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Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan.
PLoS One. 2014; 9(10):e110270.Plos

Abstract

INTRODUCTION

Previous studies have suggested that estrogens play a role in the development of ulcerative colitis (UC). Because isoflavones have a similar structure to 17β-estradiol, dietary consumption of isoflavones may have similar influences on the development of UC. We examined the association between pre-illness isoflavone consumption and the risk of UC.

MATERIALS AND METHODS

We conducted a hospital-based case control study, and compared the dietary habits of 126 newly diagnosed UC cases with those of 170 age- and gender-matched hospital controls. Information on dietary factors was collected using a self-administered diet history questionnaire. To consider potential changes in dietary habits due to disease symptoms, the habits were assessed separately during the previous 1 month and at 1 year before the recruitment.

RESULTS

In the assessment of dietary habits during the previous 1 month, the highest tertile of isoflavone consumption revealed an increased odds ratio (OR) for UC (OR = 2.79; 95% confidence interval (CI), 1.39-5.59; Trend P = 0.004). A significant association was also observed for the dietary assessment at 1 year before, when most UC cases had not yet experienced their first disease symptoms (OR = 2.06; 95% CI, 1.05-4.04; Trend P = 0.04). Associations were more pronounced in females (OR in highest tertile of isoflavone consumption at 1 year before = 4.76; 95% CI, 1.30-17.5; Trend P = 0.02) but were obscured in males (corresponding OR = 1.21; 95% CI, 0.49-3.01; Trend P = 0.63).

CONCLUSIONS

Dietary isoflavone consumption may be associated with an increased risk of UC, particularly in females. Prospective cohort studies are warranted to confirm these findings.

Authors+Show Affiliations

Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan.Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan.Department of Gastroenterology, Osaka City University Faculty of Medicine, Osaka, Japan.Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.Department of Gastroenterology, Osaka City University Faculty of Medicine, Osaka, Japan.Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan; Clinical Epidemiology Research Center, Medical Co. LTA, Fukuoka, Japan.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25314032

Citation

Ohfuji, Satoko, et al. "Pre-illness Isoflavone Consumption and Disease Risk of Ulcerative Colitis: a Multicenter Case-control Study in Japan." PloS One, vol. 9, no. 10, 2014, pp. e110270.
Ohfuji S, Fukushima W, Watanabe K, et al. Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan. PLoS One. 2014;9(10):e110270.
Ohfuji, S., Fukushima, W., Watanabe, K., Sasaki, S., Yamagami, H., Nagahori, M., Watanabe, M., & Hirota, Y. (2014). Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan. PloS One, 9(10), e110270. https://doi.org/10.1371/journal.pone.0110270
Ohfuji S, et al. Pre-illness Isoflavone Consumption and Disease Risk of Ulcerative Colitis: a Multicenter Case-control Study in Japan. PLoS One. 2014;9(10):e110270. PubMed PMID: 25314032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan. AU - Ohfuji,Satoko, AU - Fukushima,Wakaba, AU - Watanabe,Kenji, AU - Sasaki,Satoshi, AU - Yamagami,Hirokazu, AU - Nagahori,Masakazu, AU - Watanabe,Mamoru, AU - Hirota,Yoshio, AU - ,, Y1 - 2014/10/14/ PY - 2014/07/04/received PY - 2014/08/29/accepted PY - 2014/10/15/entrez PY - 2014/10/15/pubmed PY - 2015/12/19/medline SP - e110270 EP - e110270 JF - PloS one JO - PLoS One VL - 9 IS - 10 N2 - INTRODUCTION: Previous studies have suggested that estrogens play a role in the development of ulcerative colitis (UC). Because isoflavones have a similar structure to 17β-estradiol, dietary consumption of isoflavones may have similar influences on the development of UC. We examined the association between pre-illness isoflavone consumption and the risk of UC. MATERIALS AND METHODS: We conducted a hospital-based case control study, and compared the dietary habits of 126 newly diagnosed UC cases with those of 170 age- and gender-matched hospital controls. Information on dietary factors was collected using a self-administered diet history questionnaire. To consider potential changes in dietary habits due to disease symptoms, the habits were assessed separately during the previous 1 month and at 1 year before the recruitment. RESULTS: In the assessment of dietary habits during the previous 1 month, the highest tertile of isoflavone consumption revealed an increased odds ratio (OR) for UC (OR = 2.79; 95% confidence interval (CI), 1.39-5.59; Trend P = 0.004). A significant association was also observed for the dietary assessment at 1 year before, when most UC cases had not yet experienced their first disease symptoms (OR = 2.06; 95% CI, 1.05-4.04; Trend P = 0.04). Associations were more pronounced in females (OR in highest tertile of isoflavone consumption at 1 year before = 4.76; 95% CI, 1.30-17.5; Trend P = 0.02) but were obscured in males (corresponding OR = 1.21; 95% CI, 0.49-3.01; Trend P = 0.63). CONCLUSIONS: Dietary isoflavone consumption may be associated with an increased risk of UC, particularly in females. Prospective cohort studies are warranted to confirm these findings. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25314032/Pre_illness_isoflavone_consumption_and_disease_risk_of_ulcerative_colitis:_a_multicenter_case_control_study_in_Japan_ L2 - https://dx.plos.org/10.1371/journal.pone.0110270 DB - PRIME DP - Unbound Medicine ER -