Tags

Type your tag names separated by a space and hit enter

Meningococcal serogroup A, C, W, and Y serum bactericidal antibody profiles in Hajj pilgrims.
Int J Infect Dis. 2014 Nov; 28:171-5.IJ

Abstract

BACKGROUND

The religious seasons of Hajj and Umra in the Kingdom of Saudi Arabia (KSA) have historically been associated with epidemics of meningococcal disease. Due to the effective preventive measures taken in recent years, including vaccination, no meningococcal outbreaks have been reported during Hajj or were Hajj-associated. However, little is known about the immunological profile of pilgrims. The aim of this study was to assess the immunological profile of pilgrims on arrival in KSA against the four meningococcal serogroups, A, C, W, and Y, contained within the quadrivalent vaccine.

METHODS

Following consent, socio-demographic factors and health-related information was collected from pilgrims arriving at King Abdul Aziz International Airport and a blood sample taken. Antibodies were quantified by serum bactericidal antibody assay using baby rabbit complement (rSBA) against the four meningococcal serogroups, A, C, W, and Y.

RESULTS

Serum samples were collected from 796 pilgrims; rSBA results were obtained for all four serogroups for 741 of these samples. A total of 48 (6.5%) Hajjis had previously attended Hajj, ranging from 1 to 14 times (median 2 times); 98.2% had received meningococcal quadrivalent vaccine in the last 3 years. Of the 13 who had not, all originated from Bangladesh, with four reporting no previous meningococcal vaccination and nine reporting having received the vaccination more than 3 years ago. For serogroup A, only one pilgrim from Indonesia had an rSBA titre <8. For serogroups C, W, and Y, the percentages of pilgrims with rSBA titres <8 were 9.9%, 17.4%, and 9.4%, respectively. Of note was the high prevalence of non-complement-mediated lysis in pilgrims originating from Nigeria (28/47; 59.6%) and Afghanistan (21/47; 44.7%), but not the other countries. This may be a reflection of the type and pattern of antibiotic usage among these communities.

CONCLUSION

The vast majority of pilgrims are vaccinated and protected against meningococcal serogroups A, C, W, and Y.

Authors+Show Affiliations

Global Centre for Mass Gatherings Medicine (GCMGM), Ministry of Health, Riyadh, Kingdom of Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia. Electronic address: zmemish@yahoo.com.Global Centre for Mass Gatherings Medicine (GCMGM), Ministry of Health, Riyadh, Kingdom of Saudi Arabia.Global Centre for Mass Gatherings Medicine (GCMGM), Ministry of Health, Riyadh, Kingdom of Saudi Arabia.Global Centre for Mass Gatherings Medicine (GCMGM), Ministry of Health, Riyadh, Kingdom of Saudi Arabia.Makkah Regional Health Affairs, Ministry of Health, Makkah, Kingdom of Saudi Arabia.Vaccine Evaluation Unit, Public Health England, Manchester Royal Infirmary, Manchester, UK.Vaccine Evaluation Unit, Public Health England, Manchester Royal Infirmary, Manchester, UK.Vaccine Evaluation Unit, Public Health England, Manchester Royal Infirmary, Manchester, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25307887

Citation

Memish, Ziad A., et al. "Meningococcal Serogroup A, C, W, and Y Serum Bactericidal Antibody Profiles in Hajj Pilgrims." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 28, 2014, pp. 171-5.
Memish ZA, Yezli S, Almasri M, et al. Meningococcal serogroup A, C, W, and Y serum bactericidal antibody profiles in Hajj pilgrims. Int J Infect Dis. 2014;28:171-5.
Memish, Z. A., Yezli, S., Almasri, M., Assiri, A., Turkestani, A., Findlow, H., Bai, X., & Borrow, R. (2014). Meningococcal serogroup A, C, W, and Y serum bactericidal antibody profiles in Hajj pilgrims. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 28, 171-5. https://doi.org/10.1016/j.ijid.2014.09.005
Memish ZA, et al. Meningococcal Serogroup A, C, W, and Y Serum Bactericidal Antibody Profiles in Hajj Pilgrims. Int J Infect Dis. 2014;28:171-5. PubMed PMID: 25307887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meningococcal serogroup A, C, W, and Y serum bactericidal antibody profiles in Hajj pilgrims. AU - Memish,Ziad A, AU - Yezli,Saber, AU - Almasri,Malak, AU - Assiri,Abdullah, AU - Turkestani,Abdulhafeez, AU - Findlow,Helen, AU - Bai,Xilian, AU - Borrow,Ray, Y1 - 2014/10/12/ PY - 2014/09/09/received PY - 2014/09/17/accepted PY - 2014/10/14/entrez PY - 2014/10/14/pubmed PY - 2015/12/15/medline KW - Hajj KW - Meningococcal KW - Pilgrimage KW - Serum bactericidal antibody KW - Vaccine SP - 171 EP - 5 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 28 N2 - BACKGROUND: The religious seasons of Hajj and Umra in the Kingdom of Saudi Arabia (KSA) have historically been associated with epidemics of meningococcal disease. Due to the effective preventive measures taken in recent years, including vaccination, no meningococcal outbreaks have been reported during Hajj or were Hajj-associated. However, little is known about the immunological profile of pilgrims. The aim of this study was to assess the immunological profile of pilgrims on arrival in KSA against the four meningococcal serogroups, A, C, W, and Y, contained within the quadrivalent vaccine. METHODS: Following consent, socio-demographic factors and health-related information was collected from pilgrims arriving at King Abdul Aziz International Airport and a blood sample taken. Antibodies were quantified by serum bactericidal antibody assay using baby rabbit complement (rSBA) against the four meningococcal serogroups, A, C, W, and Y. RESULTS: Serum samples were collected from 796 pilgrims; rSBA results were obtained for all four serogroups for 741 of these samples. A total of 48 (6.5%) Hajjis had previously attended Hajj, ranging from 1 to 14 times (median 2 times); 98.2% had received meningococcal quadrivalent vaccine in the last 3 years. Of the 13 who had not, all originated from Bangladesh, with four reporting no previous meningococcal vaccination and nine reporting having received the vaccination more than 3 years ago. For serogroup A, only one pilgrim from Indonesia had an rSBA titre <8. For serogroups C, W, and Y, the percentages of pilgrims with rSBA titres <8 were 9.9%, 17.4%, and 9.4%, respectively. Of note was the high prevalence of non-complement-mediated lysis in pilgrims originating from Nigeria (28/47; 59.6%) and Afghanistan (21/47; 44.7%), but not the other countries. This may be a reflection of the type and pattern of antibiotic usage among these communities. CONCLUSION: The vast majority of pilgrims are vaccinated and protected against meningococcal serogroups A, C, W, and Y. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/25307887/Meningococcal_serogroup_A_C_W_and_Y_serum_bactericidal_antibody_profiles_in_Hajj_pilgrims_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(14)01629-4 DB - PRIME DP - Unbound Medicine ER -