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The acute satellite cell response and skeletal muscle hypertrophy following resistance training.
PLoS One. 2014; 9(10):e109739.Plos

Abstract

The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy. Twenty-three males (aged 18-35 yrs) participated in 16 wk of progressive, whole body resistance training, resulting in changes of 7.9±1.6% (range of -1.9-24.7%) and 21.0±4.0% (range of -7.0 to 51.7%) in quadriceps volume and myofibre cross-sectional area (CSA), respectively. The SC response to a single bout of resistance exercise (80% 1RM), analyzed via immunofluorescent staining resulted in an expansion of type II fibre associated SC 72 h following exercise (pre: 11.3±0.9; 72 h: 14.8±1.4 SC/type II fibre; p<0.05). Training resulted in an expansion of the SC pool associated with type I (pre: 10.7±1.1; post: 12.1±1.2 SC/type I fibre; p<0.05) and type II fibres (pre: 11.3±0.9; post: 13.0±1.2 SC/type II fibre; p<0.05). Analysis of individual SC responses revealed a correlation between the relative change in type I associated SC 24 to 72 hours following an acute bout of resistance exercise and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.566, p = 0.012) and the relative change in type II associated SC following 16 weeks of resistance training and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.493, p = 0.027). Our results suggest that the SC response to resistance exercise is related to the extent of muscular hypertrophy induced by training.

Authors+Show Affiliations

Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, McMaster University, Hamilton, Ontario, Canada.Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada; Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25313863

Citation

Bellamy, Leeann M., et al. "The Acute Satellite Cell Response and Skeletal Muscle Hypertrophy Following Resistance Training." PloS One, vol. 9, no. 10, 2014, pp. e109739.
Bellamy LM, Joanisse S, Grubb A, et al. The acute satellite cell response and skeletal muscle hypertrophy following resistance training. PLoS One. 2014;9(10):e109739.
Bellamy, L. M., Joanisse, S., Grubb, A., Mitchell, C. J., McKay, B. R., Phillips, S. M., Baker, S., & Parise, G. (2014). The acute satellite cell response and skeletal muscle hypertrophy following resistance training. PloS One, 9(10), e109739. https://doi.org/10.1371/journal.pone.0109739
Bellamy LM, et al. The Acute Satellite Cell Response and Skeletal Muscle Hypertrophy Following Resistance Training. PLoS One. 2014;9(10):e109739. PubMed PMID: 25313863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The acute satellite cell response and skeletal muscle hypertrophy following resistance training. AU - Bellamy,Leeann M, AU - Joanisse,Sophie, AU - Grubb,Amanda, AU - Mitchell,Cameron J, AU - McKay,Bryon R, AU - Phillips,Stuart M, AU - Baker,Steven, AU - Parise,Gianni, Y1 - 2014/10/14/ PY - 2014/06/19/received PY - 2014/09/02/accepted PY - 2014/10/15/entrez PY - 2014/10/15/pubmed PY - 2015/6/24/medline SP - e109739 EP - e109739 JF - PloS one JO - PLoS One VL - 9 IS - 10 N2 - The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy. Twenty-three males (aged 18-35 yrs) participated in 16 wk of progressive, whole body resistance training, resulting in changes of 7.9±1.6% (range of -1.9-24.7%) and 21.0±4.0% (range of -7.0 to 51.7%) in quadriceps volume and myofibre cross-sectional area (CSA), respectively. The SC response to a single bout of resistance exercise (80% 1RM), analyzed via immunofluorescent staining resulted in an expansion of type II fibre associated SC 72 h following exercise (pre: 11.3±0.9; 72 h: 14.8±1.4 SC/type II fibre; p<0.05). Training resulted in an expansion of the SC pool associated with type I (pre: 10.7±1.1; post: 12.1±1.2 SC/type I fibre; p<0.05) and type II fibres (pre: 11.3±0.9; post: 13.0±1.2 SC/type II fibre; p<0.05). Analysis of individual SC responses revealed a correlation between the relative change in type I associated SC 24 to 72 hours following an acute bout of resistance exercise and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.566, p = 0.012) and the relative change in type II associated SC following 16 weeks of resistance training and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.493, p = 0.027). Our results suggest that the SC response to resistance exercise is related to the extent of muscular hypertrophy induced by training. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25313863/The_acute_satellite_cell_response_and_skeletal_muscle_hypertrophy_following_resistance_training_ L2 - https://dx.plos.org/10.1371/journal.pone.0109739 DB - PRIME DP - Unbound Medicine ER -