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Prenatal bisphenol A exposure and maternally reported behavior in boys and girls.
Neurotoxicology. 2014 Dec; 45:91-9.N

Abstract

Prenatal exposure to gonadal hormones plays a major role in the normal development of the male and female brain and sexually dimorphic behaviors. Hormone-dependent differences in brain structure and function suggest that exposure to exogenous endocrine disrupting chemicals may be associated with sex-specific alterations in behavior. Bisphenol A (BPA) is an environmental chemical that has been shown to alter estrogen, androgen, and thyroid hormone signaling pathways. Epidemiological and experimental studies suggest associations between prenatal exposure to BPA and child behavior, however data are inconsistent, and few studies have examined school age children. We examined BPA concentration in spot urine samples from women at mean 27 weeks of pregnancy in relation to child behavior assessed at age 6-10 years using the parent-completed Child Behavior Checklist (CBCL). We report associations between maternal BPA urinary concentrations and several CBCL scores in 153 children (77 boys and 76 girls). We observed a significant interaction between maternal urinary BPA and sex for several behaviors (externalizing, aggression, Anxiety Disorder, Oppositional/Defiant Disorder and Conduct Disorder traits), but no significant associations between BPA and scores on any CBCL scales. However in analyses restricted to children of mothers with detectable prenatal urinary BPA (n=125), BPA was associated with moderately increased internalizing and externalizing behaviors, withdrawn/depressed behavior, somatic problems, and Oppositional/Defiant Disorder traits in boys. In addition we observed a significant interaction between BPA and sex for several behaviors (externalizing, withdrawn/depressed, rule-breaking, Oppositional/Defiant Disorder traits, and Conduct Disorder traits). These results suggest that prenatal exposure to BPA may be related to increased behavior problems in school age boys, but not girls.

Authors+Show Affiliations

Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: sarah.evans@mssm.edu.Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States.Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25307304

Citation

Evans, Sarah F., et al. "Prenatal Bisphenol a Exposure and Maternally Reported Behavior in Boys and Girls." Neurotoxicology, vol. 45, 2014, pp. 91-9.
Evans SF, Kobrosly RW, Barrett ES, et al. Prenatal bisphenol A exposure and maternally reported behavior in boys and girls. Neurotoxicology. 2014;45:91-9.
Evans, S. F., Kobrosly, R. W., Barrett, E. S., Thurston, S. W., Calafat, A. M., Weiss, B., Stahlhut, R., Yolton, K., & Swan, S. H. (2014). Prenatal bisphenol A exposure and maternally reported behavior in boys and girls. Neurotoxicology, 45, 91-9. https://doi.org/10.1016/j.neuro.2014.10.003
Evans SF, et al. Prenatal Bisphenol a Exposure and Maternally Reported Behavior in Boys and Girls. Neurotoxicology. 2014;45:91-9. PubMed PMID: 25307304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal bisphenol A exposure and maternally reported behavior in boys and girls. AU - Evans,Sarah F, AU - Kobrosly,Roni W, AU - Barrett,Emily S, AU - Thurston,Sally W, AU - Calafat,Antonia M, AU - Weiss,Bernard, AU - Stahlhut,Richard, AU - Yolton,Kimberly, AU - Swan,Shanna H, Y1 - 2014/10/13/ PY - 2014/05/30/received PY - 2014/09/25/revised PY - 2014/10/01/accepted PY - 2014/10/14/entrez PY - 2014/10/14/pubmed PY - 2015/10/16/medline KW - Bisphenol A KW - Child behavior problems KW - Children KW - Epidemiology SP - 91 EP - 9 JF - Neurotoxicology JO - Neurotoxicology VL - 45 N2 - Prenatal exposure to gonadal hormones plays a major role in the normal development of the male and female brain and sexually dimorphic behaviors. Hormone-dependent differences in brain structure and function suggest that exposure to exogenous endocrine disrupting chemicals may be associated with sex-specific alterations in behavior. Bisphenol A (BPA) is an environmental chemical that has been shown to alter estrogen, androgen, and thyroid hormone signaling pathways. Epidemiological and experimental studies suggest associations between prenatal exposure to BPA and child behavior, however data are inconsistent, and few studies have examined school age children. We examined BPA concentration in spot urine samples from women at mean 27 weeks of pregnancy in relation to child behavior assessed at age 6-10 years using the parent-completed Child Behavior Checklist (CBCL). We report associations between maternal BPA urinary concentrations and several CBCL scores in 153 children (77 boys and 76 girls). We observed a significant interaction between maternal urinary BPA and sex for several behaviors (externalizing, aggression, Anxiety Disorder, Oppositional/Defiant Disorder and Conduct Disorder traits), but no significant associations between BPA and scores on any CBCL scales. However in analyses restricted to children of mothers with detectable prenatal urinary BPA (n=125), BPA was associated with moderately increased internalizing and externalizing behaviors, withdrawn/depressed behavior, somatic problems, and Oppositional/Defiant Disorder traits in boys. In addition we observed a significant interaction between BPA and sex for several behaviors (externalizing, withdrawn/depressed, rule-breaking, Oppositional/Defiant Disorder traits, and Conduct Disorder traits). These results suggest that prenatal exposure to BPA may be related to increased behavior problems in school age boys, but not girls. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/25307304/Prenatal_bisphenol_A_exposure_and_maternally_reported_behavior_in_boys_and_girls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(14)00171-5 DB - PRIME DP - Unbound Medicine ER -