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7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease.
Mov Disord. 2014 Nov; 29(13):1574-81.MD

Abstract

A hallmark of Parkinson's disease (PD) is the progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Dopaminergic denervation is commonly imaged using radiotracer imaging in target structures such as the striatum. Until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia nigra (SN) directly. Histologically, the SN is subdivided into the ventral pars reticulata and the dorsal pars compacta, which is composed of dopaminergic neurons. In humans, dopaminergic neurons, which are known to accumulate neuromelanin, form clusters of cells (nigrosomes) that penetrate deep into the SN pars reticulata (SNr). The SNr contains higher levels of iron than the SNc in normal subjects. Neuromelanin and T2*-weighted imaging therefore better detect the SNc and the SNr, respectively. The development of ultra-high field 7 Tesla (7T) magnetic resonance imaging (MRI) provided the increase in spatial resolution and in contrast that was needed to detect changes in SN morphology. 7T MRI allows visualization of nigrosome-1 as a hyperintense signal area on T2*-weighted images in the SNc of healthy subjects and its absence in PD patients, probably because of the loss of melanized neurons and the increase of iron deposition. This review is designed to provide a better understanding of the correspondence between the outlines and subdivisions of the SN detected using different MRI contrasts and the histological organization of the SN. The recent findings obtained at 7T will then be presented in relation to histological knowledge.

Authors+Show Affiliations

Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; ICM Team Control of Normal and Abnormal Movement; Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25308960

Citation

Lehéricy, Stéphane, et al. "7 Tesla Magnetic Resonance Imaging: a Closer Look at Substantia Nigra Anatomy in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 29, no. 13, 2014, pp. 1574-81.
Lehéricy S, Bardinet E, Poupon C, et al. 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease. Mov Disord. 2014;29(13):1574-81.
Lehéricy, S., Bardinet, E., Poupon, C., Vidailhet, M., & François, C. (2014). 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 29(13), 1574-81. https://doi.org/10.1002/mds.26043
Lehéricy S, et al. 7 Tesla Magnetic Resonance Imaging: a Closer Look at Substantia Nigra Anatomy in Parkinson's Disease. Mov Disord. 2014;29(13):1574-81. PubMed PMID: 25308960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease. AU - Lehéricy,Stéphane, AU - Bardinet,Eric, AU - Poupon,Cyril, AU - Vidailhet,Marie, AU - François,Chantal, Y1 - 2014/10/12/ PY - 2014/06/14/received PY - 2014/08/09/revised PY - 2014/08/17/accepted PY - 2014/10/14/entrez PY - 2014/10/14/pubmed PY - 2015/6/24/medline KW - iron KW - neuromelanin KW - nigrosome KW - substantia nigra pars compacta KW - substantia nigra pars reticulata SP - 1574 EP - 81 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 29 IS - 13 N2 - A hallmark of Parkinson's disease (PD) is the progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Dopaminergic denervation is commonly imaged using radiotracer imaging in target structures such as the striatum. Until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia nigra (SN) directly. Histologically, the SN is subdivided into the ventral pars reticulata and the dorsal pars compacta, which is composed of dopaminergic neurons. In humans, dopaminergic neurons, which are known to accumulate neuromelanin, form clusters of cells (nigrosomes) that penetrate deep into the SN pars reticulata (SNr). The SNr contains higher levels of iron than the SNc in normal subjects. Neuromelanin and T2*-weighted imaging therefore better detect the SNc and the SNr, respectively. The development of ultra-high field 7 Tesla (7T) magnetic resonance imaging (MRI) provided the increase in spatial resolution and in contrast that was needed to detect changes in SN morphology. 7T MRI allows visualization of nigrosome-1 as a hyperintense signal area on T2*-weighted images in the SNc of healthy subjects and its absence in PD patients, probably because of the loss of melanized neurons and the increase of iron deposition. This review is designed to provide a better understanding of the correspondence between the outlines and subdivisions of the SN detected using different MRI contrasts and the histological organization of the SN. The recent findings obtained at 7T will then be presented in relation to histological knowledge. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/25308960/7_Tesla_magnetic_resonance_imaging:_a_closer_look_at_substantia_nigra_anatomy_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.26043 DB - PRIME DP - Unbound Medicine ER -