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A cluster of transverse myelitis following dengue virus infection in the brazilian Amazon region.
Trop Med Health. 2014 Sep; 42(3):115-20.TM

Abstract

BACKGROUND AND PURPOSE

During the last two decades, clinical reports have begun to place increasing emphasis on the possible neurological complications related to dengue. However, reports of cases with myelitis post dengue are rare. This study describes an unprecedented cluster of transverse myelitis following a dengue virus infection.

METHODS

51 possible cases of neurological complications related to dengue were identified by the epidemiological surveillance of the State of Rondônia, Brazil and submitted to serial neurological examination, electromyography, vertebral MR and laboratory investigation to confirm the dengue diagnosis and rule out other arboviruses.

RESULTS

The diagnosis of acute transverse myelitis post-dengue was established in 26 patients, the majority were women, young and white. Antibodies against virus IgM were present in all cases and DEN 3 virus was isolated by PCR in one patient. Treatment with IV steroids was useful.

CONCLUSIONS

The cluster of transverse myelitis post-dengue with favorable clinical outcome here reported suggests an immune mediated mechanism for the spinal cord involvement. Whereas dengue epidemics are frequent in tropical and subtropical countries, the dengue fever should be part in the differential diagnosis of the infectious and post-infectious myelitis.

Authors+Show Affiliations

Universidade Federal do Estado do Rio de Janeiro , Neurology, Mariz e Barros 775, Tijuca, Rio de Janeiro, Rio de Janeiro 20270004, BRAZIL.Universidade Federal do Estado do Rio de Janeiro , Neurology, Mariz e Barros 775, Tijuca, Rio de Janeiro, Rio de Janeiro 20270004, BRAZIL.Universidade Federal do Estado do Rio de Janeiro , Neurology, Mariz e Barros 775, Tijuca, Rio de Janeiro, Rio de Janeiro 20270004, BRAZIL.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25324689

Citation

de Sousa, Adriano Miranda, et al. "A Cluster of Transverse Myelitis Following Dengue Virus Infection in the Brazilian Amazon Region." Tropical Medicine and Health, vol. 42, no. 3, 2014, pp. 115-20.
de Sousa AM, Alvarenga MP, Alvarenga RM. A cluster of transverse myelitis following dengue virus infection in the brazilian Amazon region. Trop Med Health. 2014;42(3):115-20.
de Sousa, A. M., Alvarenga, M. P., & Alvarenga, R. M. (2014). A cluster of transverse myelitis following dengue virus infection in the brazilian Amazon region. Tropical Medicine and Health, 42(3), 115-20. https://doi.org/10.2149/tmh.2014-06
de Sousa AM, Alvarenga MP, Alvarenga RM. A Cluster of Transverse Myelitis Following Dengue Virus Infection in the Brazilian Amazon Region. Trop Med Health. 2014;42(3):115-20. PubMed PMID: 25324689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cluster of transverse myelitis following dengue virus infection in the brazilian Amazon region. AU - de Sousa,Adriano Miranda, AU - Alvarenga,Marina Papais, AU - Alvarenga,Regina Maria Papais, Y1 - 2014/06/25/ PY - 2014/03/21/received PY - 2014/05/06/accepted PY - 2014/10/18/entrez PY - 2014/10/18/pubmed PY - 2014/10/18/medline KW - Brazil KW - Dengue KW - Transverse Myelitis SP - 115 EP - 20 JF - Tropical medicine and health JO - Trop Med Health VL - 42 IS - 3 N2 - BACKGROUND AND PURPOSE: During the last two decades, clinical reports have begun to place increasing emphasis on the possible neurological complications related to dengue. However, reports of cases with myelitis post dengue are rare. This study describes an unprecedented cluster of transverse myelitis following a dengue virus infection. METHODS: 51 possible cases of neurological complications related to dengue were identified by the epidemiological surveillance of the State of Rondônia, Brazil and submitted to serial neurological examination, electromyography, vertebral MR and laboratory investigation to confirm the dengue diagnosis and rule out other arboviruses. RESULTS: The diagnosis of acute transverse myelitis post-dengue was established in 26 patients, the majority were women, young and white. Antibodies against virus IgM were present in all cases and DEN 3 virus was isolated by PCR in one patient. Treatment with IV steroids was useful. CONCLUSIONS: The cluster of transverse myelitis post-dengue with favorable clinical outcome here reported suggests an immune mediated mechanism for the spinal cord involvement. Whereas dengue epidemics are frequent in tropical and subtropical countries, the dengue fever should be part in the differential diagnosis of the infectious and post-infectious myelitis. SN - 1348-8945 UR - https://www.unboundmedicine.com/medline/citation/25324689/A_cluster_of_transverse_myelitis_following_dengue_virus_infection_in_the_brazilian_Amazon_region_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25324689/ DB - PRIME DP - Unbound Medicine ER -
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