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Worse in-hospital outcomes in patients with transient ischemic attack in association with acute kidney injury: analysis of nationwide in-patient sample.
Am J Nephrol. 2014; 40(3):258-62.AJ

Abstract

OBJECTIVES

The effect of acute kidney injury (AKI) on outcomes of transient ischemic attack (TIA) is largely unknown. We wanted to determine the impact of AKI on the outcomes of patients admitted with TIA.

METHODS

Data from all adult patients admitted to the U.S. hospitals between 2005 and 2011 with a primary discharge diagnosis of TIA and secondary diagnosis of AKI were included, using the nationwide in-patient dataset. The association of AKI with TIA-related mortality and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis.

RESULTS

Of the 1,173,340 patients admitted with TIA, 45,974 (3.8%) had AKI. Dialysis was required in 29 (0.06%) patients. TIA patients with AKI had higher rates of moderate-to-severe disability (21.2 vs. 13.7%, p ≤ 0.0001), and in-hospital mortality (0.6 vs. 0.1%, p ≤ 0.0001) compared with those without AKI. After adjusting for age, sex, and potential confounders; TIA patients with AKI had higher odds of moderate-to-severe disability [OR 1.3, 95% CI 1.2-1.4, p < 0.0001] and death (OR 4.2, 95% CI 3.0-6.1, p < 0.0001).

CONCLUSIONS

AKI in patients with TIA is associated with significantly higher rates of moderate-to-severe disability at discharge and in-hospital mortality compared with those without AKI.

Authors+Show Affiliations

Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25322955

Citation

Saeed, Fahad, et al. "Worse In-hospital Outcomes in Patients With Transient Ischemic Attack in Association With Acute Kidney Injury: Analysis of Nationwide In-patient Sample." American Journal of Nephrology, vol. 40, no. 3, 2014, pp. 258-62.
Saeed F, Adil MM, Malik AA, et al. Worse in-hospital outcomes in patients with transient ischemic attack in association with acute kidney injury: analysis of nationwide in-patient sample. Am J Nephrol. 2014;40(3):258-62.
Saeed, F., Adil, M. M., Malik, A. A., Qureshi, M. H., & Nahab, F. (2014). Worse in-hospital outcomes in patients with transient ischemic attack in association with acute kidney injury: analysis of nationwide in-patient sample. American Journal of Nephrology, 40(3), 258-62. https://doi.org/10.1159/000367855
Saeed F, et al. Worse In-hospital Outcomes in Patients With Transient Ischemic Attack in Association With Acute Kidney Injury: Analysis of Nationwide In-patient Sample. Am J Nephrol. 2014;40(3):258-62. PubMed PMID: 25322955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Worse in-hospital outcomes in patients with transient ischemic attack in association with acute kidney injury: analysis of nationwide in-patient sample. AU - Saeed,Fahad, AU - Adil,Malik M, AU - Malik,Ahmed A, AU - Qureshi,Mushtaq H, AU - Nahab,Fadi, Y1 - 2014/10/11/ PY - 2014/06/24/received PY - 2014/08/23/accepted PY - 2014/10/18/entrez PY - 2014/10/18/pubmed PY - 2015/7/21/medline SP - 258 EP - 62 JF - American journal of nephrology JO - Am J Nephrol VL - 40 IS - 3 N2 - OBJECTIVES: The effect of acute kidney injury (AKI) on outcomes of transient ischemic attack (TIA) is largely unknown. We wanted to determine the impact of AKI on the outcomes of patients admitted with TIA. METHODS: Data from all adult patients admitted to the U.S. hospitals between 2005 and 2011 with a primary discharge diagnosis of TIA and secondary diagnosis of AKI were included, using the nationwide in-patient dataset. The association of AKI with TIA-related mortality and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis. RESULTS: Of the 1,173,340 patients admitted with TIA, 45,974 (3.8%) had AKI. Dialysis was required in 29 (0.06%) patients. TIA patients with AKI had higher rates of moderate-to-severe disability (21.2 vs. 13.7%, p ≤ 0.0001), and in-hospital mortality (0.6 vs. 0.1%, p ≤ 0.0001) compared with those without AKI. After adjusting for age, sex, and potential confounders; TIA patients with AKI had higher odds of moderate-to-severe disability [OR 1.3, 95% CI 1.2-1.4, p < 0.0001] and death (OR 4.2, 95% CI 3.0-6.1, p < 0.0001). CONCLUSIONS: AKI in patients with TIA is associated with significantly higher rates of moderate-to-severe disability at discharge and in-hospital mortality compared with those without AKI. SN - 1421-9670 UR - https://www.unboundmedicine.com/medline/citation/25322955/Worse_in_hospital_outcomes_in_patients_with_transient_ischemic_attack_in_association_with_acute_kidney_injury:_analysis_of_nationwide_in_patient_sample_ L2 - https://www.karger.com?DOI=10.1159/000367855 DB - PRIME DP - Unbound Medicine ER -