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Role of recombinant human erythropoietin against mitomycin C-induced cardiac, hepatic and renal dysfunction in Wistar rats.
Hum Exp Toxicol. 2015 May; 34(5):468-78.HE

Abstract

Mitomycin C (MMC) is one of the most effective chemotherapeutic drugs. However, the dose of MMC is greatly limited by its toxicity in normal tissues. Recombinant human erythropoietin (rhEPO), an erythropoietic hormone, has also been shown to exert tissue protective effects. The purpose of this study was to explore the protective effect of rhEPO against MMC-induced heart, liver, and renal dysfunction. Adult male Wistar rats were divided into six groups (with six animals each), namely control, rhEPO alone group, MMC alone group, and rhEPO + MMC group (pre-, co-, and posttreatment conditions). The results showed that MMC induced a marked cardiac, renal, and liver failure characterized by a significant decrease in body weight, organs weight, and organs ratio and a significant increase in creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, and conjugated and total bilirubin levels in serum. Histological examination showed that MMC caused liver alterations. rhEPO treatment restored body weight, organs weight, and organs ratio as well as serum biochemical parameters and histological damage caused by MMC exposure.

Authors+Show Affiliations

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.Department of Nephrology, Dialysis and Transplant, University Hospital of Sahloul, Sousse,Tunisia.Department of Anatomic Pathology and Histology, The University Hospital Farhat Hached, Sousse, Tunisia.Department of Nephrology, Dialysis and Transplant, University Hospital of Sahloul, Sousse,Tunisia.Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia hassen.bacha@fmdm.rnu.tn.Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25304971

Citation

Rjiba-Touati, K, et al. "Role of Recombinant Human Erythropoietin Against Mitomycin C-induced Cardiac, Hepatic and Renal Dysfunction in Wistar Rats." Human & Experimental Toxicology, vol. 34, no. 5, 2015, pp. 468-78.
Rjiba-Touati K, Ayed-Boussema I, Belarbia A, et al. Role of recombinant human erythropoietin against mitomycin C-induced cardiac, hepatic and renal dysfunction in Wistar rats. Hum Exp Toxicol. 2015;34(5):468-78.
Rjiba-Touati, K., Ayed-Boussema, I., Belarbia, A., Mokni, M., Achour, A., Bacha, H., & Abid, S. (2015). Role of recombinant human erythropoietin against mitomycin C-induced cardiac, hepatic and renal dysfunction in Wistar rats. Human & Experimental Toxicology, 34(5), 468-78. https://doi.org/10.1177/0960327114550885
Rjiba-Touati K, et al. Role of Recombinant Human Erythropoietin Against Mitomycin C-induced Cardiac, Hepatic and Renal Dysfunction in Wistar Rats. Hum Exp Toxicol. 2015;34(5):468-78. PubMed PMID: 25304971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of recombinant human erythropoietin against mitomycin C-induced cardiac, hepatic and renal dysfunction in Wistar rats. AU - Rjiba-Touati,K, AU - Ayed-Boussema,I, AU - Belarbia,A, AU - Mokni,M, AU - Achour,A, AU - Bacha,H, AU - Abid,S, Y1 - 2014/10/10/ PY - 2014/10/12/entrez PY - 2014/10/12/pubmed PY - 2016/1/12/medline KW - Mitomycin C KW - chemotherapy KW - heart protection KW - kidney protection KW - liver protection KW - recombinant human erythropoietin SP - 468 EP - 78 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 34 IS - 5 N2 - Mitomycin C (MMC) is one of the most effective chemotherapeutic drugs. However, the dose of MMC is greatly limited by its toxicity in normal tissues. Recombinant human erythropoietin (rhEPO), an erythropoietic hormone, has also been shown to exert tissue protective effects. The purpose of this study was to explore the protective effect of rhEPO against MMC-induced heart, liver, and renal dysfunction. Adult male Wistar rats were divided into six groups (with six animals each), namely control, rhEPO alone group, MMC alone group, and rhEPO + MMC group (pre-, co-, and posttreatment conditions). The results showed that MMC induced a marked cardiac, renal, and liver failure characterized by a significant decrease in body weight, organs weight, and organs ratio and a significant increase in creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, and conjugated and total bilirubin levels in serum. Histological examination showed that MMC caused liver alterations. rhEPO treatment restored body weight, organs weight, and organs ratio as well as serum biochemical parameters and histological damage caused by MMC exposure. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/25304971/Role_of_recombinant_human_erythropoietin_against_mitomycin_C_induced_cardiac_hepatic_and_renal_dysfunction_in_Wistar_rats_ L2 - https://journals.sagepub.com/doi/10.1177/0960327114550885?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -