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Red meat intake, insulin resistance, and markers of endothelial function among Iranian women.
Mol Nutr Food Res 2015; 59(2):315-22MN

Abstract

SCOPE

Few data, with conflicting findings, are available linking red meat consumption to indicators of insulin resistance and endothelial dysfunction. This study aimed to investigate the association of red meat consumption with insulin resistance and endothelial dysfunction among a sample of female nurses in Isfahan, Iran.

METHODS AND RESULTS

This cross-sectional study was carried out among 420 female nurses who were selected by a multistage cluster random sampling method. Usual dietary intakes were assessed using a validated food frequency questionnaire. Red meat intake was calculated by summing up the consumption of all kinds of red meat in foods and processed meat in sausages and fast foods. To measure serum concentrations of adhesion molecules and glycemic indexes, a fasting blood sample was taken. After adjustment for potential confounders, high red meat intake was significantly associated with higher fasting plasma glucose, homeostasis model assessment of insulin resistance, and lower quantitative insulin sensitivity check index. Although high red meat intake was significantly associated with higher serum insulin levels and lower homeostasis model assessment of beta-cell function in the crude model, after controlling for BMI, the association was no longer significant. Red meat consumption was associated with high concentrations of E-selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble intercellular adhesion molecule-1 (sICAM-1) after adjustment for different potential confounders.

CONCLUSION

We found that increased red meat intake was associated with high concentrations of plasma endothelial dysfunction biomarkers and abnormal glucose homeostasis among Iranian women. Prospective studies are required to confirm these findings.

Authors+Show Affiliations

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25312838

Citation

Barak, Farzaneh, et al. "Red Meat Intake, Insulin Resistance, and Markers of Endothelial Function Among Iranian Women." Molecular Nutrition & Food Research, vol. 59, no. 2, 2015, pp. 315-22.
Barak F, Falahi E, Keshteli AH, et al. Red meat intake, insulin resistance, and markers of endothelial function among Iranian women. Mol Nutr Food Res. 2015;59(2):315-22.
Barak, F., Falahi, E., Keshteli, A. H., Yazdannik, A., Saneei, P., & Esmaillzadeh, A. (2015). Red meat intake, insulin resistance, and markers of endothelial function among Iranian women. Molecular Nutrition & Food Research, 59(2), pp. 315-22. doi:10.1002/mnfr.201400333.
Barak F, et al. Red Meat Intake, Insulin Resistance, and Markers of Endothelial Function Among Iranian Women. Mol Nutr Food Res. 2015;59(2):315-22. PubMed PMID: 25312838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red meat intake, insulin resistance, and markers of endothelial function among Iranian women. AU - Barak,Farzaneh, AU - Falahi,Ebrahim, AU - Keshteli,Ammar Hassanzadeh, AU - Yazdannik,Ahmadreza, AU - Saneei,Parvane, AU - Esmaillzadeh,Ahmad, Y1 - 2014/11/17/ PY - 2014/05/16/received PY - 2014/09/29/revised PY - 2014/10/06/accepted PY - 2014/10/15/entrez PY - 2014/10/15/pubmed PY - 2015/10/10/medline KW - Endothelial function KW - Insulin resistance KW - Red meat SP - 315 EP - 22 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 59 IS - 2 N2 - SCOPE: Few data, with conflicting findings, are available linking red meat consumption to indicators of insulin resistance and endothelial dysfunction. This study aimed to investigate the association of red meat consumption with insulin resistance and endothelial dysfunction among a sample of female nurses in Isfahan, Iran. METHODS AND RESULTS: This cross-sectional study was carried out among 420 female nurses who were selected by a multistage cluster random sampling method. Usual dietary intakes were assessed using a validated food frequency questionnaire. Red meat intake was calculated by summing up the consumption of all kinds of red meat in foods and processed meat in sausages and fast foods. To measure serum concentrations of adhesion molecules and glycemic indexes, a fasting blood sample was taken. After adjustment for potential confounders, high red meat intake was significantly associated with higher fasting plasma glucose, homeostasis model assessment of insulin resistance, and lower quantitative insulin sensitivity check index. Although high red meat intake was significantly associated with higher serum insulin levels and lower homeostasis model assessment of beta-cell function in the crude model, after controlling for BMI, the association was no longer significant. Red meat consumption was associated with high concentrations of E-selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble intercellular adhesion molecule-1 (sICAM-1) after adjustment for different potential confounders. CONCLUSION: We found that increased red meat intake was associated with high concentrations of plasma endothelial dysfunction biomarkers and abnormal glucose homeostasis among Iranian women. Prospective studies are required to confirm these findings. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/25312838/Red_meat_intake_insulin_resistance_and_markers_of_endothelial_function_among_Iranian_women_ L2 - https://doi.org/10.1002/mnfr.201400333 DB - PRIME DP - Unbound Medicine ER -