Tags

Type your tag names separated by a space and hit enter

Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort.
Gastroenterology 2015; 148(1):118-25; quiz e15G

Abstract

BACKGROUND & AIMS

Coffee consumption has been proposed to reduce risk for hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but few data are available from prospective, US multiethnic populations. We evaluated the association of coffee intake with HCC and CLD in 162,022 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the US Multiethnic Cohort (MEC).

METHODS

We collected data from the MEC, a population-based prospective cohort study of >215,000 men and women from Hawaii and California, assembled in 1993-1996. Participants reported coffee consumption and other dietary and lifestyle factors when they joined the study. During an 18-year follow-up period, there were 451 incident cases of HCC and 654 deaths from CLD. Hazard rate ratios (RRs) and 95% confidence intervals (CIs) were calculated using Cox regression, adjusting for known HCC risk factors.

RESULTS

High levels of coffee consumption were associated with reduced risk of incident HCC and CLD mortality (Ptrend ≤ .0002). Compared with non-coffee drinkers, those who drank 2-3 cups per day had a 38% reduction in risk for HCC (RR = 0.62; 95% CI: 0.46-0.84); those who drank ≥4 cups per day had a 41% reduction in HCC risk (RR = 0.59; 95% CI: 0.35-0.99). Compared with non-coffee drinkers, participants who consumed 2-3 cups coffee per day had a 46% reduction in risk of death from CLD (RR = 0.54; 95% CI: 0.42-0.69) and those who drank ≥4 cups per day had a 71% reduction (RR = 0.29; 95% CI: 0.17-0.50). The inverse associations were similar regardless of the participants' ethnicity, sex, body mass index, smoking status, alcohol intake, or diabetes status.

CONCLUSIONS

Increased coffee consumption reduces the risk of HCC and CLD in multiethnic US populations.

Authors+Show Affiliations

Department of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California. Electronic address: vsetiawa@usc.edu.Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.Department of Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25305507

Citation

Setiawan, Veronica Wendy, et al. "Association of Coffee Intake With Reduced Incidence of Liver Cancer and Death From Chronic Liver Disease in the US Multiethnic Cohort." Gastroenterology, vol. 148, no. 1, 2015, pp. 118-25; quiz e15.
Setiawan VW, Wilkens LR, Lu SC, et al. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology. 2015;148(1):118-25; quiz e15.
Setiawan, V. W., Wilkens, L. R., Lu, S. C., Hernandez, B. Y., Le Marchand, L., & Henderson, B. E. (2015). Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology, 148(1), pp. 118-25; quiz e15. doi:10.1053/j.gastro.2014.10.005.
Setiawan VW, et al. Association of Coffee Intake With Reduced Incidence of Liver Cancer and Death From Chronic Liver Disease in the US Multiethnic Cohort. Gastroenterology. 2015;148(1):118-25; quiz e15. PubMed PMID: 25305507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. AU - Setiawan,Veronica Wendy, AU - Wilkens,Lynne R, AU - Lu,Shelly C, AU - Hernandez,Brenda Y, AU - Le Marchand,Loïc, AU - Henderson,Brian E, Y1 - 2014/10/08/ PY - 2014/07/24/received PY - 2014/10/02/revised PY - 2014/10/03/accepted PY - 2014/10/12/entrez PY - 2014/10/12/pubmed PY - 2015/3/7/medline KW - Epidemiology KW - Liver Cancer KW - Protective KW - Race SP - 118-25; quiz e15 JF - Gastroenterology JO - Gastroenterology VL - 148 IS - 1 N2 - BACKGROUND & AIMS: Coffee consumption has been proposed to reduce risk for hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but few data are available from prospective, US multiethnic populations. We evaluated the association of coffee intake with HCC and CLD in 162,022 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the US Multiethnic Cohort (MEC). METHODS: We collected data from the MEC, a population-based prospective cohort study of >215,000 men and women from Hawaii and California, assembled in 1993-1996. Participants reported coffee consumption and other dietary and lifestyle factors when they joined the study. During an 18-year follow-up period, there were 451 incident cases of HCC and 654 deaths from CLD. Hazard rate ratios (RRs) and 95% confidence intervals (CIs) were calculated using Cox regression, adjusting for known HCC risk factors. RESULTS: High levels of coffee consumption were associated with reduced risk of incident HCC and CLD mortality (Ptrend ≤ .0002). Compared with non-coffee drinkers, those who drank 2-3 cups per day had a 38% reduction in risk for HCC (RR = 0.62; 95% CI: 0.46-0.84); those who drank ≥4 cups per day had a 41% reduction in HCC risk (RR = 0.59; 95% CI: 0.35-0.99). Compared with non-coffee drinkers, participants who consumed 2-3 cups coffee per day had a 46% reduction in risk of death from CLD (RR = 0.54; 95% CI: 0.42-0.69) and those who drank ≥4 cups per day had a 71% reduction (RR = 0.29; 95% CI: 0.17-0.50). The inverse associations were similar regardless of the participants' ethnicity, sex, body mass index, smoking status, alcohol intake, or diabetes status. CONCLUSIONS: Increased coffee consumption reduces the risk of HCC and CLD in multiethnic US populations. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/25305507/Association_of_coffee_intake_with_reduced_incidence_of_liver_cancer_and_death_from_chronic_liver_disease_in_the_US_multiethnic_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(14)01200-1 DB - PRIME DP - Unbound Medicine ER -