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Associations between antioxidants and all-cause mortality among US adults with obstructive lung function.

Abstract

Chronic obstructive pulmonary disease is characterised by oxidative stress, but little is known about the associations between antioxidant status and all-cause mortality in adults with this disease. The objective of the present study was to examine the prospective associations between concentrations of α- and β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C and α-tocopherol and all-cause mortality among US adults with obstructive lung function. Data collected from 1492 adults aged 20-79 years with obstructive lung function in the National Health and Nutrition Examination Survey III (1988-94) were used. Through 2006, 629 deaths were identified during a median follow-up period of 14 years. After adjustment for demographic variables, the concentrations of the following antioxidants modelled as continuous variables were found to be inversely associated with all-cause mortality among adults with obstructive lung function: α-carotene (P= 0·037); β-carotene (P= 0·022); cryptoxanthin (P= 0·022); lutein/zeaxanthin (P= 0·004); total carotenoids (P= 0·001); vitamin C (P< 0·001). In maximally adjusted models, only the concentrations of lycopene (P= 0·013) and vitamin C (P= 0·046) were found to be significantly and inversely associated with all-cause mortality. No effect modification by sex was detected, but the association between lutein/zeaxanthin concentrations and all-cause mortality varied by smoking status (P interaction= 0·048). The concentrations of lycopene and vitamin C were inversely associated with all-cause mortality in this cohort of adults with obstructive lung function.

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  • Authors+Show Affiliations

    ,

    Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention,4770 Buford Highway, MS F78,Atlanta,GA30341,USA.

    ,

    Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention,Atlanta,GA,USA.

    ,

    Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention,4770 Buford Highway, MS F78,Atlanta,GA30341,USA.

    Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention,4770 Buford Highway, MS F78,Atlanta,GA30341,USA.

    Source

    The British journal of nutrition 112:10 2014 Nov 28 pg 1662-73

    MeSH

    Adult
    Aged
    Antioxidants
    Ascorbic Acid
    Carotenoids
    Cause of Death
    Female
    Humans
    Lung
    Male
    Middle Aged
    Oxidative Stress
    Prospective Studies
    Pulmonary Disease, Chronic Obstructive
    Smoking
    United States
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25315508

    Citation

    Ford, Earl S., et al. "Associations Between Antioxidants and All-cause Mortality Among US Adults With Obstructive Lung Function." The British Journal of Nutrition, vol. 112, no. 10, 2014, pp. 1662-73.
    Ford ES, Li C, Cunningham TJ, et al. Associations between antioxidants and all-cause mortality among US adults with obstructive lung function. Br J Nutr. 2014;112(10):1662-73.
    Ford, E. S., Li, C., Cunningham, T. J., & Croft, J. B. (2014). Associations between antioxidants and all-cause mortality among US adults with obstructive lung function. The British Journal of Nutrition, 112(10), pp. 1662-73. doi:10.1017/S0007114514002669.
    Ford ES, et al. Associations Between Antioxidants and All-cause Mortality Among US Adults With Obstructive Lung Function. Br J Nutr. 2014 Nov 28;112(10):1662-73. PubMed PMID: 25315508.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations between antioxidants and all-cause mortality among US adults with obstructive lung function. AU - Ford,Earl S, AU - Li,Chaoyang, AU - Cunningham,Timothy J, AU - Croft,Janet B, Y1 - 2014/10/15/ PY - 2014/10/16/entrez PY - 2014/10/16/pubmed PY - 2015/1/13/medline SP - 1662 EP - 73 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 112 IS - 10 N2 - Chronic obstructive pulmonary disease is characterised by oxidative stress, but little is known about the associations between antioxidant status and all-cause mortality in adults with this disease. The objective of the present study was to examine the prospective associations between concentrations of α- and β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C and α-tocopherol and all-cause mortality among US adults with obstructive lung function. Data collected from 1492 adults aged 20-79 years with obstructive lung function in the National Health and Nutrition Examination Survey III (1988-94) were used. Through 2006, 629 deaths were identified during a median follow-up period of 14 years. After adjustment for demographic variables, the concentrations of the following antioxidants modelled as continuous variables were found to be inversely associated with all-cause mortality among adults with obstructive lung function: α-carotene (P= 0·037); β-carotene (P= 0·022); cryptoxanthin (P= 0·022); lutein/zeaxanthin (P= 0·004); total carotenoids (P= 0·001); vitamin C (P< 0·001). In maximally adjusted models, only the concentrations of lycopene (P= 0·013) and vitamin C (P= 0·046) were found to be significantly and inversely associated with all-cause mortality. No effect modification by sex was detected, but the association between lutein/zeaxanthin concentrations and all-cause mortality varied by smoking status (P interaction= 0·048). The concentrations of lycopene and vitamin C were inversely associated with all-cause mortality in this cohort of adults with obstructive lung function. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25315508/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007114514002669/type/journal_article DB - PRIME DP - Unbound Medicine ER -