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[Placental morphology in inherited thrombophilia].
Arkh Patol. 2014 May-Jun; 76(3):33-6.AP

Abstract

OBJECTIVE

To study placental morphological changes in inherited thrombophilia.

SUBJECT AND METHODS

A morphometric method was used to examine placentas from 37 patients divided into 3 groups: 1) 13 pregnant women with verified inherited thrombophilia; 2) 14 pregnant women with inherited thrombophilia and signs of placental inflammatory manifestations (basal deciduitis, intervillositis, placentitis); 3) 10 women with normal pregnancy (a control group).

RESULTS

In inherited thrombophilia, the placentas exhibited morphological manifestations of chronic placental insufficiency as pathological immaturity with a predominance of intermediate differentiated villi and as dissociated maturity of cotyledones, with a substantial reduction in the specialized terminal villi, excessive intervillous fibrinoid formation and villous immuring, evolving pseudoinfarctions, fewer capillaries in the terminal villi, and their increased stromal proportion. At the same time, no significant differences were found in the morphological pattern in inherited thrombophilia concurrent with placental inflammatory changes.

CONCLUSION

In inherited thrombophilia, there is chronic placental insufficiency caused by delayed development of the shaggy chorion.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

25306608

Citation

Drobinskaia, A N., et al. "[Placental Morphology in Inherited Thrombophilia]." Arkhiv Patologii, vol. 76, no. 3, 2014, pp. 33-6.
Drobinskaia AN, Nadeeva AP, Zhukova VA, et al. [Placental morphology in inherited thrombophilia]. Arkh Patol. 2014;76(3):33-6.
Drobinskaia, A. N., Nadeeva, A. P., Zhukova, V. A., Pasman, N. M., Karpov, M. A., & Teliatnikova, N. V. (2014). [Placental morphology in inherited thrombophilia]. Arkhiv Patologii, 76(3), 33-6.
Drobinskaia AN, et al. [Placental Morphology in Inherited Thrombophilia]. Arkh Patol. 2014 May-Jun;76(3):33-6. PubMed PMID: 25306608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Placental morphology in inherited thrombophilia]. AU - Drobinskaia,A N, AU - Nadeeva,A P, AU - Zhukova,V A, AU - Pasman,N M, AU - Karpov,M A, AU - Teliatnikova,N V, PY - 2014/10/14/entrez PY - 2014/10/14/pubmed PY - 2014/12/15/medline SP - 33 EP - 6 JF - Arkhiv patologii JO - Arkh. Patol. VL - 76 IS - 3 N2 - OBJECTIVE: To study placental morphological changes in inherited thrombophilia. SUBJECT AND METHODS: A morphometric method was used to examine placentas from 37 patients divided into 3 groups: 1) 13 pregnant women with verified inherited thrombophilia; 2) 14 pregnant women with inherited thrombophilia and signs of placental inflammatory manifestations (basal deciduitis, intervillositis, placentitis); 3) 10 women with normal pregnancy (a control group). RESULTS: In inherited thrombophilia, the placentas exhibited morphological manifestations of chronic placental insufficiency as pathological immaturity with a predominance of intermediate differentiated villi and as dissociated maturity of cotyledones, with a substantial reduction in the specialized terminal villi, excessive intervillous fibrinoid formation and villous immuring, evolving pseudoinfarctions, fewer capillaries in the terminal villi, and their increased stromal proportion. At the same time, no significant differences were found in the morphological pattern in inherited thrombophilia concurrent with placental inflammatory changes. CONCLUSION: In inherited thrombophilia, there is chronic placental insufficiency caused by delayed development of the shaggy chorion. SN - 0004-1955 UR - https://www.unboundmedicine.com/medline/citation/25306608/[Placental_morphology_in_inherited_thrombophilia]_ L2 - http://www.diseaseinfosearch.org/result/7086 DB - PRIME DP - Unbound Medicine ER -