Tags

Type your tag names separated by a space and hit enter

Hypopigmented mycosis fungoides versus mycosis fungoides with concomitant hypopigmented lesions: same disease or different variants of mycosis fungoides?
Dermatology. 2014; 229(3):271-4.D

Abstract

BACKGROUND

Hypopigmented mycosis fungoides (HMF) is a rare subtype of mycosis fungoides (MF). We compared patients with exclusive hypopigmented lesions with a group of MF patients with concomitant different lesions.

METHODS

20 patients with HMF only and 14 patients with hypopigmented lesions concomitant with other types of lesions (mixed MF, MMF) were selected. Clinical-epidemiological analysis as well as histological and immunohistochemical studies were performed.

RESULTS

HMF and MMF preserve some similarities, like predilection for dark-skinned persons and slow progression, but they also present differences: the exclusive variant is associated with early onset and a clear CD8+ immunophenotype, whereas MMF patients tend to present a predominance of CD4+ cell infiltrates. Histological analysis revealed similar findings; relapsing courses were common.

CONCLUSION

Whether patients are suffering from exclusive HMF or MMF, the presence of hypopigmented lesions can be considered a marker of good prognosis in MF, since both groups presented similar data, such as staging and disease duration.

Authors+Show Affiliations

Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25323446

Citation

Furlan, Fabricio C., et al. "Hypopigmented Mycosis Fungoides Versus Mycosis Fungoides With Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?" Dermatology (Basel, Switzerland), vol. 229, no. 3, 2014, pp. 271-4.
Furlan FC, Pereira BA, Sotto MN, et al. Hypopigmented mycosis fungoides versus mycosis fungoides with concomitant hypopigmented lesions: same disease or different variants of mycosis fungoides? Dermatology. 2014;229(3):271-4.
Furlan, F. C., Pereira, B. A., Sotto, M. N., & Sanches, J. A. (2014). Hypopigmented mycosis fungoides versus mycosis fungoides with concomitant hypopigmented lesions: same disease or different variants of mycosis fungoides? Dermatology (Basel, Switzerland), 229(3), 271-4. https://doi.org/10.1159/000363319
Furlan FC, et al. Hypopigmented Mycosis Fungoides Versus Mycosis Fungoides With Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides. Dermatology. 2014;229(3):271-4. PubMed PMID: 25323446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypopigmented mycosis fungoides versus mycosis fungoides with concomitant hypopigmented lesions: same disease or different variants of mycosis fungoides? AU - Furlan,Fabricio C, AU - Pereira,Bruna A, AU - Sotto,Mirian N, AU - Sanches,José Antonio, Y1 - 2014/10/11/ PY - 2014/03/04/received PY - 2014/04/30/accepted PY - 2014/10/18/entrez PY - 2014/10/18/pubmed PY - 2015/7/24/medline SP - 271 EP - 4 JF - Dermatology (Basel, Switzerland) JO - Dermatology VL - 229 IS - 3 N2 - BACKGROUND: Hypopigmented mycosis fungoides (HMF) is a rare subtype of mycosis fungoides (MF). We compared patients with exclusive hypopigmented lesions with a group of MF patients with concomitant different lesions. METHODS: 20 patients with HMF only and 14 patients with hypopigmented lesions concomitant with other types of lesions (mixed MF, MMF) were selected. Clinical-epidemiological analysis as well as histological and immunohistochemical studies were performed. RESULTS: HMF and MMF preserve some similarities, like predilection for dark-skinned persons and slow progression, but they also present differences: the exclusive variant is associated with early onset and a clear CD8+ immunophenotype, whereas MMF patients tend to present a predominance of CD4+ cell infiltrates. Histological analysis revealed similar findings; relapsing courses were common. CONCLUSION: Whether patients are suffering from exclusive HMF or MMF, the presence of hypopigmented lesions can be considered a marker of good prognosis in MF, since both groups presented similar data, such as staging and disease duration. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/25323446/Hypopigmented_mycosis_fungoides_versus_mycosis_fungoides_with_concomitant_hypopigmented_lesions:_same_disease_or_different_variants_of_mycosis_fungoides L2 - https://www.karger.com?DOI=10.1159/000363319 DB - PRIME DP - Unbound Medicine ER -