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Dexamethasone versus a combination of dexamethasone and ondansetron as prophylactic antiemetic in patients receiving intrathecal morphine for caesarean section.
Afr Health Sci. 2014 Jun; 14(2):453-9.AH

Abstract

BACKGROUND

Intrathecal morphine for caesarean delivery provides excellent postoperative analgesia but it is commonly associated with nausea and vomiting. This prospective, randomized, double blind study was carried out to compare the effectiveness of a combination of dexamethasone and ondansetron with dexamethasone alone for prevention of postoperative nausea and vomiting (PONV) following intrathecal morphine injection for caesarean section.

METHODS

A total of 108 parturients aged 18-40 years for elective caesarean section were randomized into 2 groups (n=54) to receive either intravenous dexamethasone 8 mg (Group A) or a combination of intravenous dexamethasone 8 mg and ondansetron 4 mg (group B). The study drug for each group consisted of 0.5% hyperbaric bupivacaine and 0.2mg morphine. The primary outcome variables were postoperative nausea and vomiting (PONV) which were assessed for a period of 24 hours. The patient's vital signs were monitored and documented.

RESULTS

The incidence of nausea and vomiting was significantly reduced in patients who received a combination of dexamethasone and ondansetron compared with dexamethasone alone (9.3% Vs 37%, respectively, P = 0.003).

CONCLUSION

This study showed that a combination of dexamethasone and ondansetron administered prophylactically significantly reduced the incidence of PONV in pregnant women on intrathecal morphine for caesarean section.

Authors+Show Affiliations

Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria; National Orthopaedic Hospital Igbobi, Lagos, Nigeria.Lagos State School of Anaesthesia, Badagry, Nigeria.Obafemi Awolowo University I le-Ife, Nigeria.Olabisi Onabanjo University Teaching Hospital, Department of Obstetrics and Gynaecology, Sagamu, Nigeria.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25320597

Citation

Imeh, Akpan, et al. "Dexamethasone Versus a Combination of Dexamethasone and Ondansetron as Prophylactic Antiemetic in Patients Receiving Intrathecal Morphine for Caesarean Section." African Health Sciences, vol. 14, no. 2, 2014, pp. 453-9.
Imeh A, Olaniyi O, Simeon O, et al. Dexamethasone versus a combination of dexamethasone and ondansetron as prophylactic antiemetic in patients receiving intrathecal morphine for caesarean section. Afr Health Sci. 2014;14(2):453-9.
Imeh, A., Olaniyi, O., Simeon, O., & Omotola, O. (2014). Dexamethasone versus a combination of dexamethasone and ondansetron as prophylactic antiemetic in patients receiving intrathecal morphine for caesarean section. African Health Sciences, 14(2), 453-9. https://doi.org/10.4314/ahs.v14i2.23
Imeh A, et al. Dexamethasone Versus a Combination of Dexamethasone and Ondansetron as Prophylactic Antiemetic in Patients Receiving Intrathecal Morphine for Caesarean Section. Afr Health Sci. 2014;14(2):453-9. PubMed PMID: 25320597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dexamethasone versus a combination of dexamethasone and ondansetron as prophylactic antiemetic in patients receiving intrathecal morphine for caesarean section. AU - Imeh,Akpan, AU - Olaniyi,Oladapo, AU - Simeon,Olateju, AU - Omotola,Odusoga, PY - 2014/10/17/entrez PY - 2014/10/17/pubmed PY - 2015/9/19/medline KW - Caesarean Section KW - Dexamethasone KW - Morphine KW - Nausea and Vomiting KW - Ondansetron SP - 453 EP - 9 JF - African health sciences JO - Afr Health Sci VL - 14 IS - 2 N2 - BACKGROUND: Intrathecal morphine for caesarean delivery provides excellent postoperative analgesia but it is commonly associated with nausea and vomiting. This prospective, randomized, double blind study was carried out to compare the effectiveness of a combination of dexamethasone and ondansetron with dexamethasone alone for prevention of postoperative nausea and vomiting (PONV) following intrathecal morphine injection for caesarean section. METHODS: A total of 108 parturients aged 18-40 years for elective caesarean section were randomized into 2 groups (n=54) to receive either intravenous dexamethasone 8 mg (Group A) or a combination of intravenous dexamethasone 8 mg and ondansetron 4 mg (group B). The study drug for each group consisted of 0.5% hyperbaric bupivacaine and 0.2mg morphine. The primary outcome variables were postoperative nausea and vomiting (PONV) which were assessed for a period of 24 hours. The patient's vital signs were monitored and documented. RESULTS: The incidence of nausea and vomiting was significantly reduced in patients who received a combination of dexamethasone and ondansetron compared with dexamethasone alone (9.3% Vs 37%, respectively, P = 0.003). CONCLUSION: This study showed that a combination of dexamethasone and ondansetron administered prophylactically significantly reduced the incidence of PONV in pregnant women on intrathecal morphine for caesarean section. SN - 1729-0503 UR - https://www.unboundmedicine.com/medline/citation/25320597/Dexamethasone_versus_a_combination_of_dexamethasone_and_ondansetron_as_prophylactic_antiemetic_in_patients_receiving_intrathecal_morphine_for_caesarean_section_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=25320597.ui DB - PRIME DP - Unbound Medicine ER -