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Vitamin D and pregnancy outcomes.
Curr Opin Obstet Gynecol. 2014 Dec; 26(6):438-47.CO

Abstract

PURPOSE OF REVIEW

This article presents an overview of the most recent scientific evidence of the role of maternal vitamin D on pregnancy outcomes, with a particular emphasis on those articles in the English-language literature published between 1 January 2013 and 1 July 2014 in PubMed.

RECENT FINDINGS

Low levels of vitamin D status, as measured by 25-hydroxyvitamin D [25(OH)D], are common in pregnant women. Meta-analysis of observational studies has demonstrated positive associations between vitamin D status and adverse pregnancy outcomes such as preeclampsia, gestational diabetes mellitus, preterm birth and small-for-gestational age. There was heterogeneity among studies in terms of design, population, geographic location, definitions of exposure and outcome, gestational age at sampling, confounding factors and approach to analyses. Randomized controlled trials (RCTs) indicate that vitamin D supplementation during pregnancy optimizes maternal and neonatal vitamin D status.

SUMMARY

Recent evidence supports that low maternal vitamin D status is associated with an increased risk of adverse pregnancy outcomes. Interventional studies demonstrate that vitamin D supplementation during pregnancy optimizes maternal and neonatal vitamin D status. Large, well designed, multicentre RCTs are required to determine whether vitamin D supplementation in pregnant women with low vitamin D status reduces the risk of adverse pregnancy outcomes.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Saint-Justine Hospital, University of Montreal, Montreal, Quebec, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25310531

Citation

Wei, Shu Qin. "Vitamin D and Pregnancy Outcomes." Current Opinion in Obstetrics & Gynecology, vol. 26, no. 6, 2014, pp. 438-47.
Wei SQ. Vitamin D and pregnancy outcomes. Curr Opin Obstet Gynecol. 2014;26(6):438-47.
Wei, S. Q. (2014). Vitamin D and pregnancy outcomes. Current Opinion in Obstetrics & Gynecology, 26(6), 438-47. https://doi.org/10.1097/GCO.0000000000000117
Wei SQ. Vitamin D and Pregnancy Outcomes. Curr Opin Obstet Gynecol. 2014;26(6):438-47. PubMed PMID: 25310531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and pregnancy outcomes. A1 - Wei,Shu Qin, PY - 2014/10/14/entrez PY - 2014/10/14/pubmed PY - 2015/7/2/medline SP - 438 EP - 47 JF - Current opinion in obstetrics & gynecology JO - Curr Opin Obstet Gynecol VL - 26 IS - 6 N2 - PURPOSE OF REVIEW: This article presents an overview of the most recent scientific evidence of the role of maternal vitamin D on pregnancy outcomes, with a particular emphasis on those articles in the English-language literature published between 1 January 2013 and 1 July 2014 in PubMed. RECENT FINDINGS: Low levels of vitamin D status, as measured by 25-hydroxyvitamin D [25(OH)D], are common in pregnant women. Meta-analysis of observational studies has demonstrated positive associations between vitamin D status and adverse pregnancy outcomes such as preeclampsia, gestational diabetes mellitus, preterm birth and small-for-gestational age. There was heterogeneity among studies in terms of design, population, geographic location, definitions of exposure and outcome, gestational age at sampling, confounding factors and approach to analyses. Randomized controlled trials (RCTs) indicate that vitamin D supplementation during pregnancy optimizes maternal and neonatal vitamin D status. SUMMARY: Recent evidence supports that low maternal vitamin D status is associated with an increased risk of adverse pregnancy outcomes. Interventional studies demonstrate that vitamin D supplementation during pregnancy optimizes maternal and neonatal vitamin D status. Large, well designed, multicentre RCTs are required to determine whether vitamin D supplementation in pregnant women with low vitamin D status reduces the risk of adverse pregnancy outcomes. SN - 1473-656X UR - https://www.unboundmedicine.com/medline/citation/25310531/Vitamin_D_and_pregnancy_outcomes_ L2 - https://doi.org/10.1097/GCO.0000000000000117 DB - PRIME DP - Unbound Medicine ER -