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Fermented soybeans by Rhizopus oligosporus reduce femoral bone loss in ovariectomized rats.
Nutr Res Pract. 2014 Oct; 8(5):539-43.NR

Abstract

BACKGROUND/OBJECTIVES

Soy isoflavones are structurally similar to estrogen and bind to estrogen receptors, suggesting that they exhibit estrogenic activities; therefore, they are referred to as phytoestrogens. Fermentation may affect the bioavailability of isoflavones altering soy isoflavone glycosides in the form of aglycones. Thus, this study investigated the effects of fermented soybeans by Rhizopus oligosporus on bone metabolism in both young rats as a pilot test and in ovariectomized (ovx) old rats as a model of menopause.

MATERIALS/METHODS

In the pilot test, a total of 24 seven-week-old female Sprague-Dawley (SD) rats were fed one of three diets for a period of four weeks: casein, unfermented soybean product, or fermented soybean product by R. oligosporus. In the ovx rat model, 20-week-old SD rats weighing 260-290 g underwent either sham-operation (n = 10) or bilateral ovariectomy (n = 30) and were then fed the AIN-93M diet for one week. Thereafter, rats were fed sham-casein, ovx-casein, ovx-soybean, or ovx-fermented soybean diet for five weeks. After decapitation, femoral bones were isolated and preserved in 9% formalin for assessment of bone mineral density (BMD), bone mineral content (BMC), and bone-breaking strength (BBS).

RESULTS

Ovx rats showed significantly increased weight gain and decreased uterine wet weight. Of particular interest, ovx rats fed fermented soybeans showed increased uterine wet weights compared to control rats. Fermented soybean diet caused a significant increase in plasma 17-β estradiol concentrations in young rats, and 17-β estradiol levels were enhanced in ovx rats to match those of sham-operated ones. Significantly lower femoral BMD and BMC were observed in ovx rats compared to sham-operated controls, whereas bone areas did not differ statistically among the groups. In addition, BBS tended to be increased in ovx rats fed soybeans and fermented soybeans.

CONCLUSIONS

Supplementation of fermented soybeans could have preventive and therapeutic effects against osteoporosis in postmenopausal women.

Authors+Show Affiliations

Department of Foods & Nutrition, Kookmin University, 77 Jeongneung-ro, Seongbuk-gu, Seoul 136-702, Korea.Department of Foods & Nutrition, Kookmin University, 77 Jeongneung-ro, Seongbuk-gu, Seoul 136-702, Korea.Department of Foods & Nutrition, Kookmin University, 77 Jeongneung-ro, Seongbuk-gu, Seoul 136-702, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25324934

Citation

Yoo, Hyun-Wook, et al. "Fermented Soybeans By Rhizopus Oligosporus Reduce Femoral Bone Loss in Ovariectomized Rats." Nutrition Research and Practice, vol. 8, no. 5, 2014, pp. 539-43.
Yoo HW, Chang MJ, Kim SH. Fermented soybeans by Rhizopus oligosporus reduce femoral bone loss in ovariectomized rats. Nutr Res Pract. 2014;8(5):539-43.
Yoo, H. W., Chang, M. J., & Kim, S. H. (2014). Fermented soybeans by Rhizopus oligosporus reduce femoral bone loss in ovariectomized rats. Nutrition Research and Practice, 8(5), 539-43. https://doi.org/10.4162/nrp.2014.8.5.539
Yoo HW, Chang MJ, Kim SH. Fermented Soybeans By Rhizopus Oligosporus Reduce Femoral Bone Loss in Ovariectomized Rats. Nutr Res Pract. 2014;8(5):539-43. PubMed PMID: 25324934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fermented soybeans by Rhizopus oligosporus reduce femoral bone loss in ovariectomized rats. AU - Yoo,Hyun-Wook, AU - Chang,Moon-Jeong, AU - Kim,Sun-Hee, Y1 - 2014/05/15/ PY - 2014/01/16/received PY - 2014/02/18/revised PY - 2014/02/19/accepted PY - 2014/10/18/entrez PY - 2014/10/18/pubmed PY - 2014/10/18/medline KW - 17-β estradiol KW - Fermented soybean KW - bone mineral density (BMD) KW - bone-breaking strength SP - 539 EP - 43 JF - Nutrition research and practice JO - Nutr Res Pract VL - 8 IS - 5 N2 - BACKGROUND/OBJECTIVES: Soy isoflavones are structurally similar to estrogen and bind to estrogen receptors, suggesting that they exhibit estrogenic activities; therefore, they are referred to as phytoestrogens. Fermentation may affect the bioavailability of isoflavones altering soy isoflavone glycosides in the form of aglycones. Thus, this study investigated the effects of fermented soybeans by Rhizopus oligosporus on bone metabolism in both young rats as a pilot test and in ovariectomized (ovx) old rats as a model of menopause. MATERIALS/METHODS: In the pilot test, a total of 24 seven-week-old female Sprague-Dawley (SD) rats were fed one of three diets for a period of four weeks: casein, unfermented soybean product, or fermented soybean product by R. oligosporus. In the ovx rat model, 20-week-old SD rats weighing 260-290 g underwent either sham-operation (n = 10) or bilateral ovariectomy (n = 30) and were then fed the AIN-93M diet for one week. Thereafter, rats were fed sham-casein, ovx-casein, ovx-soybean, or ovx-fermented soybean diet for five weeks. After decapitation, femoral bones were isolated and preserved in 9% formalin for assessment of bone mineral density (BMD), bone mineral content (BMC), and bone-breaking strength (BBS). RESULTS: Ovx rats showed significantly increased weight gain and decreased uterine wet weight. Of particular interest, ovx rats fed fermented soybeans showed increased uterine wet weights compared to control rats. Fermented soybean diet caused a significant increase in plasma 17-β estradiol concentrations in young rats, and 17-β estradiol levels were enhanced in ovx rats to match those of sham-operated ones. Significantly lower femoral BMD and BMC were observed in ovx rats compared to sham-operated controls, whereas bone areas did not differ statistically among the groups. In addition, BBS tended to be increased in ovx rats fed soybeans and fermented soybeans. CONCLUSIONS: Supplementation of fermented soybeans could have preventive and therapeutic effects against osteoporosis in postmenopausal women. SN - 1976-1457 UR - https://www.unboundmedicine.com/medline/citation/25324934/Fermented_soybeans_by_Rhizopus_oligosporus_reduce_femoral_bone_loss_in_ovariectomized_rats_ L2 - https://e-nrp.org/DOIx.php?id=10.4162/nrp.2014.8.5.539 DB - PRIME DP - Unbound Medicine ER -
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