects_in_idiopathic_and_neuropathic_pain_conditions_ L2 - https://dx.doi.org/10.1007/978-3-662-44519-8_7 DB - PRIME DP - Unbound Medicine ER -