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Vascular hippocampal plasticity after aerobic exercise in older adults.

Abstract

Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical region for recall and recognition memory. In a mechanistic proof-of-concept intervention over 3 months, we investigated whether healthy older adults (60-77 years) also show such plasticity. Regional cerebral blood flow (rCBF) and volume (rCBV) were measured with gadolinium-based perfusion imaging (3 Tesla magnetic resonance image (MRI)). Hippocampal volumes were assessed by high-resolution 7 Tesla MRI. Fitness improvement correlated with changes in hippocampal perfusion and hippocampal head volume. Perfusion tended to increase in younger, but to decrease in older individuals. The changes in fitness, hippocampal perfusion and volume were positively related to changes in recognition memory and early recall for complex spatial objects. Path analyses indicated that fitness-related changes in complex object recognition were modulated by hippocampal perfusion. These findings indicate a preserved capacity of the aging human hippocampus for functionally relevant vascular plasticity, which decreases with progressing age.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    1] Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany [2] German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany.

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    Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.

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    German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany.

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    German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany.

    ,

    German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany.

    ,

    German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany.

    ,

    1] Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany [2] Aging Research Center, Karolinska Institute, Stockholm, Sweden.

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    Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.

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    Aging Research Center, Karolinska Institute, Stockholm, Sweden.

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    Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.

    ,

    Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.

    ,

    1] German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany [2] Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany [3] Leibniz Institute for Neurobiology, Magdeburg, Germany.

    ,

    1] German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany [2] Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.

    1] Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany [2] German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany [3] Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany [4] Institute of Cognitive Neuroscience, University College London, London, UK.

    Source

    Molecular psychiatry 20:5 2015 May pg 585-93

    MeSH

    Aged
    Analysis of Variance
    Cerebrovascular Circulation
    Cognition
    Exercise
    Female
    Gadolinium
    Hippocampus
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Mental Recall
    Middle Aged
    Neuropsychological Tests
    Oxygen Consumption
    Statistics as Topic
    Verbal Learning

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25311366

    Citation

    Maass, A, et al. "Vascular Hippocampal Plasticity After Aerobic Exercise in Older Adults." Molecular Psychiatry, vol. 20, no. 5, 2015, pp. 585-93.
    Maass A, Düzel S, Goerke M, et al. Vascular hippocampal plasticity after aerobic exercise in older adults. Mol Psychiatry. 2015;20(5):585-93.
    Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., ... Düzel, E. (2015). Vascular hippocampal plasticity after aerobic exercise in older adults. Molecular Psychiatry, 20(5), pp. 585-93. doi:10.1038/mp.2014.114.
    Maass A, et al. Vascular Hippocampal Plasticity After Aerobic Exercise in Older Adults. Mol Psychiatry. 2015;20(5):585-93. PubMed PMID: 25311366.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vascular hippocampal plasticity after aerobic exercise in older adults. AU - Maass,A, AU - Düzel,S, AU - Goerke,M, AU - Becke,A, AU - Sobieray,U, AU - Neumann,K, AU - Lövden,M, AU - Lindenberger,U, AU - Bäckman,L, AU - Braun-Dullaeus,R, AU - Ahrens,D, AU - Heinze,H-J, AU - Müller,N G, AU - Düzel,E, Y1 - 2014/10/14/ PY - 2014/01/14/received PY - 2014/08/07/revised PY - 2014/08/21/accepted PY - 2014/10/15/entrez PY - 2014/10/15/pubmed PY - 2016/1/20/medline SP - 585 EP - 93 JF - Molecular psychiatry JO - Mol. Psychiatry VL - 20 IS - 5 N2 - Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical region for recall and recognition memory. In a mechanistic proof-of-concept intervention over 3 months, we investigated whether healthy older adults (60-77 years) also show such plasticity. Regional cerebral blood flow (rCBF) and volume (rCBV) were measured with gadolinium-based perfusion imaging (3 Tesla magnetic resonance image (MRI)). Hippocampal volumes were assessed by high-resolution 7 Tesla MRI. Fitness improvement correlated with changes in hippocampal perfusion and hippocampal head volume. Perfusion tended to increase in younger, but to decrease in older individuals. The changes in fitness, hippocampal perfusion and volume were positively related to changes in recognition memory and early recall for complex spatial objects. Path analyses indicated that fitness-related changes in complex object recognition were modulated by hippocampal perfusion. These findings indicate a preserved capacity of the aging human hippocampus for functionally relevant vascular plasticity, which decreases with progressing age. SN - 1476-5578 UR - https://www.unboundmedicine.com/medline/citation/25311366/Vascular_hippocampal_plasticity_after_aerobic_exercise_in_older_adults_ L2 - http://dx.doi.org/10.1038/mp.2014.114 DB - PRIME DP - Unbound Medicine ER -